Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip

Yeh, Erh-Chia; Fu, Chi-Cheng; Hu, Lucy; Thakur, Rohan; Feng, Jeffrey; Lee, Luke P.

doi:10.1126/sciadv.1501645

Cited by 298 publications

(257 citation statements)

References 52 publications

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“…Three distinguished branches with hydrophobic barriers made of SU-8 photoresist were patterned on chromatography paper using photolithography process and used for glucose and albumin detection. Since the development of 2D-l PAD, extensive research has been carried out in device design, performance improvement and their utilization in various point-of-care applications in the past decades (Cate et al 2014;Kumar et al 2016aKumar et al , b, 2017aKumar et al , b, 2018Morbioli et al 2017;Li et al 2017;You et al 2017;Yeh et al 2017;Whitesides 2018).…”

Section: Paper Microfluidics: Historical Perspectivementioning

confidence: 99%

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

Kumar

Bhushan

Ágarwal

et al. 2019

Advanced Functional Materials and Sensors

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Paper-based microfluidic systems have emerged as one of the most favorable technologies used in many potential applications such as point-of-care diagnostics, flexible electronics, energy storage, etc. From the past several decades, paper-based technology has readily accepted in the academic research lab and industries as well. The paper-based devices have changed the life of humankind. The distinguishing characteristics of paper substrate like low cost, biodegradability, biocompatibility, and ease of fabrication helped their adaptability in biosensing applications. This chapter gives a concise overview of the historical perspective of paper-based devices, classification of paper types, and their recent applications.

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Section: Paper Microfluidics: Historical Perspectivementioning

confidence: 99%

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

Kumar

Bhushan

Ágarwal

et al. 2019

Advanced Functional Materials and Sensors

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“…To adapt this need to POC settings, research teams used miniaturized sources of electricity, such as commercial heat packs . Others developed electricity‐free devices, generating power or heat through chemical reaction or paper‐based batteries.…”

Section: Detectionmentioning

confidence: 99%

“…LODs use the various forces created by its rotation to drive flow between its different modules. A vacuum battery, able to suck liquids by releasing a vacuum that is pre‐stored in PDMS pouches, was inserted into a fully integrated diagnostic microfluidic device . Automation of flow control may also involve the insertion of microvalves into the device in order to compartmentalize the different operations performed within it.…”

Section: Integrationmentioning

confidence: 99%

Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

Duchesne

Lacombe

2017

Journal of Viral Hepatitis

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According to the Global Burden of Diseases, chronic viral hepatitis B and C are one of the most challenging global health conditions that rank among the first causes of morbidity and mortality worldwide. Low- and middle-income countries are particularly affected by the health burden associated with HBV or HCV infection. One major gap in efficiently addressing the issue of viral hepatitis is universal screening. However, the costs and chronic lack of human resources for using traditional screening strategies based on serology and molecular biology preclude any scaling-up. Point-of-care tests have been deemed a powerful potential solution to fill the current diagnostics gap in low-resource and decentralized settings. Despite high interest resulting from their development in recent years, very few point-of-care devices have reached the market. Scaling down and automating all testing steps in 1 single device (eg, sample preparation, detection and readout) is indeed challenging. But innovations in multiple disciplines such as nanotechnologies, microfluidics, biosensors and synthetic biology have led to the creation of chip-sized laboratory systems called "lab-on-a-chip" devices. This review aims to explain how these innovations can overcome technological barriers that usually arise for each testing step while developing integrated point-of-care tests. Point-of-care test prototypes rarely meet the requirements for mass production, which also hinders their large-scale production. In addition to logistical hurdles, legal and economic constraints specific to the commercialization of in vitro diagnostics, which have also participated in the low transfer of innovative point-of-care tests to the field, are discussed.

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“…Analytical systems that can reliably, sensitively, and rapidly identify a range of chemical compounds and biomarkers would have broad applications in biomedical research and clinical diagnostics (Giljohann and Mirkin, 2009; Gaster et al, 2011; Abbott et al, 2017; Yeh et al, 2017). Nuclear magnetic resonance (NMR) is a powerful analytical technique valued for its non-destructive detection capability (Lacey et al, 1999; Demas et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Multichannel digital heteronuclear magnetic resonance biosensor

Huber

Min

Staat

et al. 2019

Biosensors and Bioelectronics

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Low-field, mobile NMR systems are increasingly used across diverse fields, including medical diagnostics, food quality control, and forensics. The throughput and functionality of these systems, however, are limited due to their conventional single-channel detection: one NMR probe exclusively uses an NMR console at any given time. Under this design, multi-channel detection could only be accomplished by either serially accessing individual probes or stacking up multiple copies of NMR electronics; this approach still retains limitations such as long assay times and increased system complexity. Here we present a new scalable architecture, HERMES (hetero-nuclear resonance multichannel electronic system), for versatile, high-throughput NMR analyses. HERMES exploits the concept of software-defined radio by virtualizing NMR electronics in the digital domain. This strategy i) creates multiple NMR consoles without adding extra hardware; ii) acquires signals from multiple NMR channels in parallel; and iii) operates in wide frequency ranges. All of these functions could be realized on-demand in a single compact device. We interfaced HERMES with an array of NMR probes; the combined system simultaneously measured NMR relaxation from multiple samples and resolved spectra of hetero-nuclear spins (1H, 19F, 13C). For potential diagnostic uses, we applied the system to detect dengue fever and molecularly profile cancer cells through multi-channel protein assays. HERMES holds promise as a powerful analytical tool that enables rapid, reconfigurable, and parallel detection.

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Self-powered integrated microfluidic point-of-care low-cost enabling (SIMPLE) chip

Abstract: Using lab-on-chip technology, bulky lab equipment is shrunk into a simple, portable, and quantitative microfluidic chip for DNA diagnostics.

Cited by 298 publications

References 52 publications

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

A Historical Perspective on Paper Microfluidic Based Point-of-Care Diagnostics

Innovative technologies for point‐of‐care testing of viral hepatitis in low‐resource and decentralized settings

Multichannel digital heteronuclear magnetic resonance biosensor

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