Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Rehman, Mubashar; Khan, Muhammad Ziaullah; Tayyab, Muhammad; Madni, Asadullah; Khalid, Qandeel

doi:10.3791/63995

Cited by 2 publications

(2 citation statements)

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“…They behave like isotropic mixtures of lipids, drugs, and surfactants. Upon dilution in biological fluids, they form clear o/w emulsions with the help of the agitated movement of the stomach and intestinal motility [44].…”

Section: Self-nanoemulsification Methodsmentioning

confidence: 99%

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Ashfaq,

Rasul,

Asghar

et al. 2023

IJMS

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Nano-range bioactive colloidal carrier systems are envisaged to overcome the challenges associated with treatments of numerous diseases. Lipid nanoparticles (LNPs), one of the extensively investigated drug delivery systems, not only improve pharmacokinetic parameters, transportation, and chemical stability of encapsulated compounds but also provide efficient targeting and reduce the risk of toxicity. Over the last decades, nature-derived polyphenols, vitamins, antioxidants, dietary supplements, and herbs have received more attention due to their remarkable biological and pharmacological health and medical benefits. However, their poor aqueous solubility, compromised stability, insufficient absorption, and accelerated elimination impede research in the nutraceutical sector. Owing to the possibilities offered by various LNPs, their ability to accommodate both hydrophilic and hydrophobic molecules and the availability of various preparation methods suitable for sensitive molecules, loading natural fragile molecules into LNPs offers a promising solution. The primary objective of this work is to explore the synergy between nature and nanotechnology, encompassing a wide range of research aimed at encapsulating natural therapeutic molecules within LNPs.

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Section: Self-nanoemulsification Methodsmentioning

confidence: 99%

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Ashfaq,

Rasul,

Asghar

et al. 2023

IJMS

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“…Initially, SNEDDS were tested by centrifugation for 45 min at 13,500 rpm, using a centrifuge machine. Afterward, the SNEDDS were exposed to harsh temperature conditions, i.e., freezing (−20 • C) and heating (50 • C) through incubation at 4 • C, followed by storage at 25 • C for observation of any visible signs of instability [19].…”

Section: Size Poly Dispersity Index (Pdi) Zeta Potential and Sem Anal...mentioning

confidence: 99%

Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential

Arshad

Tabish

et al. 2022

Pharmaceutics

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The enteric system residing notorious Salmonella typhimurium (S. typhi) is an intracellular, food-borne, and zoonotic pathogen causing typhoid fever. Typhoid fever is one of the leading causes of mortality and morbidity in developing and underdeveloped countries. It also increased the prevalence of multidrug resistance globally. Currently, available anti-bacterial modalities are unable to penetrate into the intracellular compartments effectively for eradicating S. typhi infection. Therefore, in this study, we developed nanostructured lipid-based carriers in the form of a self-nanoemulsifying drug delivery system (SNEDDS) for targeted delivery of ciprofloxacin (CIP) into the S. typhi intracellular reservoirs. Capryol 90, Tween 80, and Span 20 were finalized as suitable oil, surfactant, and co-surfactant, respectively, according to the pseudoternary phase diagram emulsifying region. Targeting capability and mucopenetration of the SNEDDS was attributed to the inclusion of amidated pluronic (NH2-F127). Developed NH2-F127 SNEDDS were characterized via physicochemical, in vitro, ex vivo, and in vivo evaluation parameters. The size of the SNEDDS was found to be 250 nm, having positively charged zeta potential. In vitro dissolution of SNEDDS showed 80% sustained release of CIP in 72 h with maximum entrapment efficiency up to 90% as well as good hemocompatibility by showing less than 0.2% hemolysis and 90% biocompatibility. The survival rate of S. typhi in macrophages (RAW 264.7) was minimal, i.e., only 2% in the case of NH2-F127 SNEDDS. Macrophage uptake assay via nanostructures confirmed the maximum cellular uptake as evidenced by the highest fluorescence. Biofilm dispersion assay showed rapid eradication of developed resistant biofilms on the gall bladder. In vivo pharmacokinetics showed improved bioavailability by showing an increased area under the curve (AUC) value. Taken together, NH2-F127-SNEDDS can be utilized as an alternative and efficient delivery system for the sustained release of therapeutic amounts of CIP for the treatment of S. typhi.

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Cited by 2 publications

References 0 publications

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Lipid Nanoparticles: An Effective Tool to Improve the Bioavailability of Nutraceuticals

Amidated Pluronic Decorated Muco-Penetrating Self-Nano Emulsifying Drug Delivery System (SNEDDS) for Improved Anti-Salmonella typhi Potential

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