Self-reported Breast Implants and Connective-Tissue Diseases in Female Health Professionals

Hennekens, Charles H.

doi:10.1001/jama.1996.03530320040032

Cited by 137 publications

(26 citation statements)

References 27 publications

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“…Most published epidemiological studies have found little, if any, evidence of systemic autoimmune disease associated with SBI (2,3,6,14,17). However, many of these retrospective studies were limited to detecting an increased frequency of classic autoimmune and/or clinically defined diseases.…”

mentioning

confidence: 99%

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Naim¹,

Satoh

Buehner³

et al. 2000

Clin Diagn Lab Immunol

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Although most published epidemiological studies have found little evidence of systemic autoimmune disease associated with silicone breast implants, there still remains a question of whether silicones can cause local and/or systemic immune dysfunction. This study further investigates the effects of silicones on autoantibody and immunoglobulin production and macrophage activation in female A.SW mice. Sixty mice were divided among four treatment groups receiving a 0.5-ml intraperitoneal injection of either phosphate-buffered saline (PBS), pristane, silicone gel, or silicone oil. Test bleeds were taken periodically for 6 months. In contrast to pristane, neither silicone gel nor silicone oil induced lupus-associated antinuclear autoantibodies (immunoglobulin G [IgG] anti-nRNP/Sm, Su, and ribosomal P) or lupus nephritis. However, serum IgM became elevated persistently within 1 month of silicone gel or silicone oil administration. Also, the level of IgG3 was clearly elevated in silicone oil-treated mice. In contrast, IgG1, IgG2a, and IgG2b levels were not affected greatly by either silicone gel or oil. Furthermore, peritoneal macrophages from silicone-and pristane-treated mice produced higher levels of interleukin-1␤ (IL-1␤) and IL-6 than those from PBS-treated mice after lipopolysaccharide stimulation. These results suggest that silicone gels and oils are capable of inducing hypergammaglobulinemia and activating macrophages in female A.SW mice.

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mentioning

confidence: 99%

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Naim¹,

Satoh

Buehner³

et al. 2000

Clin Diagn Lab Immunol

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“…We did not find a relationship between increased SRSC complaints and ANA positivity or MRI changes in the silicone prostheses 1 year after SBI. While awaiting the results of the prospective study with a third measurement of SRSC-related complaints and ANA, we accept the conclusions from large retrospective cohort studies which could not find any risk of connective tissue disease in association with silicone prostheses [10,11,[28][29][30].…”

Section: Discussionmentioning

confidence: 75%

A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex

et al. 2002

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This cohort study prospectively evaluated the prevalence of the silicone-related symptom complex (SRSC) in relation to antinuclear antibodies (ANA) and magnetic resonance imaging (MRI) of silicone breast implants (SBI) 1 year after implantation. A total of 57 women undergoing mastectomy followed by immediate breast reconstruction (IBR) and SBI between March 1995 and March 1997 at the University Hospital Rotterdam/Daniel den Hoed Cancer Centre, were prospectively evaluated. Just before and 1 year after IBR the sera of these women were tested for the presence of ANA and they were screened for the prevalence of SRSC-related symptoms by questionnaire. All prostheses were evaluated by MRI 1 month and 1 year after IBR. Just before operation 11% of the women had a Sjögren score of more than 2, whereas 30% had such a score 1 year after IBR ( P = 0.01). One year postoperatively women had significantly more RA/Raynaud-related complaints: 21% preoperatively versus 40% 1 year after IBR ( P = 0.03). Within the undefined complaints-related group 19% had a score of 2 or more preoperatively and 33% 1 year after IBR ( P = 0.09). There were no new cases of ANA positivity 1 year after IBR. The linguine sign was seen by MRI in three implants: one 1 month after IBR and two 1 year after IBR. There was no relation to changes in SRSC expression and these MRI findings. In conclusion, 1 year after SBI implantation women had more SRSC-related complaints, especially Sjögren's and RA/Raynaud's. Moreover there was no correlation between elevated SRSC expression and changes in the presence of ANA or changes in MRI of the SBI 1 year after IBR.

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“…The methods used in this study are already published in a retrospective study (Contant et al, 2000b). Awaiting the results of this prospective study the conclusions from the literature that there is no evidence for a silicone-related syndrome are conformed (Gabril et al, 1994, Hennekens et al, 1996, Noone et al, 1997, Sanchez-Guerrero et al, 1995.…”

Section: Discussionmentioning

confidence: 91%

Satisfaction and prosthesis related complaints in women with immediate breast reconstruction following prophylactic and oncological mastectomy

Contant

Wersch

Menke-Pluymers

et al. 2004

Psychology, Health & Medicine

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Aim: This study evaluated patient"s satisfaction with immediate breast reconstruction (IBR) with silicone prosthesis. Special attention is paid to the differences in satisfaction, and specific prosthesis related complaints of IBR after prophylactic and oncological mastectomy. Results:The most important perceived advantage of IBR was not to have to wear an external prosthesis (95%). Despite the fact that one third of the patients had specific prosthesis related complaints, 80% was satisfied with IBR and 88% would do it again. There was no significant difference in satisfaction between the prophylactic and the cancer group. Overall satisfaction is mostly influenced by cosmetics (r =-.58), information (r =-.45) and specific prosthesis related complaints (r =-.39). Especially specific prosthesis related complaints are important for both the prophylactic and the cancer group. Conclusions:The majority of patients were satisfied with IBR after oncological or prophylactic mastectomy. However the findings of the importance of specific prosthesis related complaints should be taken serious for the information and care of patients.Keywords: immediate breast reconstruction, silicone prosthesis, oncological and prophylactic mastectomy 3

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Self-reported Breast Implants and Connective-Tissue Diseases in Female Health Professionals

Cited by 137 publications

References 27 publications

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

Induction of Hypergammaglobulinemia and Macrophage Activation by Silicone Gels and Oils in Female A.SW Mice

A Prospective Study on Silicone Breast Implants and the Silicone-Related Symptom Complex

Satisfaction and prosthesis related complaints in women with immediate breast reconstruction following prophylactic and oncological mastectomy

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