Self-Powered Biosensor for Specifically Detecting Creatinine in Real Time Based on the Piezo-Enzymatic-Reaction Effect of Enzyme-Modified ZnO Nanowires

Wang, Meng; Zi, Guangting; Liu, Jiajun; Song, Yutong; Zhao, Xishan; Wang, Qi; Zhao, Tianming

doi:10.3390/bios11090342

Cited by 11 publications

(6 citation statements)

References 43 publications

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“…A self-powered creatinine biosensor was reported by Wang et al [199]. The biosensor can detect the creatinine concentration based on the piezo-enzymatic reaction of the ZnO nanowires.…”

Section: Piezoelectric Biosensorsmentioning

confidence: 99%

“…A change in frequency occurs due to the interaction with target analytes, thus helping to determine the target analyte. 198 A self-powered creatinine biosensor was reported by Wang et al 199 The biosensor can detect creatinine concentration based on the piezo-enzymatic reaction of the ZnO nanowires. The detection range of the creatinine biosensor was measured to be around 1 Â 10 À5 -1 Â 10 À1 mM and the sensitivity was 0.0229 V mM À1 .…”

Section: Materials Advances Reviewmentioning

confidence: 99%

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A review on 2D-ZnO nanostructure based biosensors: from materials to devices

et al. 2023

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“…A self-powered creatinine biosensor was reported by Wang et al [199]. The biosensor can detect the creatinine concentration based on the piezo-enzymatic reaction of the ZnO nanowires.…”

Section: Piezoelectric Biosensorsmentioning

confidence: 99%

Section: Materials Advances Reviewmentioning

confidence: 99%

A review on 2D-ZnO nanostructure based biosensors: from materials to devices

et al. 2023

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“…The fabrication processes of SAW devices and their required circuits are often complex and expensive [ 13 , 14 ]. In contrast, capacitive and LC resonant sensors that operate with a varying capacitance are widely used due to their advantages such as good linearity, high sensitivity, low signal processing circuit complexity, and low power consumption [ 15 ]. The use of capacitive sensors for humidity testing is currently widespread; for example, the capacitive humidity sensors with different pore sizes based on nanoporous alumina manufactured by M. A. Mir and the capacitive humidity sensors with freestanding bendable porous SiO 2 manufactured by Soobin Park exhibit a good performance in humidity detection [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

GO/CNT−OH/Nafion Nanocomposite Humidity Sensor Based on the LC Wireless Method

Wang,

Jiao,

Wang

et al. 2023

Nanomaterials

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In recent years, LC resonant sensors have gained widespread attention for their extensive applications in industries such as pharmaceutical storage and food transportation. A wireless passive sensor with a good sensing performance is proposed based on a GO/CNT−OH/Nafion nanocomposite. The sensor was fabricated via inkjet printing technology, and the surface morphology of the GO/CNT−OH/Nafion nanocomposite was characterized by SEM measurement. It is found that the MWCNTs support the GO layer and the hydrophobic chains of Nafion interact with the hydrophobic layer of GO, resulting in a larger cavity and hydrophilic surface of the entire material. This structure well reflects the fact that the mixing of MWCNTs and Nafion provides the entire material with a stronger water absorption. The experimental study shows that the proposed humidity sensor has a frequency variation of 103 kHz/%RH at low humidity (30–60% RH) and a sensitivity of 931 kHz/%RH at high humidity (60–95% RH), while the sensitivity value from 30–95% RH is 547 kHz/% RH. The response time and recovery time are 110 s and 115 s, respectively. In addition, the tests showed that the GO/CNT−OH/Nafion nanocomposite applied to the humidity sensor had a maximum humidity hysteresis of about 3% RH at 30–95% RH, the resonant frequency remained basically unchanged after 50 h of testing, and the whole sensor possessed a good stability. After conducting several repeated experiments, it was found that the resonant frequency error of the whole sensor was low and did not affect the overall sensing test, which proved the reproducible preparation of the sensor. Finally, the humidity-sensing mechanism of the proposed sensor was analyzed in this paper, and it was found that GO enhanced the hygroscopic properties of GO/CNT−OH/Nafion nanocomposite when it was supported by MWCNT-OH and included uniformly dispersed Nafion. Therefore, our proposed humidity sensor is suitable for humidity detection above 30% RH in both sealed and open environments.

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“…The ACR (albumin-to-creatine ratio) is a significant prognostic marker for CKD patients [ 14 , 15 ] and is widely used as an early indicator of glomerular lesions [ 16 , 17 , 18 ] and for the on-going monitoring of diabetes and hypertension [ 19 , 20 ]. Notably, the ACR value can be determined from single urine samples and thus provides a more convenient diagnostic tool than 24-h urine tests [ 21 , 22 ]. The CRE in human urine determination is usually performed via a Jaffé kinetic assay, involving alkaline picric acid as the reagent [ 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Microfluidic Sliding Paper-Based Device for Point-of-Care Determination of Albumin-to-Creatine Ratio in Human Urine

et al. 2022

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A novel assay platform consisting of a microfluidic sliding double-track paper-based chip and a hand-held Raspberry Pi detection system is proposed for determining the albumin-to-creatine ratio (ACR) in human urine. It is a clinically important parameter and can be used for the early detection of related diseases, such as renal insufficiency. In the proposed method, the sliding layer of the microchip is applied and the sample diffuses through two parallel filtration channels to the reaction/detection areas of the microchip to complete the detection reaction, which is a simple method well suited for self-diagnosis of ACR index in human urine. The RGB (red, green, and blue) value intensity signals of the reaction complexes in these two reaction zones are analyzed by a Raspberry Pi computer to derive the ACR value (ALB and CRE concentrations). It is shown that the G + B value intensity signal is linearly related to the ALB and CRE concentrations with the correlation coefficients of R2 = 0.9919 and R2 = 0.9923, respectively. It is additionally shown that the ALB and CRE concentration results determined using the proposed method for 23 urine samples were collected from real suffering chronic kidney disease (CKD) patients are in fine agreement with those acquired operating a traditional high-reliability macroscale method. Overall, for point-of-care (POC) CKD diagnosis and monitoring in clinical applications, the results prove that the proposed method offers a convenient, real time, reliable, and low-spending solution for POC CKD diagnosis.

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Self-Powered Biosensor for Specifically Detecting Creatinine in Real Time Based on the Piezo-Enzymatic-Reaction Effect of Enzyme-Modified ZnO Nanowires

Cited by 11 publications

References 43 publications

A review on 2D-ZnO nanostructure based biosensors: from materials to devices

A review on 2D-ZnO nanostructure based biosensors: from materials to devices

GO/CNT−OH/Nafion Nanocomposite Humidity Sensor Based on the LC Wireless Method

Microfluidic Sliding Paper-Based Device for Point-of-Care Determination of Albumin-to-Creatine Ratio in Human Urine

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