Self‐Propelled Rolled‐Up Polyelectrolyte Multilayer Microrockets

Hu, Narisu; Sun, Mengmeng; Lin, Xiankun; Gao, Changyong; Zhang, Bin; Zheng, Ce; Xie, Hui; He, Qiang

doi:10.1002/adfm.201705684

Cited by 52 publications

(31 citation statements)

References 52 publications

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“…He, [182] who demonstrated the fabrication of self-propelled chitosan/alginate polyelectrolyte multilayer (PEM) microsized films onto poly(vinylalcohol) (PVA) coated glass slides ( Figure 6 A-C). These PEM systems have a spontaneous rolling behavior and ultimately give rise to microrockets when in presence of platinum nanoparticles, which can catalyze the decomposition of H2O2 into water and gaseous oxygen.…”

Section: Dna-rich Microcompartmentsmentioning

confidence: 99%

Artificial Biosystems by Printing Biology

Arrabito

Ferrara

Bonasera

et al. 2020

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The continuous progress of printing technologies over the past 20 years has fueled the development of a wide plethora of applications in materials sciences, flexible electronics and biotechnologies. More recently, printing methodologies have started up to explore the world of Artificial Biology, offering new paradigms in the direct assembly of Artificial Biosystems (small condensates, compartments, networks, tissues and organs) by mimicking the result of the evolution of living systems and also by redesigning natural biological systems, taking inspiration from them. This recent progress is reported in terms of a new field here defined as Printing Biology, resulting from the intersection between the field of printing and the bottom up Synthetic Biology. Printing Biology explores new approaches for the reconfigurable assembly of designed lifelike or life-inspired structures. This review presents this emerging field, highlighting its main features, i.e. printing methodologies (from 2D to 3D), molecular ink properties, deposition mechanisms, and finally the applications and future challenges. Printing Biology is expected to show a growing impact on the development of biotechnology and lifeinspired fabrication. Printing Biology employs different technologies dispensing molecular inks with tunable composition (molecules, polymers, biomolecules) and drop sizes (from nano-up to macroscale) onto solids or into liquids to develop lifelike or life-inspired artificial biosystems (from small condensates, to compartments up to networks, tissues and organs). This work reviews the extraordinary potential of this emerging research field.

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Section: Dna-rich Microcompartmentsmentioning

confidence: 99%

Artificial Biosystems by Printing Biology

Arrabito

Ferrara

Bonasera

et al. 2020

Small

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“…Due to their efficient propulsion with remarkable speeds, high power and cargo-towing ability, precise motion control, and design versatility, such chemically powered microrockets have already proven to be capable for performing various biomedical tasks. [4,5,9,10] Particularly attractive for in vivo operations are zinc (Zn)-based microrockets that display efficient self-propulsion in acidic environments, such as the stomach gastric fluid (GF), without the DOI: 10.1002/adhm.202000900 need for any additional chemical fuel. [11] Different designs of such acid-powered Znmicrorockets have demonstrated efficient cargo-loading capacity with autonomous release.…”

Section: Introductionmentioning

confidence: 99%

Zinc Microrocket Pills: Fabrication and Characterization toward Active Oral Delivery

Mundaca‐Uribe

Ávila

Holay

et al. 2020

Adv Healthcare Materials

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Here the fabrication of a zinc (Zn) microrocket pill is reported, and its unique features toward active and enhanced oral delivery application are demonstrated. By loading Zn‐based tubular microrockets into an orally administrable pill formulation, the resulting Zn microrocket pill can rapidly dissolve in the stomach, releasing numerous encapsulated Zn microrockets that are instantaneously activated and then propel in the gastric fluid. The released Zn microrockets display efficient propulsion without being affected by the presence of the inactive excipient materials of the pill. An in vivo retention study performed in mice clearly shows that the active pill dissolution and powerful acid‐driven Zn microrocket propulsion greatly enhance the microrocket retention within the gastric tissue without causing toxic effects. By combining the active delivery feature of Zn microrockets with the oral administration of a pill, the Zn microrocket pill holds considerable potential for active oral delivery of various therapeutics for diverse medical applications.

