2020
DOI: 10.1021/acsnano.0c07696
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Self-Limiting Polymerization of DNA Origami Subunits with Strain Accumulation

Abstract: Biology demonstrates how a near infinite array of complex systems and structures at many scales can originate from the self-assembly of component parts on the nanoscale. But to fully exploit the 2 benefits of self-assembly for nanotechnology, a crucial challenge remains: How do we rationally encode well-defined global architectures in subunits that are much smaller than their assemblies? Strain accumulation via geometric frustration is one mechanism that has been used to explain the self-assembly of global arc… Show more

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Cited by 37 publications
(36 citation statements)
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“…Another significant application area for oxDNA has been the simulation of large structures to assess their conformation, stability and flexibility ( Fernandez-Castanon et al, 2016 ; Schreck et al, 2016 ; Sharma et al, 2017 ; Shi et al, 2017 ; Benson et al, 2018 ; Choi et al, 2018 ; Coronel et al, 2018 ; Berengut et al, 2019 ; Brady et al, 2019 ; Hoffecker et al, 2019 ; Snodin et al, 2019 ; Berengut et al, 2020 ; Chhabra et al, 2020 ; Poppleton et al, 2020 ; Tortora et al, 2020 ; Yao et al, 2020 ).…”
Section: Dynamical Simulationsmentioning
confidence: 99%
“…Another significant application area for oxDNA has been the simulation of large structures to assess their conformation, stability and flexibility ( Fernandez-Castanon et al, 2016 ; Schreck et al, 2016 ; Sharma et al, 2017 ; Shi et al, 2017 ; Benson et al, 2018 ; Choi et al, 2018 ; Coronel et al, 2018 ; Berengut et al, 2019 ; Brady et al, 2019 ; Hoffecker et al, 2019 ; Snodin et al, 2019 ; Berengut et al, 2020 ; Chhabra et al, 2020 ; Poppleton et al, 2020 ; Tortora et al, 2020 ; Yao et al, 2020 ).…”
Section: Dynamical Simulationsmentioning
confidence: 99%
“…Complementary DNA strands hybridise via Watson and Crick base pairing between A-T or G-C bases to form the DNA double helix or duplex (1), whose structural (2) and physical (3)(4)(5) properties are well characterised. In addition to its essential role in biology, DNA hybridisation also underpins DNA nanotechnology (6)(7)(8), which utilises DNA self-assembly for the construction of rationally designed nanoscale structures and machines (9)(10)(11)(12)(13)(14)(15)(16). DNA nanotechnology has led to the development of a broad range of technologies including applications in molecular sensing (17)(18)(19)(20), coordinating complex reaction cascades (21)(22)(23), drug delivery vessels (24)(25)(26)(27) and super resolution imaging methods, such as DNA points accumulation for imaging in nanoscale topography (DNA-PAINT) (28).…”
Section: Introductionmentioning
confidence: 99%
“…47 Moreover, the latest version of the model is able to accurately model the structural properties of DNA origami, 20 and so has been applied to study a wide range of different types of DNA origami. 21–23,38,61 Given the above, we are confident in using oxDNA to calculate the free-energy landscapes for our chosen DNA origamis, as detailed in the rest of this article.…”
Section: Introductionmentioning
confidence: 99%
“…Additionally, for origamis that are designed to assemble into higher-order structures, the monomer landscapes could help predict the thermodynamics of stress accumulation, particularly for examples where the stress accumulation is a design feature, for example, to make the assembly self-limiting. 38,39…”
Section: Introductionmentioning
confidence: 99%