Self-Injurious Behavior in Acquired Sensory Neuropathy

Es, Roach; Js, Abramson; Mr, Lawless

doi:10.1055/s-2008-1059532

Cited by 11 publications

(10 citation statements)

References 3 publications

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“…SIB and altered pain experiences are also associated with a wide spectrum of neurological (acquired sensory neuropathies; Roach, et al 1985), psychiatric (borderline personality disorder, Herpertz, 1995), and developmental (autism, Bodfish et al 2000) disorders. In autism and related pervasive developmental disorders, for example, it has long been recognized that many individuals have reduced sensation or responses to presumably painful stimuli (Ornitz, 1976).…”

Section: Discussionmentioning

confidence: 99%

Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Symons

2011

Neuroscience & Biobehavioral Reviews

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Self-injurious behavior (SIB) among individuals with intellectual and related neurodevelopmental disorders (IDD) is a clinical challenge and scientific puzzle. The physiological mechanisms regulating the sensory components of SIB remain a mystery with no clear understanding of the underlying pathophysiology. The central dogma regarding sensory processing in general and pain in particular among individuals with IDD and chronic SIB is that sensory processing is reduced and pain is absent or blunted. In this paper, recent findings challenging some of the conventional wisdom regarding pain and sensory function among individuals with IDD and SIB are reviewed. It seems that at least a subgroup of individuals with IDD and chronic SIB may be in a physiological state similar to neuropathic pain in which hyperalgesia is mediated by plasticity mechanisms regulating inflammatory, immune, and nociceptive systems. In response to repeated tissue damage associated with chronic self-injury, innate immune cells may be producing pro-inflammatory and pro-nociceptive cytokines that act on the brain to cause sickness-like behavior and sensitize primary sensory nerve afferents contributing to pain hypersensitivity (i.e., hyperalgesia).

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Section: Discussionmentioning

confidence: 99%

Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Symons

2011

Neuroscience & Biobehavioral Reviews

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“…However, the small sensory nerves involved in organophosphate neuropathy can also give rise to normal results, thus by no means excluding its presence. 9 …”

Section: Discussionmentioning

confidence: 99%

Delayed Effects of Transcutaneous Organophosphate Poisoning in Four Children

Pavlović

Neubauer

Al-Tawari

2015

Child Neurology Open

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Contamination or transcutaneous absorption of organophosphates (OP) is rare and there exist only few reports of such manner of poisoning. We report four children from the same family in whom temporal proximity of the disease onset, a detailed interrogation of parents and exclusion of other clinical differentials, led to the diagnosis of transcutaneous intoxication with organophosphates (diazinon). The contamination occurred during the game with a freshly used poison can. Uncommon clinical picture was marked by delayed signs predominantly reflecting certain nicotinic effects (muscle weakness, cramps) along with subtle neuropathic features occurring throughout a few weeks after initial event. Our illustrative cases can further contribute to the better awareness and understanding of variable spectrum of transcutaneous route of OP poisoning.

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“…SM was rarely seen in patients with acquired neuropathy or spinal cord injury. Roach et al (13) have described two such patients. One child mutilated the fingers distal to a traumatic median nerve injury, while the other injured himself during the course of neuropathy due to insecticide poisoning (13).…”

Section: Introductionmentioning

confidence: 98%

“…Roach et al (13) have described two such patients. One child mutilated the fingers distal to a traumatic median nerve injury, while the other injured himself during the course of neuropathy due to insecticide poisoning (13). Interestingly, Swoboda et al (14) have reported on a familial form of carpal tunnel syndrome manifested in a infant with SM of the digits innervated by the entrapped median nerve.…”

Section: Introductionmentioning

confidence: 98%

Hereditary neuropathies with self-mutilation

Gadoth

Mass

2015

J Pediatr Neurol

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Although self-mutilation (SM) is not rare in the general population, the most common causes for this mode of destructive behavior are mental retardation and psychiatric ailments. There are 2 types of neuropathies with mutilation, those with spontaneous mutilation of tissues and the others in which the patients mutilate themselves. A number of hereditary disorders are associated with SM. Among the eight MIM (Mendelian Inheritance in Man) entries associated with SM, there are four conditions, which are associated with peripheral neuropathy (choreo-acanthocytosis,.acanthocytosis with neurological impairment, congenital insensitivity to pain with anhydrosis and the paroxysmal neuropathy of type I tyrosinemia). The other four (Tourette syndrome, Lesch-Nyhan syndrome, Lesch-Nyhan phenotype with normal hypoxanthine guanine phosphoribosyle transferase and Cri-du-chat syndrome) are not associated with peripheral neuropathy. It is quite surprising that in the latest editions of the classical textbooks of pediatrics, pediatric neurology and adult neurology SM is mentioned only with regard to Lesch-Nyhan syndrome. In this paper, we describe our experience with a number of hereditary mutilating neuropathies and review some of the recent advances in the neurobiology of SM. The recognition and awareness of this outstanding clinical sign may be helpful in reaching a correct diagnosis and offering symptomatic treatment, to avoid potential tissue damage at an earlier stage of the disease. (J Pediatr Neurol 2004; 2(4): 205?211).

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Self-Injurious Behavior in Acquired Sensory Neuropathy

Cited by 11 publications

References 3 publications

Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Self-injurious behavior in neurodevelopmental disorders: Relevance of nociceptive and immune mechanisms

Delayed Effects of Transcutaneous Organophosphate Poisoning in Four Children

Hereditary neuropathies with self-mutilation

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