Self-reported Improvement in Side Effects and Quality of Life With Integrative Medicine in Breast Cancer Patients

Hack, Carolin C.; Hackl, Janina; Hüttner, N. B. M.; Langemann, Hanna; Schwitulla, Judith; Dietzel-Drentwett, Svenja; Fasching, Peter A.; Beckmann, Matthias W.; Theuser, Anna-Katharin

doi:10.1177/1534735418777883

Cited by 12 publications

(13 citation statements)

References 49 publications

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“…Recently, several integrative therapies have been proposed for the treatment of BC patients in order to improve the efficacy of standard anticancer approaches, reduce chemotherapy side effects, ameliorate patient quality of life, and to reduce BC mortality [5][6][7]. Currently adopted integrative therapies for BC patients include nutraceutical products like vitamins, flavonoids and natural extracts [8,9], prebiotics and probiotics [10,11], the adoption of a healthy lifestyle mainly represented by moderate or intense physical exercise [12,13], and the adherence to healthy or hypocaloric diets [5,14].…”

Section: Introductionmentioning

confidence: 99%

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Falzone

Grimaldi

Celentano

et al. 2020

Cancers

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Background: Several studies have shown that healthy lifestyles prevent the risk of breast cancer (BC) and are associated with better prognosis. It was hypothesized that lifestyle strategies induce microRNA (miRNA) modulation that, in turn, may lead to important epigenetic modifications. The identification of miRNAs associated with BC, diet, and physical activity may give further insights into the role played by lifestyle interventions and their efficacy for BC patients. To predict which miRNAs may be modulated by diet and physical activity in BC patients, the analyses of different miRNA expression datasets were performed. Methods: The GEO DataSets database was used to select miRNA expression datasets related to BC patients, dietary interventions, and physical exercise. Further bioinformatic approaches were used to establish the value of selected miRNAs in BC development and prognosis. Results: The analysis of datasets allowed the selection of modulated miRNAs associated with BC development, diet, and physical exercise. Seven miRNAs were also associated with the overall survival of BC patients. Conclusions: The identified miRNAs may play a role in the development of BC and may have a prognostic value in patients treated with integrative interventions including diet and physical activity. Validation of such modulated miRNAs on BC patients undergoing lifestyle strategies will be mandatory.

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Section: Introductionmentioning

confidence: 99%

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Falzone

Grimaldi

Celentano

et al. 2020

Cancers

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“…As stimulation effects have been reported for this formulation 17 , it is recommended for patients with fatigue and lack of motivation. Fatigue is one of the most common side effects of breast cancer therapy reported by patients in an integrative medicine setting 35 . This offers an explanation why the IMed regeneration infusion is the most commonly used infusion by patients in this study.…”

Section: Discussionmentioning

confidence: 99%

“…Aufgrund der nachgewiesenen stimulierenden Wirkungen dieser Formulierung 17 wird diese für Patienten mit Fatigue und Antriebslosigkeit empfohlen. Fatigue zählt zu den häufigsten Nebenwirkungen einer Brustkrebstherapie, über die Patientinnen im Setting der integrativen Medizin berichten 35 . Dies erklärt auch, weshalb die IMed-Regenerationsinfusion bei unseren Studienpatientinnen die am häufigsten angewendete Infusion darstellt.…”

Section: Diskussionunclassified

Supportive Infusions in Integrative Breast and Gynecological Oncology – Report on Patientsʼ Satisfaction and Self-reported Effects and Side Effects

