Self-folded microrobot for active drug delivery and rapid ultrasound-triggered drug release

Darmawan, Bobby Aditya; Lee, Sang Bong; Nguyen, Van Du; Go, Gwangjun; Nguyen, Kim Tien; Lee, Han Sol; Nan, Minghui; Hong, Ayoung; Kim, Chang‐Sei; Li, Hao; Bang, Doyeon; Park, Jong-Oh; Choi, Eunpyo

doi:10.1016/j.snb.2020.128752

Cited by 59 publications

(59 citation statements)

References 39 publications

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“…261,262 Programmable actuation behaviours can be useful for overcoming the various challenges and limitations of biomedical devices; for instance, actuation may enable a fine control of biological events by adding a fourth dimension to the biological system (i.e., the temporal coordinate). The overall goal of bioactuators is to generate functional outcomes in the form of responses to various external physical or chemical stimuli, including temperature, [263][264][265] pH, [266][267][268][269] ionic strength, [270][271][272] oxidation/reduction, [273][274][275] light, [276][277][278][279][280] and electric [281][282][283][284] or magnetic fields [285][286][287] that satisfy biocompatible conditions.…”

Section: Actuatorsmentioning

confidence: 99%

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

et al. 2021

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Section: Actuatorsmentioning

confidence: 99%

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

et al. 2021

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“…Robots ranging from 3 mm down to 300 µm were acoustically levitated within the workspace and controlled by an ambient magnetic field. In 2020, Darmawan et al demonstrated magnetically controlled helical small-scale robots that release onboard drugs under ultrasound stimulation [92]. Thus, there exists an exciting opportunity to utilize US for not only imaging but also actuation in next-generation small-scale robotic systems.…”

Section: Small-scale Magnetic Robot Workpace Referencementioning

confidence: 99%

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Zhang

2021

Micromachines

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Small-scale magnetic robots are remotely actuated and controlled by an externally applied magnetic field. These robots have a characteristic size ranging from several millimetres down to a few nanometres. They are often untethered in order to access constrained and hard-to-reach space buried deep in human body. Thus, they promise to bring revolutionary improvement to minimally invasive diagnostics and therapeutics. However, existing research is still mostly limited to scenarios in over-simplified laboratory environment with unrealistic working conditions. Further advancement of this field demands researchers to consider complex unstructured biological workspace. In order to deliver its promised potentials, next-generation small-scale magnetic robotic systems need to address the constraints and meet the demands of real-world clinical tasks. In particular, integrating medical imaging modalities into the robotic systems is a critical step in their evolution from laboratory toys towards potential life-savers. This review discusses the recent efforts made in this direction to push small-scale magnetic robots towards genuine biomedical applications. This review examines the accomplishment achieved so far and sheds light on the open challenges. It is hoped that this review can offer a perspective on how next-generation robotic systems can not only effectively integrate medical imaging methods, but also take full advantage of the imaging equipments to enable additional functionalities.

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“…Various types of agents containing magnetic materials have been developed over the years; nanodroplets 25 , paramagnetic hollow silica nanospheres 26 , hollow silica NPs doped with iron 27 , 28 , lipid-shelled MBs with attached iron oxide NPs functionalized with heparin 29 , lipospheres with genes or nucleic acids 30 , 31 US-driven nanomotors 32 , and magnetically responsive nanorobots 33 , 34 . Amongst them, also SPIONs are desirable candidates for a theranostic mediator for controlled delivery and release as they possess the ability to function at the cellular and molecular level.…”

Section: Controlled Drug Delivery and Releasementioning

confidence: 99%

Magnetic mediators for ultrasound theranostics

Józefczak¹,

Kaczmarek²,

Bielas³

2021

Theranostics

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Self-folded microrobot for active drug delivery and rapid ultrasound-triggered drug release

Cited by 59 publications

References 39 publications

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

Engineering bioactive synthetic polymers for biomedical applications: a review with emphasis on tissue engineering and controlled release

Evolving from Laboratory Toys towards Life-Savers: Small-Scale Magnetic Robotic Systems with Medical Imaging Modalities

Magnetic mediators for ultrasound theranostics

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