Self-organized pullulan/deoxycholic acid nanogels: Physicochemical characterization and anti-cancer drug-releasing behavior

Na, Kun; Park, Kyong Mi; Jo, Eun Ae; Lee, Kwan Shik

doi:10.1007/bf02932041

Cited by 26 publications

(7 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It has been reported that pullulan can be self‐assembled as nanoparticles after partly modified by hydrophobic molecules, such as cholesterol 26, 27. Many researchers entrapped protein, anticancer drugs, imaging agents, and other bioactive compounds into the pullulan nanoparticles to enhance the delivery efficiency or the cell uptake 28–32…”

Section: Introductionmentioning

confidence: 99%

“…26,27 Many researchers entrapped protein, anticancer drugs, imaging agents, and other bioactive compounds into the pullulan nanoparticles to enhance the delivery efficiency or the cell uptake. [28][29][30][31][32] In this work, we prepared a novel pH-sensitive DDS based on pullulan for delivery of DOX by a simple and easy scheme. Pullulan was partly carboxymethylized to introduce the carboxyl group onto the backbone.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

Lu¹,

Wen²,

Liang³

et al. 2008

J Biomed Mater Res

100

View full text Add to dashboard Cite

A novel pH-sensitive nanoparticle drug delivery system for doxorubicin (DOX) is prepared. Pullulan, a natural biocompatible polysaccharide, was partly carboxymethylized; hydrazine hydrate was condensed with the carboxyl groups forming hydrazide. The hydrazide was coupled with DOX through the formation of hydrazone bond. The chemical structure of the conjugate was determined by FTIR and (1)H NMR. The pullulan/DOX conjugate nanoparticles were formed through the aggregation of hydrophobic DOX. The size and morphology of prepared nanoparticles were characterized using dynamic light scattering and transmission electron microscope. The results showed that the nanoparticles were spherical and their size was less than 100 nm. The content of DOX in conjugate was 3.18 wt %. The investigation of the release behavior in vitro indicated that the DOX was released from nanoparticles faster at pH 5.0 (62% DOX released within 24 h) than at pH 7.4 (29% DOX released within 24 h). The in vitro cytotoxicity of pullulan/DOX conjugate nanoparticles was tested by the MTT assay.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

Lu¹,

Wen²,

Liang³

et al. 2008

J Biomed Mater Res

100

View full text Add to dashboard Cite

show abstract

“…Pullulan esterified with carboxylate could become a more stable carrier that can accept increased drug loading with larger encapsulation efficiency if there is an increase of the number of substituents such as deoxycholic acid (Na et al., 2006 ), folic acid (Kim et al., 2008 ), and polylactic acid (Miyazaki & Tabata, 2009 ; Okamoto et al., 2011 ). Drugs are released in a modified manner, and even an increased degree of acetylation of pullulan could decrease the release rate (Jung et al., 2003 ).…”

Section: Functionality Of Pullulan Nanogelsmentioning

confidence: 99%

Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Zhang

Yang

et al. 2018

Drug Delivery

View full text Add to dashboard Cite

Polymer nano-sized hydrogels (nanogels) as drug delivery carriers have been investigated over the last few decades. Pullulan, a nontoxic and nonimmunogenic hydrophilic polysaccharide derived from fermentation of black yeast like Aureobasidium pullulans with great biocompatibility and biodegradability, is one of the most attractive carriers for drug delivery systems. In this review, we describe the preparation, characterization, and ‘switch-on/off’ mechanism of typical pullulan self-assembled nanogels (self-nanogels), and then introduce the development of hybrid hydrogels that are numerous resources applied for regenerative medicine. A major section is used for biomedical applications of different nanogel systems based on modified pullulan, which exert smart stimuli-responses at ambient conditions such as charge, pH, temperature, light, and redox. Pullulan self-nanogels have found increasingly extensive application in protein delivery, tissue engineering, vaccine development, cancer therapy, and biological imaging. Functional groups are incorporated into self-nanogels and contribute to expressing desirable results such as targeting and modified release. Various molecules, especially insoluble or unstable drugs and encapsulated proteins, present improved solubility and bioavailability as well as reduced side effects when incorporated into self-nanogels. Finally, the advantages and disadvantages of pullulan self-nanogels will be analyzed accordingly, and the development of pullulan nanogel systems will be reviewed.

show abstract

“…At a high shear rate, the nanogels may become elongated, further reducing the apparent viscosity of the blood. Our group reported some findings regarding self-organizing nanogels consisting of a polysaccharide conjugated to a hydrophobic moiety [8,10,11]. However, despite their clear potential, polysaccharides have not been generally employed at a frequency comparable to synthetic polymers because they are difficult to modify and analyze, due to solvent issues.…”

Section: Introductionmentioning

confidence: 96%

Self-organized pullulan/deoxycholic acid nanogels: Physicochemical characterization and anti-cancer drug-releasing behavior

Cited by 26 publications

References 21 publications

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

A pH‐sensitive nano drug delivery system derived from pullulan/doxorubicin conjugate

Research progress of self-assembled nanogel and hybrid hydrogel systems based on pullulan derivatives

Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier

Contact Info

Product

Resources

About