Self-gated porous organic polymer as drug delivery system for pH stimuli-responsive controlled Quercetin release

Xu, Zhilu; Hu, Lianxi; Ming, Jingjing; Cui, Xiaoming; Zhang, Meng; Dou, Jinli; Zhang, Weifen; Zhou, Baolong

doi:10.1016/j.micromeso.2020.110259

Cited by 57 publications

(30 citation statements)

References 22 publications

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“…Therefore, the mass ratio of 1 : 5 was used for the subsequent experiments. [30] The release behavior of NAT was estimated via the in vitro release experiment. [31] It can be seen from Figure 4, the rapid release occurred in the initial few hours is mainly attributed to the NAT adsorbed on the surface of ICOP.…”

Section: Resultsmentioning

confidence: 99%

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Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

et al. 2021

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Here, we have strategically prepared a biodegradable ionic covalent organic porous polymers (ICOP) with dynamic double selenium bond (SeÀ Se) which was further used as carriers for the antifungal drug-natamycin (NAT). ICOP presents a high drug-loading capability (DL) of 79.33 � 0.12 %, as well as high encapsulation efficiency (EE) of 76.75 � 0.58 % to NAT. Meanwhile, owning to the simultaneous introduction of À SeÀ SeÀ bond and imine linkage, the composite drug delivery system are responsive to pH, with selective and sustained release in acidic media (pH = 5.5), almost 1.34 fold as much as that in neutral conditions (pH = 7.4). This special drug release behavior is consisted well with the optimum growing environment of candida albicans (pH = 5.5), in which, more drugs could be released continuously, enhancing the duration of drug interactions with fungi and inhibiting the growth of fungus effectively. This novel dosing strategy is promising for the development of intelligent drug delivery system which could avoid the overdoses of drugs, and reduce the emergence of resistant strains.

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Section: Resultsmentioning

confidence: 99%

“…Afterwards, the LC and EE value decreased as the increase of the quality of NAT. Therefore, the mass ratio of 1 : 5 was used for the subsequent experiments [30] …”

Section: Resultsmentioning

confidence: 99%

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

et al. 2021

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“…The POP was formed via condensation between absorbable D-Mannitol (MA) and biodegradable hexa(p-formylphenyl)cyclotriphosphazene (HCTP). Que loading was performed by a simple physical adsorption mechanism followed by firm retention in the porous skeletons via both hydrogen bonding and van der Waals' force (Xu et al, 2020). Their data showed that the acetal linkages resulted from the condensation of MA and HCTP in Que-POP served as the gatekeeper that was stable with almost no release of Que in neutral conditions, whereas in the acidic tumor microenvironment (pH = 5.4), controlled-release of Que was observed owing to pH-triggered disintegration of the POP (Xu et al, 2020).…”

Section: 11mentioning

confidence: 99%

“…Que loading was performed by a simple physical adsorption mechanism followed by firm retention in the porous skeletons via both hydrogen bonding and van der Waals' force (Xu et al, 2020). Their data showed that the acetal linkages resulted from the condensation of MA and HCTP in Que-POP served as the gatekeeper that was stable with almost no release of Que in neutral conditions, whereas in the acidic tumor microenvironment (pH = 5.4), controlled-release of Que was observed owing to pH-triggered disintegration of the POP (Xu et al, 2020). Another study made use of electrostatic cross-linking to synthesize casein-amorphous calcium phosphate nanoparticles for encapsulation of Cur with (casein-ACP-(NaPO 3 ) 6 ) or without the use of hexametaphosphate ((NaPO 3 ) 6 ) (casein-ACP) as a dispersant (Niu et al, 2020).…”

Section: 11mentioning

confidence: 99%

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

Shishir

Gowd

Suo

et al. 2021

Comp Rev Food Sci Food Safe

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Many important food bioactive compounds are plant secondary metabolites that have traditional applications for health promotion and disease prevention. However, the chemical instability and poor bioavailability of these compounds represent major challenges to researchers. In the last decade, therefore, major impetus has been given for the research and development of advanced carrier systems for the delivery of natural bioactive molecules. Among them, stimuli-responsive carriers hold great promise for simultaneously improving stability, bioavailability, and more importantly delivery and on-demand release of intact bioactive phytochemicals to target sites in response to certain stimuli or combination of them (e.g., pH, temperature, oxidant, enzyme, and irradiation) that would eventually enhance therapeutic outcomes and reduce side effects. Hybrid formulations (e.g., inorganic-organic complexes) and multi-stimuli-responsive formulations have demonstrated great potential for future studies. Therefore, this review systematically compiles and assesses the recent advances on the smart delivery of food bioactive compounds, particularly quercetin, curcumin, and resveratrol through stimuli-responsive carriers, and critically reviews their functionality, underlying triggered-release mechanism, and therapeutic potential. Finally, major limitations, contemporary challenges, and possible solutions/future research directions are highlighted. Much more research is needed to optimize the processing parameters of existing formulations and to develop novel ones for lead food bioactive compounds to facilitate their food and nutraceutical applications.

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“…In addition, the diversity of polymer synthesis routes also contributes to the design and construction of porous polymers with pore skeletons or functional groups on the pore surface. [ 19,20 ] So far porous polymerics have been substantially explored in gas storage, [ 21,22 ] drug release, [ 23,24 ] catalyst carriers, [ 25 ] sensors, [ 26 ] and dielectric materials. [ 27,28 ] A variety of methods have been established for constructing porous polymer materials, such as interfacial polymerization and HIPE template method.…”

Section: Introductionmentioning

confidence: 99%

Biomass‐Derived Acetylenic Polymer Monoliths Prepared by High Internal Phase Emulsion Template Method and Used for Adsorbing Cationic Pollutants

Yang

Yong

Zhao

et al. 2021

Macro Chemistry & Physics

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A new type of biobased porous polymer monolith is prepared starting from biomass, ferulic acid (FA), via high internal phase emulsion (HIPE) template polymerization method. FA is transferred into an acetylenic monomer, which undergoes catalytic HIPE polymerization, eventually forming a porous monolith named as PolyHIPE. The phenolic hydroxyl groups in the monolith are functionalized with sodium hydroxide, forming PolyHIPE‐Na+ and meanwhile transforming the initial hydrophobic monolith into a hydrophilic one. The formation and structure of the monoliths are characterized with Fourier transform infrared (FT‐IR), NMR, and scanning electron microscope (SEM) techniques. The adsorption capacity of the monoliths is further investigated. PolyHIPE‐Na+ exhibits high adsorption capacity toward methylene blue (MB) and cetyltrimethylammonium bromide (CTAB) from simulated wastewater. The adsorption behavior of PolyHIPE‐Na+ is found to fit the pseudo second order kinetic model better. The adsorption isotherm can be well described by the Langmuir isotherm model. The maximum adsorption capacity for MB and CTAB are 1016 and 1390 mg g−1, respectively. The biobased FA derived monolithic adsorbent also shows desirable recycling usability and stability in adsorption−desorption cycles.

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Self-gated porous organic polymer as drug delivery system for pH stimuli-responsive controlled Quercetin release

Cited by 57 publications

References 22 publications

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

Guanidinium‐Based Ionic Covalent Organic Porous Polymer as Natamycin Delivery Agents for Anti‐Candida albicans

Advances in smart delivery of food bioactive compounds using stimuli‐responsive carriers: Responsive mechanism, contemporary challenges, and prospects

Biomass‐Derived Acetylenic Polymer Monoliths Prepared by High Internal Phase Emulsion Template Method and Used for Adsorbing Cationic Pollutants

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