Self-Templated Synthesis of Triphenylene-Based Uniform Hollow Spherical Two-Dimensional Covalent Organic Frameworks for Drug Delivery

Du, Changsheng; Na, Wenjing; Shao, Mingchao; Shang, Shengcong; Liu, Yunqi; Chen, Jianyi

doi:10.1021/acs.chemmater.2c03469

Cited by 23 publications

(19 citation statements)

References 41 publications

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“…31,42 Hollow COFs are a kind of valuable alternative material in biomedical applications. To date, several hollow COF materials have been fabricated and utilized for biomedical applications, such as drug delivery, 20,31,73 therapy, 34,42,112 in vivo imaging, 40 and fluorescence sensing. 113 In a study conducted by Banerjee et al, hollow spherical COFs were synthesized, and their potential as drug delivery vehicles were evaluated.…”

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

“…In brief, numerous hollow COFs with desired morphologies and constituents have been successfully prepared by different synthetic methods. Currently, most of the reported hollow COFs feature hexagonal pore structures, and only a few studies have reported the synthesis of hollow COFs featuring other types of pores, including trigonal, tetragonal, and rhombic pores. ,,, To meet the requirements for practical applications, the preparation of hollow COFs with diverse topological structures through elaborate design is of great interest. By taking advantage of various synthetic methodologies, hollow COFs with different types of pores are highly expected.…”

Section: Synthesis Of Hollow Cofs and Their Derivativesmentioning

confidence: 99%

“…Attributed to their high chemical stability, absence of metal ions, large specific surface area, and well-confined hollow structure, hollow COFs have incomparable advantages, including high loading ability, controllable release, and good biocompatibility. , Hollow COFs are a kind of valuable alternative material in biomedical applications. To date, several hollow COF materials have been fabricated and utilized for biomedical applications, such as drug delivery, ,, therapy, ,, in vivo imaging, and fluorescence sensing …”

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

“…The slow and sustained release of doxorubicin, with 42% released after 7 days, highlights the potential of hollow COFs as a promising candidate for drug delivery. Similarly, Chen et al constructed three hollow spherical two-dimensional COFs through a self-template method . The resulting hollow COFs turned out to be superior nanocarriers for efficient controlled drug delivery because of their uniform morphology, large specific surface area, and high crystallinity.…”

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

“…Similarly, Chen et al constructed three hollow spherical two-dimensional COFs through a selftemplate method. 73 The resulting hollow COFs turned out to be superior nanocarriers for efficient controlled drug delivery because of their uniform morphology, large specific surface area, and high crystallinity. Building upon these findings, researchers have also developed smart drug release systems, such as pH-sensitive 31 and electric-stimulus responsive systems, 42 thereby allowing the development of accurate targeted and controlled drug release technology.…”

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

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Nanoarchitectonics of Hollow Covalent Organic Frameworks: Synthesis and Applications

et al. 2023

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Hollow covalent organic frameworks (COFs) have gained significant attention because of their specific properties, including enhanced surface-to-volume ratio, large surface area, hierarchical structure, highly ordered nanostructures, and excellent chemical stability. These intrinsic characteristics endow hollow COFs with fascinating physicochemical properties and make them highly attractive for widespread applications, such as catalysis, energy storage, drug delivery, therapy, sensing, and environmental remediation. This review focuses on the recent developments in the synthesis of hollow COFs and their derivatives. In addition, their practical applications in various fields are summarized. Finally, challenges and future opportunities in terms of their synthetic methodologies and practical applications are discussed. Hollow COFs are expected to play an important role in the future of materials science.

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Section: Applications Of Hollow Cofsmentioning

confidence: 99%

Section: Synthesis Of Hollow Cofs and Their Derivativesmentioning

confidence: 99%

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

Section: Applications Of Hollow Cofsmentioning

confidence: 99%

See 3 more Smart Citations

Nanoarchitectonics of Hollow Covalent Organic Frameworks: Synthesis and Applications

et al. 2023

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A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

Mehvari,

Ramezanzade,

Asadi

et al. 2024

Aggregate

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The development of efficient drug delivery systems is essential for improving the efficacy and safety of cancer drugs, particularly for aggressive and difficult‐to‐treat cancers. Covalent organic frameworks (COFs) are emerging as innovative porous nanomaterials in drug delivery systems (DDS), due to their unique properties, including the metal‐free organic skeleton, predetermined structures and pore geometries, high porosity, large surface area, facile surface modification potential, and good biocompatibility. These characteristics make COFs excellent candidates for improving drug delivery by enhancing drug loading capacity and enabling precise encapsulation. This review emphasizes the importance of donor‐acceptor‐based COFs, which provide channels for charge transportation, and we also explore how the π‐conjugated skeleton of COFs enhances its long‐acting fluorescent properties and facilitates drug uptake via cell endocytosis. While this review primarily focuses on recent advancements in COF‐based targeted DDS, it also acknowledges the challenges posed by the diverse pore geometries in porous materials and discusses potential solutions. Further, it underlines the potential of developing future drug carriers that can successfully and specifically target cancer cells, improving treatment efficiency while reducing adverse side effects.

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One‐Pot N‐Alkylation of Amines over Ni(II) Embedded Reusable Porous Organic Polymer via Borrowing Hydrogen Strategy

Pathak,

Kumar Kalita,

Sharma

et al. 2024

ChemCatChem

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The first‐of‐its‐kind, one‐pot N‐alkylation reaction of amines over Ni(II) impregnated porous organic polymer of highly dense N‐rich skeleton is reported. The primeval Ni(II) decorated hollow spherical porous polymer is synthesized and employed in a series of catalytic reactions involving C–N bond formation. The catalytic reactions are optimised to yield the desired product highlighting the role of different substituents present on the reactants towards the overall selectivity and efficiency. The detailed reaction mechanism is corroborated with computation validating a three‐step arrow formalism viz. dehydrogenation of the alcohol, condensation with amines to generate the imine as intermediate followed by hydrogenation by a borrowing strategy to yield the final product. The role of the bare support material in the first step and that of the Ni(II) centres of the support material in the third step is marked as pivotal for the forward reaction to proceed with enriching sustainability and feasibility.

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Self-Templated Synthesis of Triphenylene-Based Uniform Hollow Spherical Two-Dimensional Covalent Organic Frameworks for Drug Delivery

Cited by 23 publications

References 41 publications

Nanoarchitectonics of Hollow Covalent Organic Frameworks: Synthesis and Applications

Nanoarchitectonics of Hollow Covalent Organic Frameworks: Synthesis and Applications

A panoramic perspective of recent progress in 2D and 3D covalent organic frameworks for drug delivery

One‐Pot N‐Alkylation of Amines over Ni(II) Embedded Reusable Porous Organic Polymer via Borrowing Hydrogen Strategy

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