Several decades of development in the fields of robotics and automation has resulted in human-robot-interaction being commonplace, and the subject of intense study. These interactions are particularly prevalent in manufacturing, where human operators have been employed in a number of robotics and automation tasks. The presence of human operators continues to be a source of uncertainty in such systems, despite the study of human factors, in an attempt to better understand these variations in performance. Concurrent developments in intelligent manufacturing present opportunities for adaptability within robotic control. This work examines relevant human factors and develops a framework for integrating the necessary elements of intelligent control and data processing to provide appropriate adaptability to robotic elements, consequently improving collaborative interaction with human colleagues. A neural network-based learning approach is used to predict the influence on human task performance and use these predictions to make informed changes to programmed behaviour, and a methodology developed to further explore the application of learning techniques to this area. The work is supported by an example case-study, in which a simulation model is used to explore the application of the developed system, and its performance in a real-world production scenario. The simulation results reveal that adaptability can be realised with some relatively simple techniques and models if applied in the right manner and that such adaptability is helpful to tackle the issue of performance disparity in manufacturing operations. NTP: This paper presents research into the application of intelligent methodologies to this problem and builds a framework to describe how this information can be captured, generated and used, within manufacturing production processes. This framework helps identify which areas require further research and serves as a basis for the development of a methodology, by which a control system may enable adaptable behaviour to reduce the impact of human performance variation and improve human-machine-interaction. The paper also presents a simulation-based case study, to support the development and evaluate the presented control system on a representative real-world problem. The methodology makes use of a machine learning approach to identify the complex influence of a number of identified human factors on human performance. This knowledge can be used to adjust the robotic behaviour to match the predicted performance of a number of different operators over a number of scenarios. The adaptability reduces performance disparity, reducing idle times and enabling leaner production through WIP reduction. Future work