Earthquake-induced slope instability is one of the most important hazards related to ground shaking, causing damages to the environment and, often, casualties. Therefore, it is important to assess the seismic performance of slopes, especially in the near fault regions, evaluating the permanent displacements induced by seismic loading. This paper applies a probabilistic approach to evaluate the seismic performance of slopes using an updated database of ground motions recorded during the earthquakes occurred in Italy. The main advantage of this approach is that of accounting for the aleatory variability of both ground motions and prediction of seismic-induced displacements of slopes. The results are presented in terms of hazard curves, showing the annual rate of exceedance of permanent slope displacement evaluated using ground motion data provided by a standard probabilistic hazard analysis and a series of semi-empirical relationships linking the permanent displacements of slopes to one or more ground motion parameters. The procedure has been implemented on a regional scale to produce seismic landslide hazard maps for the Irpinia district, in Southern Italy, characterised by a severe seismic hazard. Seismic landslide hazard maps represent a useful tool for practitioners and government agencies for a regional planning to identify and monitor zones that are potentially susceptible to earthquake-induced slope instability, thus requiring further detailed, site-specific studies.