We report the first demonstration of a portable HTS monolithic microwave integrated circuit (MMIC) receiver front-end module operating on a commercial mini cryocooler. The HTS circuit consists of a step-edge junction mixer and a number of HTS filters fabricated on a single MgO substrate. The HTS MMIC circuit is integrated with the mini cryocooler. The sample vacuum chamber, cold-head, compressor and cooling fans are all packed into one customer-designed portable box of approximately 350 mm × 350 mm × 250 mm in dimension. The HTS Josephson junction-based microwave circuit operated successfully in the cryocooler unshielded without observable performance degradation. The design and implementation of the compact unit and performance evaluation of a HTS MMIC frequency down-converter are presented. Index Terms-High-temperature superconductor, Josephson mixer, receiver front-end, mini cryocooler. Manuscript received August 12, 2014. J. Du is with CSIRO Future Manufacturing Flagship, PO Box 218,