2016
DOI: 10.1159/000443645
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Semaphorins and Plexins in Kidney Disease

Abstract: Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological processes in various organs. This review summarizes the role of semaphorins and plexins in renal pathophysiology and their potential use as biomarkers of kidney disease.

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Cited by 14 publications
(12 citation statements)
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References 25 publications
(68 reference statements)
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“…b Each module contained transcripts with similar expression patterns across pre-ischemia, ischemia, and reperfusion conditions. The total number of transcripts in each module is shown response in AKI [34,35]. Integrin and actin signaling pathways linked to Rho signaling related to cytoskeletal remodeling process during cell growth and wound healing were enriched in the reperfusion effect clusters.…”
Section: Som Clustering Analysismentioning
confidence: 99%
“…b Each module contained transcripts with similar expression patterns across pre-ischemia, ischemia, and reperfusion conditions. The total number of transcripts in each module is shown response in AKI [34,35]. Integrin and actin signaling pathways linked to Rho signaling related to cytoskeletal remodeling process during cell growth and wound healing were enriched in the reperfusion effect clusters.…”
Section: Som Clustering Analysismentioning
confidence: 99%
“…SEMA3A has been reported to play important roles in multiple aspects of renal diseases [7]. For example, urinary SEMA3A has been shown to be an early, predictive biomarker of acute kidney injury (AKI) as well as later-onset AKI and progression of AKI [20,21].…”
Section: Discussionmentioning
confidence: 99%
“…Since excess SEMA3A has been reported to be associated with various glomerular diseases [7], we applied the Dox-induced podocytopathy mouse model and examined the change of SEMA3A expression. SEMA3A expression in podocytes was dramatically increased in the Dox group compared to the control group ( Figure 1A).…”
Section: Podocyte Sema3a Expression Is Increased In a Dox-induced Moumentioning
confidence: 99%
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