In this paper the system performance of an MC-CDMA (multi-carrier coded-division multiple-access) system operating over single-cell with two-tier femtocell environment is analyzed. Consider two-tier scenario is deployed with a macrocell site in which is being surrounded several femtocells, which are designed to serve a group of subscribers locate in a small coverage area such as small office, home office or a house. The coverage area is typically up to 100 meters in radius. Mostly, the femtocell is applied to serve indoor subscribers, thus, the Rayleigh fading is adopted to characterize the propagation channel. The technique of TH-MC-CDMA (time-hopped multi-carrier coded-division multiple-access) technique is supposed to transmit each symbol alternatively with fair time (slotting)/frequency (coding) for each user in the hotspots (the area around 0 th femtocell). The intensity of signals estimated at a mobile unit located in the second tie, i.e., the femtocell coverage area, is an important issue. The contribution of the paper is mainly to evaluate the system performance with both the BER (bit error rate) and OP (outage probability) according to the most important parameters, for example, the activating user number, the hopping number provided by TH-MC-CDMA system and the subcarrier number. Furthermore, the discussion of interference avoidance is also discussed with non-analytically.