Self-organizing carbohydrate-oligothiophene-hybrids for eukaryotic membrane-labelling

Schmid, Sylvia; Schneider, E. M.; Brier, Eduard; Bäuerle, Peter

doi:10.1039/c4tb01472c

Cited by 6 publications

(4 citation statements)

References 43 publications

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“…[340] A similar effect was found for oligothiophenes having end-capping mannose groups. [332] In aqueous solution they form aggregates exhibiting weak emission (as mentioned in subsection 7.2.1). COEs incorporation in the biomembrane and internal compartments of myeloid cells resulted in green emission which could be observed by confocal microscopy.…”

Section: Living Cellsmentioning

confidence: 98%

“…[330] The side chains of CPs can also be tailored to enable selective targeting of certain cells through specific ligand-receptor interactions. [331,332]…”

Section: Mammalian Cellsmentioning

confidence: 99%

“…Another group synthesized COEs with mannose end-capping groups and thiophenebased backbone having different emission properties depending on their aggregation state. [332] In aqueous solution they formed aggregates exhibiting a non-structured fluorescence emission Researchers introduced COEs having donor and acceptor end-capping groups as polarizable and planarizable probes to sense the physical state of the biomembrane. [334] The π acceptor and π donor units at each end of the COEs backbone rendered them sensitive to biomembrane polarity, while the side methyl groups were responsible for the deplanarization of the conjugated backbone and sensitivity to lateral packing.…”

Section: Model Lipid Membranesmentioning

confidence: 99%

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Conjugated Polymers for Assessing and Controlling Biological Functions

et al. 2019

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The field of organic bioelectronics is advancing rapidly in the development of materials and devices to precisely monitor and control biological signals. Electronics and biology can interact on multiple levels: organs, complex tissues, cells, cell membranes, proteins, and even small molecules. Compared to traditional electronic materials like metals and inorganic semiconductors, conjugated polymers (CPs) have several key advantages for biological interactions; tunable physiochemical properties, adjustable form factors, and mixed conductivity (ionic and electronic). This review focuses on the use of CPs in five biologically oriented research topics: electrophysiology, tissue engineering, drug release, biosensing, and molecular bioelectronics. In electrophysiology, implantable devices with CP coating or CPonly electrodes are showing improvements in signal performance and tissue interfaces. CPbased scaffolds supply highly favorable static or even dynamic interfaces for tissue engineering.CPs also allow for delivery of drugs through a variety of mechanisms and form factors. For biosensing, CPs offer new possibilities to incorporate biological sensing elements in a conducting matrix. Molecular bioelectronics is today used to incorporate (opto)electronic functions in living tissue. Under each topic, limits of the utility of CPs are discussed and, overall, the review highlights the major challenges towards implementation of CPs and their devices to real-world applications.Received: ((will be filled in by the editorial staff))Revised: ((will be filled in by the editorial staff))

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Section: Living Cellsmentioning

confidence: 98%

“…[330] The side chains of CPs can also be tailored to enable selective targeting of certain cells through specific ligand-receptor interactions. [331,332]…”

Section: Mammalian Cellsmentioning

confidence: 99%

Section: Model Lipid Membranesmentioning

confidence: 99%

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Conjugated Polymers for Assessing and Controlling Biological Functions

et al. 2019

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“…12 Consequently, the choice of a proper side chain functionalization, combined with the intrinsic ability of PT backbones to reorganize upon external stimulation, offers the possibility to create new tools for sensing applications. Recently, also thiophene-based conjugated oligomers have gained increasing attention as conformationalsensitive fluorescent probes for biodiagnostic purposes, 13,14 after these oligomers have found extensive usage as a functional semiconductor material in organic electronics (e.g. field effect transistors, photovoltaic cells, electroluminescent devices).…”

Section: Introductionmentioning

confidence: 99%

Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine

et al. 2015

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Peptide π-Electron Conjugates: Organic Electronics for Biology?

2015

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Highly ordered arrays of π-conjugated molecules are often viewed as a prerequisite for effective charge-transporting materials. Studies involving these materials have traditionally focused on organic electronic devices, with more recent emphasis on biological systems. In order to facilitate the transition to biological environments, biomolecules that can promote hierarchical ordering and water solubility are often covalently appended to the π-electron unit. This review highlights recent work on π-conjugated systems bound to peptide moieties that exhibit self-assembly and aims to provide an overview on the development and emerging applications of peptide-based supramolecular π-electron systems.

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Self-organizing carbohydrate-oligothiophene-hybrids for eukaryotic membrane-labelling

Cited by 6 publications

References 43 publications

Conjugated Polymers for Assessing and Controlling Biological Functions

Conjugated Polymers for Assessing and Controlling Biological Functions

Acetylcholinesterase-induced fluorescence turn-off of an oligothiophene-grafted quartz surface sensitive to myristoylcholine

Peptide π-Electron Conjugates: Organic Electronics for Biology?

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