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“…To further push the micro/nanorobots field to real‐world applications, one has to develop objects, whose synthesis is easily scalable . The scalability is a property hard to fulfill for the planar‐based techniques (rolled‐up planar nanolayers, electrochemical template pore deposition). The answer to the problem is approached by wet‐chemical synthesis of micro/nanoparticles directly in solution, where the primary challenge is to introduce a highly asymmetrical component into the particle, to use it for directional self‐propulsion …”

Section: Introductionmentioning

confidence: 99%

Plasmonic Self‐Propelled Nanomotors for Explosives Detection via Solution‐Based Surface Enhanced Raman Scattering

Novotný

Plutnar

Pumera

2019

Adv Funct Materials

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Nanomotors represent a class of artificial machines that span the chasm between molecular motors and bigger micromotors. Their importance lies in the fact that to effectively navigate and perform tasks in a biological environment without alerting the action of the immune system, the maximal size of the object has to be well below 200 nm. Fully nanosized gold/silver core/shell plasmonic nanomotors using the seeded growth wet chemical approach, which allows high scalability of synthesis of the nanomotors compared to planar substrate-based methods, is presented. Using the nanoparticle tracking analysis, the catalysis driven enhanced diffusion of the plasmonic nanomotors in the presence of low concentrations of fuel is presented and shown that the prepared nanomotors are good candidates for a solutionbased surface-enhanced Raman spectroscopy detection of picric acid, a typical explosive. In addition to the mentioned effects, ligand-exchange is performed on the nanomotors to replace the surfactant with its thiolated analog, a combination which is already proven in literature to be stealthy to the immune response of the living organism.The ORCID identification number(s) for the author(s) of this article can be found under https://doi.org/10.1002/adfm.201903041. microjets, [8][9][10][11] Janus particles, [5,12,13] and particle dimers [11] in the past years, showing the possibility to construct micrometer-sized objects with physically and chemically programmed behavior for a specific environment and specific stimuli. [5,14] Such programmed behavior patterns include catalytically driven bubble-jet propulsion, [8] self-electrophoresis, [15][16][17] self-diffusiophoresis, [15,17] selfthermophoresis, [12,17] which are connected to response to external magnetic, [18] electric, [19] or electromagnetic field [20,21] and also to concentration gradients of chemical substances. [22] These micromachines are proposed to be used in biomedicinal [3] and environmental [4,6] as well as in military applications. [23] Applications of micromotors in sensing of small molecules are also developed but in much smaller extent. The sensing is usually based on (i) slowing the micromotors down by catalyst poisoning or accelerating them by providing fuel, [24,25] (ii) aggregation of the micromotors to produce higher concentrations of an analyte [26] or (iii) separation of the sensing of an analyte by collecting the micromotors be sedimentation. [26] However, direct sensing by micromotors is limited.While the area of self-propelled micromachines is well developed, the field of nanorobots, i.e., self-propelled devices of submicrometer size, is developed much less. For any micro-or nanorobots to have real-world impact, we have to use millions and billions of them. Most of the works in the field use planar substrate-based preparation technique. [17] To further push the micro/nanorobots field to real-world applications, one has to develop objects, whose synthesis is easily scalable. [27] The scalability is a property hard to fulfill for the planar-based...

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Self‐Propelled Rolled‐Up Polyelectrolyte Multilayer Microrockets

Cited by 52 publications

References 52 publications

Artificial Biosystems by Printing Biology

Artificial Biosystems by Printing Biology

Zinc Microrocket Pills: Fabrication and Characterization toward Active Oral Delivery

Plasmonic Self‐Propelled Nanomotors for Explosives Detection via Solution‐Based Surface Enhanced Raman Scattering

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