Semaphorin 4D levels in heart failure patients: a potential novel biomarker of acute heart failure?

Willner, Nadav; Goldberg, Yair; Schiff, Elad; Vadasz, Zahava

doi:10.1002/ehf2.12275

Cited by 22 publications

(18 citation statements)

References 19 publications

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“…During observation of patients hospitalised due to the exacerbation of HF, there was a significant decrease in Sema4D serum concentration during their hospitalisation after clinical improvement. In the same group of patients, plasma NT-proBNP concentrations were not significantly reduced [49]. For this reason, Sema4D is currently considered as a potential biomarker for acute HF exacerbation, allowing for the diagnosis of acute HF and for the monitoring of the clinical course of HF.…”

Section: Sema4dmentioning

confidence: 93%

“…Sema4D is considered to be a glycoprotein involved mainly in inflammatory processes, although it may be also associated with embryonic development and angiogenesis [49]. When determining serum concentrations of Sema4D in patients with HF, significantly higher concentrations were found than in a healthy control group [49,50]. In addition, a significant increase in the plasma concentration of Sema4D during acute exacerbation of CHF and a rapid reduction in the concentration of this parameter after clinical improvement were observed in the HF group.…”

Section: Sema4dmentioning

confidence: 99%

“…Recently, the interest of researchers has also been aroused by semaphorin 4D (Sema4D), a transmembrane glycoprotein present mainly on platelets and T lymphocytes. Sema4D is considered to be a glycoprotein involved mainly in inflammatory processes, although it may be also associated with embryonic development and angiogenesis [49]. When determining serum concentrations of Sema4D in patients with HF, significantly higher concentrations were found than in a healthy control group [49,50].…”

Section: Sema4dmentioning

confidence: 99%

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Various aspects of inflammation in heart failure

et al. 2019

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Despite significant advances in the prevention and treatment of heart failure (HF), the prognosis in patients who have been hospitalised on at least one occasion due to exacerbation of HF is still poor. Therefore, a better understanding of the underlying pathophysiological mechanisms of HF is crucial in order to achieve better results in the treatment of this clinical syndrome. One of the areas that, for years, has aroused the interest of researchers is the activation of the immune system and the elevated levels of biomarkers of inflammation in patients with both ischaemic and non-ischaemic HF. Additionally, it is intriguing that the level of circulating pro-inflammatory biomarkers correlates with the severity of the disease and prognosis in this group of patients. Unfortunately, clinical trials aimed at assessing interventions to modulate the inflammatory response in HF have been disappointing, and the modulation of the inflammatory response has had either no effect or even a negative effect on the HF prognosis. The article presents a summary of current knowledge on the role of immune system activation and inflammation in the pathogenesis of HF. Understanding the immunological mechanisms pathogenetically associated with left ventricular remodelling and progression of HF may open up new therapeutic possibilities for HF.

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Section: Sema4dmentioning

confidence: 93%

Section: Sema4dmentioning

confidence: 99%

Section: Sema4dmentioning

confidence: 99%

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Various aspects of inflammation in heart failure

et al. 2019

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“…This hypothesis is strengthened by the fact that, as already mentioned, the double KO mice for CD100 and ApoE presented less neovascularization in aortic plaques, what can be also true in human disease ( 63 ). Two independent studies of human cardiovascular diseases have described increased levels of sCD100 in the serum of patients with heart failure compared with healthy controls ( 65 , 66 ), especially in those with diabetes ( 66 ). Soluble CD100 levels showed significant correlation with the levels of creatinine and brain natriuretic peptide, and rapidly decreased after clinical improvement ( 65 ).…”

Section: Cd100 In Atherosclerosismentioning

confidence: 99%

CD100 Effects in Macrophages and Its Roles in Atherosclerosis

Luque

Galuppo

Capelli-Peixoto

et al. 2018

Front. Cardiovasc. Med.

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CD100 or Sema4D is a protein from the semaphorin family with important roles in the vascular, nervous and immune systems. It may be found as a membrane bound dimer or as a soluble molecule originated by proteolytic cleavage. Produced by the majority of hematopoietic cells including B and T lymphocytes, natural killer and myeloid cells, as well as endothelial cells, CD100 exerts its actions by binding to different receptors depending on the cell type and on the organism. Cell-to-cell adhesion, angiogenesis, phagocytosis, T cell priming, and antibody production are examples of the many functions of this molecule. Of note, high CD100 serum levels has been found in inflammatory as well as in infectious diseases, but the roles of the protein in the pathogenesis of these diseases has still to be clarified. Macrophages are highly heterogeneous cells present in almost all tissues, which may change their functions in response to microenvironmental conditions. They are key players in the innate and adaptive immune responses and have decisive roles in sterile conditions but also in several diseases such as atherosclerosis, autoimmunity, tumorigenesis, and antitumor responses, among others. Although it is known that macrophages express CD100 and its receptors, few studies have focused on the role of this semaphorin in this cell type or in macrophage-associated diseases. The aim of this review is to critically revise the available data about CD100 and atherosclerosis, with special emphasis on its roles in macrophages and monocytes. We will also describe the few available data on treatments with anti-CD100 antibodies in different diseases. We hope that this review stimulates future studies on the effects of such an important molecule in a cell type with decisive roles in inflammatory diseases such as atherosclerosis.

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“…The authors showed that persistent hyperlactataemia in 222 acute HF (AHF) patients, defined as lactate level ≥ 2 mmol/L on admission and after 24 h, was associated with more intensive HF treatment, worsening of HF and higher one-year all-cause mortality. Other important CV blood biomarkers that have already been established in AHF include natriuretic peptides, troponins, mid-regional pro-adrenomedullin, interleukin-6, ST2, C-reactive protein, galectin-3, semaphorin 4D, and neutrophil gelatinase-associated lipocalin [13][14][15][16][17][18]. Multimarker strategies have shown even better results in predicting outcomes [19].…”

mentioning

confidence: 99%