“…We accept that predictions are derived from statistical models, available within learning technologies, known as ML algorithms, which shape current AI. However, reasoning and predicting are two different types of computations, and they cannot be mixed and matched without having a specific software architectural solution (Juric and Ronchieri, 2022), (Juric and Kim, 2017). Therefore, advances in predictions of drug combination based on clinical sideeffects (Huang, et al, 2014) and ML in drug discoveries (Talevi et al, 2020), predictions of synergistic drug combinations (Gayvert et al, 2017), and selective combinations of druggable targets (Tang et al, 2013) are examples of "predictions".…”