Hack

Antoniadis

Beckmann

et al. 2018

Geburtshilfe Frauenheilkd

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Background During cancer therapy, many patients suffer from malnutrition or vitamin deficiency. Treatment for nutrition-related deficiencies should therefore include nutritional therapy and possibly oral or intravenous substitution of micronutrients. Little information exists on multinutrient infusion therapies. The aim of this study was to develop standardized infusion protocols for integrative medicine infusions with micronutrients (IMed infusions) and to report on side effects of the treatment and patientsʼ satisfaction with it. Methods For the IMed consultancy service, four special formulas for intravenous use were developed in cooperation with the pharmacy at Erlangen University Hospital. A retrospective cross-sectional study was conducted between October 2015 and January 2018 in which 45 patients with gynecological or breast cancer (BC) and IMed infusion therapy were included. Follow-up data were obtained from 20 patients using a standardized questionnaire on IMed infusions. Results A total of 280 IMed infusions were administered in the study period. The majority of the patients received an IMed regeneration infusion (78%). The majority of the patients had BC and were receiving chemotherapy. Most patients reported a high or very high level of satisfaction with the organization (60%), general treatment (65%) and counseling (85%). Subjective improvement in their disease-related and therapy-induced symptoms, such as fatigue, polyneuropathy and physical efficiency, was reported by 70% of the patients, while 75% reported a subjective increase in quality of life. Side effects were rare and minor. Conclusions Therapy with IMed infusions in women with BC or gynecological cancer requires the same standards set for drug therapy. Although vitamins represent dietary supplements, appropriate assessment of the patientʼs medical history is needed and patients must receive appropriate information. For this purpose, standardized processes, as in the context of an IMed consultancy service, are helpful.

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“…The standardized follow-up questionnaire included questions on treatment compliance, physical and mental state, therapy goals, improvement in side effects, and quality of life. 34 The overall study plan and analyses of side effects and quality of life have been published in an earlier article. 28 , 34 Both the baseline questionnaire and the standardized follow-up questionnaire have been published previously.…”

Section: Methodsmentioning

confidence: 99%

“… 28 , 34 Both the baseline questionnaire and the standardized follow-up questionnaire have been published previously. 33 , 34 …”

Section: Methodsmentioning

confidence: 99%

Active Participation, Mind–Body Stabilization, and Coping Strategies with Integrative Medicine in Breast Cancer Patients

et al. 2021

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Purpose: Increasing numbers of breast cancer survivors have led to a growing demand for integrative medicine. When patients have completed treatments associated with severe side effects, attention turns to reducing psychological symptoms, coping behavior, and self-care. The aim of this study was to assess patient-reported benefits in relation to active participation, mind–body stabilization, and coping strategies in breast cancer patients receiving integrative medicine. Methods: In a cross-sectional study, health counseling and treatment provided by a standardized integrative medicine consultancy service at the University Breast Center of Franconia were evaluated in 75 breast cancer patients over a 15-month period. At the baseline, the patients answered a questionnaire on their medical history, symptoms, and the treatment goals they were hoping to achieve with integrative medicine. Patient-reported outcomes relative to active participation, mind–body stabilization, and coping strategies were analyzed. Results: A large majority of the patients had previous experience with integrative medicine (91%). Most reported that they achieved their treatment goals with integrative medicine. Ninety-one percent achieved active participation in cancer treatment, 90% mind–body stabilization, and 79% improvement in coping strategies. Besides active participation, which was greatest in patients with stable disease, the success of integrative therapy was independent of age, concomitant diseases, previous integrative medicine experience, treatment state, and systemic cancer therapy. Conclusion: Breast cancer patients benefit from the counseling and treatment provided with integrative medicine in mind–body stabilization and coping with cancer. Active participation in cancer treatment is important for the patients. Integrative treatment services should form part of routine patient care.

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Self-reported Improvement in Side Effects and Quality of Life With Integrative Medicine in Breast Cancer Patients

Cited by 12 publications

References 49 publications

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Identification of Modulated MicroRNAs Associated with Breast Cancer, Diet, and Physical Activity

Supportive Infusions in Integrative Breast and Gynecological Oncology – Report on Patientsʼ Satisfaction and Self-reported Effects and Side Effects

Active Participation, Mind–Body Stabilization, and Coping Strategies with Integrative Medicine in Breast Cancer Patients

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