Self-nanoemulsifying drug delivery system for pancreatic cancer

Parveen, Neha; Sheikh, Afsana; Abourehab, Mohammed A.S.; Karwasra, Ritu; Singh, Surender; Kesharwani, Prashant

doi:10.1016/j.eurpolymj.2023.111993

Cited by 25 publications

(3 citation statements)

References 103 publications

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“…[ 215,216 ] Imprinted polydopamine (PDA) is a simple and versatile method. [ 217,218 ] Turan, [ 219 ] proposed SERS combined with a molecularly imprinted polymer method, and a new method for detecting PSA in serum, which forms a plasma structure between MIP and SERS. Figure b presents the manufacturing principle of plasma sensors that can effectively detect prostate‐cancer markers in clinical practice.…”

Section: Clinical Applications Of Raman Spectroscopymentioning

confidence: 99%

Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges

Wang,

Fang,

Wang

et al. 2023

Advanced Science

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Early clinical diagnosis, effective intraoperative guidance, and an accurate prognosis can lead to timely and effective medical treatment. The current conventional clinical methods have several limitations. Therefore, there is a need to develop faster and more reliable clinical detection, treatment, and monitoring methods to enhance their clinical applications. Raman spectroscopy is noninvasive and provides highly specific information about the molecular structure and biochemical composition of analytes in a rapid and accurate manner. It has a wide range of applications in biomedicine, materials, and clinical settings. This review primarily focuses on the application of Raman spectroscopy in clinical medicine. The advantages and limitations of Raman spectroscopy over traditional clinical methods are discussed. In addition, the advantages of combining Raman spectroscopy with machine learning, nanoparticles, and probes are demonstrated, thereby extending its applicability to different clinical phases. Examples of the clinical applications of Raman spectroscopy over the last 3 years are also integrated. Finally, various prospective approaches based on Raman spectroscopy in clinical studies are surveyed, and current challenges are discussed.

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Section: Clinical Applications Of Raman Spectroscopymentioning

confidence: 99%

Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges

Wang,

Fang,

Wang

et al. 2023

Advanced Science

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“…SNEDDSs are used to improve the solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs [41]. The selection of surfactant, oil, and co-surfactant components can impact the physical properties and performance of the resulting nano-emulsion, such as particle size, stability, and drug release profile [42].…”

Section: Screening Of Components For Sa-sne Developmentmentioning

confidence: 99%

Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2

Alhadrami,

El-Din,

Hassan

et al. 2023

Pharmaceutics

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This study aimed to develop a self-nanoemulsifying drug delivery system (SNE) for sinapic acid (SA) to improve its solubility and antiviral activity. Optimal components for the SA-SNE formulation were selected, including Labrafil as the oil, Cremophor EL as the surfactant, and Transcutol as the co-surfactant. The formulation was optimized using surface response design, and the optimized SA-SNE formulation exhibited a small globule size of 83.6 nm, high solubility up to 127.1 ± 3.3, and a 100% transmittance. In vitro release studies demonstrated rapid and high SA release from the formulation. Pharmacokinetic analysis showed improved bioavailability by 2.43 times, and the optimized SA-SNE formulation exhibited potent antiviral activity against SARS-CoV-2. The developed SA-SNE formulation can enhance SA’s therapeutic efficacy by improving its solubility, bioavailability, and antiviral activity. Further in silico, modeling, and Gaussian accelerated molecular dynamics (GaMD)-based studies revealed that SA could interact with and inhibit the viral main protease (Mpro). This research contributes to developing effective drug delivery systems for poorly soluble drugs like SA, opening new possibilities for their application via nebulization in SARS-CoV-2 therapy.

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“…One is pancreatic ductal adenocarcinoma (PDAC), the most common subtype of exocrine pancreatic cancer which typically arises in the cells lining the pancreatic ducts and is often diagnosed at an advanced stage. 8 The other subtype is adenosquamous carcinoma which contains both exocrine glandular tissue and squamous epithelial tissue. It is relatively rare and tends to be more aggressive.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

Kumar Shukla,

Parihar,

Karthikeyan

et al. 2023

Nanoscale

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Self-nanoemulsifying drug delivery system for pancreatic cancer

Cited by 25 publications

References 103 publications

Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges

Current Trends of Raman Spectroscopy in Clinic Settings: Opportunities and Challenges

Development and Evaluation of a Self-Nanoemulsifying Drug Delivery System for Sinapic Acid with Improved Antiviral Efficacy against SARS-CoV-2

Multifunctional GQDs for receptor targeting, drug delivery, and bioimaging in pancreatic cancer

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