Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier

Self-assembled nanoparticles of acetylated cashew gum: Characterization and evaluation as potential drug carrier

“…To measure the drug loading content, 5 mg of IND loaded nanoparticles were dissolved in DMSO (10 mL) and stirred for 1 h. The indomethacin content was determined by UV absorption at 319 nm (Shimadzu UV 1800 spectrometer) and it was calculated using a IND calibration curve relating absorbance and concentration. The drug load (DL) was calculated according to the following equation (Park et al, 2010):…”

“…Hydrophobized or hydrophobic polymers can self-assemble in aqueous solution forming nanoparticles. In this context, amphiphilic block copolymers and hydrophobized polymers have been previously synthesized and their structure-function relationships studied (Ding et al, 2011;Lee et al, 2012;Na et al, 2003;Suksiriworapong, Sripha, & Heinze, 2008;Lucero, Claro, Casas, & Jimenez-Castellanos, 2013), dextran (Hassani et al, 2012;Aumelas, Serrero, Durand, Dellacherie, & Leonard, 2007;Hornig, Bunjes, & Heinze, 2009;Nichifor, Lopes, Carpov, & Melo, 1999), pullulan (Lee et al, 2012;Zhang et al, 2009), chondroitin sulfate (Park et al, 2010), chitosan (Hassani et al, 2012;Hwang, Kim, Kwon, & Kim, 2008), hyaluronic acid (Surace et al, 2009), amylose (Lalush, Bar, Zakaria, Eichler, & Shimoni, 2005), heparin (Park et al, 2004) and curdlan (Na, Park, Kim, & Bae, 2000), amylopectin (Lu, Zhang, Wang, & Chen, 2011) alginate (Shi, Zhang, Qi, & Cao, 2012;Pawar & Edgar, 2012) have been used for the formation of self-assembling nanoparticles with a view to their application as drug carriers.…”

Bile acid-conjugated chondroitin sulfate A-based nanoparticles for tumor-targeted anticancer drug delivery

“…In addition to its binding affinity for the CD44 receptor, its hydrophilicity, biocompatibility, and biodegradability can provide preferable characteristics for the preparation of nanocarriers for intravenous administration [19,20]. Thus, chondroitin sulfate-based nanocarriers have been developed and evaluated for anticancer drug delivery [18,20,21].…”

Chondroitin sulfate-based nanocarriers for drug/gene delivery

“…As a naturally occurring anionic mucopolysaccharide, ChS is a biomaterial found in mammals particularly abundant in bone, cartilage, skin, ECM, nerve tissue and blood vessels (Cai et al, 2012;Park, Park, & Na, 2010). In biomedical field, ChS is used in the therapy of osteoarthritis as a type of neutraceuticals owing to its antiinflammatory activity (Iovu, Dumais, & Du Souich, 2008).…”