Seltener niedrig-maligner Tumor der Kopfhaut

Abstract

A 79-year-old patient presented with an asymptomatic scalp tumor which had grown over the past 9 months. Based on clinical, histological and immunohistochemical staining, we made the diagnosis of an atypical fibroxanthoma (AFX). AFX is a rare tumor, but important in the differential diagnosis of other scalp tumors. The routine histological staining allows one to identify a malignant fibrous histiocytoma, while a spindle-cell malignant melanoma can be excluded with immunohistochemical staining. An anaplastic squamous cell carcinoma cannot always be separated with completed certainty from atypical fibroxanthoma. AFX is a low-grade malignant tumor and most cases behave in a benign fashion. After complete excision, we recommend follow-up for a number of years because of the possibility of local recurrence.

Detection of Merkel Cell Polyomavirus DNA in Atypical Fibroxanthoma in Correlation to Clinical Features

“…It occurs in severly sun damaged skin mostly on head and neck. 2,3 Paucity of pathognomonic clinical clues commits definitive diagnosis to histopathology and immunohistology. The tumor is histomorphologically poorly circumscribed, highly cellular, and centered in the dermis.…”