Semi-IPN hydrogels based on Poly(vinyl alcohol) for controlled release studies of chemotherapeutic agent and their Swelling characteristics

Rao, K.S.V. Krishna; Kumar, Arvind; Rao, K. Madhusudhan; Subha, M. C. S.; Lee, Yong‐Ill

doi:10.1007/s00289-008-0925-7

Cited by 30 publications

(12 citation statements)

References 20 publications

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“…The clear supernatant was analyzed for insulin content with a UV–vis spectrophotometer (LAMBDA‐25, PerkinElmer, Wiesbaden, Germany) at 280 nm. All of the experiments were done in triplicate to calculate LE and the encapsulation efficiency by the following formulas:22 …”

Section: Methodsmentioning

confidence: 99%

Formulation of pH‐responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin

Mukhopadhyay

Sarkar

Soam

et al. 2012

J of Applied Polymer Sci

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pH‐sensitive beads were prepared from the interpenetrating polymer networks (IPNs) of carboxymethyl chitosan (CMCTS) and alginate to study their application in oral insulin administration. CMCTS was synthesized from chitosan and was characterized by Fourier transform infrared spectroscopy and wide‐angle X‐ray diffraction. Calcium chloride, a relatively less toxic material, was used to crosslink both the alginate and CMCTS to prepare the IPN beads. The IPN beads were used to encapsulate insulin at different weight ratios. The swelling behavior and insulin release profile in response to simulated gastric and intestinal media of the beads were investigated. The beads observed under scanning electron microscopy were almost spherical, with an average diameter of 780 μm. The bead with about a 54% insulin loading efficiency was observed to contain about 98% encapsulated insulin. The maxima of about 20% insulin retention at acidic pH (1.2) and about 94% insulin release at intestinal pH (7.4) justified the good pH‐responsive nature of these IPN beads. Moreover, the insulin released from the IPN beads was stable and biologically active. © 2012 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013

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Section: Methodsmentioning

confidence: 99%

Formulation of pH‐responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin

Mukhopadhyay

Sarkar

Soam

et al. 2012

J of Applied Polymer Sci

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“…Poly(vinyl alcohol) (PVA) is a nonionic hydrophilic polyhydroxy linear polymer, which have excellent water solubility, nontoxicity, biodegradability, and compatibility. Because PVA is compatible with other polymers, it was considered as a suitable component for the preparation of semi‐IPN hydrogel 23, 24. Also, introducing PVA into hydrogel network can enhance its hydrophilicity, gel strength, and other properties.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization, and swelling behaviors of chitosan‐g‐poly(acrylic acid)/poly(vinyl alcohol) semi‐IPN superabsorbent hydrogels

Liu

Wang

2011

Polymers for Advanced Techs

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A series of granulated semi‐interpenetrating polymer network (semi‐IPN) superabsorbent hydrogels composed of chitosan‐g‐poly(acrylic acid) (CTS‐g‐PAA) and poly(vinyl alcohol) (PVA) were prepared by solution polymerization using ammonium persulfate (APS) as an initiator and N,N′‐methylenebisacrylamide (MBA) as a crosslinker. The effects of reaction conditions such as the concentration of MBA, the weight ratio of AA to CTS, and the content of PVA on water absorbency were investigated. Infrared (IR) spectra and differential scanning calorimetry (DSC) analyses confirmed that AA had been grafted onto CTS backbone, and PVA semi‐interpenetrating into CTS‐g‐PAA networks. SEM analyses indicated that CTS‐g‐PAA/PVA has improved porous surface and PVA was uniformly dispersed in CTS‐g‐PAA network. The semi‐IPN hydrogel containing 10 wt% PVA shows the highest water absorbency of 353 and 53 g g−1 in distilled water and 0.9 wt% NaCl solution, respectively. Swelling behaviors revealed that the introduction of PVA could improve the swelling rate and enhance the pH stability of the superabsorbent hydrogel. Copyright © 2009 John Wiley & Sons, Ltd.

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“…The prepared poly(NIPAAm‐AMPS) hydrogels have shown the thremoresponsive trends during in vitro release of dox when dissolution experiments were performed at 20,25,37, and 50°C. In contrast, NaAlg‐NIPAM microspheres exhibited a release of 5‐Flurouracil of about 90% for 12 h41 and also poly(vinyl alcohol)/poly(acrylamide‐co‐acrylamidoglycolic acid) hydrogels exhibited a release of 5‐Flurouracil of about 100% for 12 h 42. Whereas the poly(NIPAAm‐AMPS) hydrogel formulations of ours show up to 98% cumulative release in 20 h.…”

Section: Resultsmentioning

confidence: 52%

Design and development of temperature sensitive porous poly(NIPAAm‐AMPS) hydrogels for drug release of doxorubicin‐a cancer chemotherapy drug

Varaprasad

Ravindra

Reddy

et al. 2010

J of Applied Polymer Sci

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Temperature sensitive polymer network porous hydrogels were developed with N-Isopropylacrylamide (NIPAAm) and AMPS (2-acrylamido-2-methyl-1-propanesulfonicacid), as well as with sucrose as porogen by crosslinking with hydrophilic crosslinker N,N 1 -methylenebisacrylamide (MBA). The temperature responsive behaviour, the swelling/deswelling kinetics of the hydrogels were investigated. The structural and morphological characterizations of the developed hydrogels were obtained from FTIR spectroscopy and scanning electron microscopy (SEM). The increment in the lower critical solution temperature (LCST) of NIPAAm hydrogels can be done with the help of AMPS and it is confirmed with differential scanning calorimetry (DSC) as well as temperature dependent swelling curves. The model cancer chemotherapy drug Doxorubicin (Dox) was loaded into theses hydrogels and the release studies as well as the released profiles of the drug showed that more than 8-54% of the loaded drug was released in the first half-an-hour at a buffer solution of 7.4 and the rest of the drug was released slowly.

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Semi-IPN hydrogels based on Poly(vinyl alcohol) for controlled release studies of chemotherapeutic agent and their Swelling characteristics

Cited by 30 publications

References 20 publications

Formulation of pH‐responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin

Formulation of pH‐responsive carboxymethyl chitosan and alginate beads for the oral delivery of insulin

Synthesis, characterization, and swelling behaviors of chitosan‐g‐poly(acrylic acid)/poly(vinyl alcohol) semi‐IPN superabsorbent hydrogels

Design and development of temperature sensitive porous poly(NIPAAm‐AMPS) hydrogels for drug release of doxorubicin‐a cancer chemotherapy drug

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