Semiautomated detection of cerebral microbleeds in magnetic resonance images

Barnes, Samuel; Haacke, E. Mark; Ayaz, Muhammad; Boikov, Alexander S.; Kirsch, Wolff M.; Kido, D. K.

doi:10.1016/j.mri.2011.02.028

Cited by 101 publications

(70 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Accurate assessment of microbleeds is known to be hampered by several caveats (Cordonnier et al., 2007). Visual interobserver agreements report median kappa in the range between 0.44 and 0.78 (Cordonnier et al., 2007), and the computational methods existent up‐to‐date have reported degrees of error ranging from 20% to 30% (Barnes et al., 2011; Seghier et al., 2011). Our computational assessment is not exempt of errors.…”

Section: Discussionmentioning

confidence: 99%

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

et al. 2016

View full text Add to dashboard Cite

BackgroundIn structural Magnetic Resonance Imaging (MRI) of patients with a recent small subcortical infarct (RSSI) and small vessel disease (SVD) imaging markers coexist. However, their spatial distribution and prevalence with respect to the hemisphere of the RSSI remain unknown.Materials and MethodsFrom brain MRI in 187 patients with an acute lacunar ischemic stroke clinical syndrome and a relevant diffusion weighted imaging (DWI)‐positive lesion, we semiautomatically extracted the RSSI, microbleeds, lacunes, old cortical infarcts, and white matter hyperintensities (WMH) using optimized thresholding in the relevant sequences, and rated the load of perivascular spaces. We registered all images to an age‐relevant brain template and calculated the probability distribution of all SVD markers mentioned for patients who had the RSSI in each hemisphere separately. We used the Wilcoxon and chi‐squared tests to compare the volumes and frequencies of occurrence, respectively, of the SVD markers between hemispheres throughout the sample.ResultsFifty‐two percent patients (n = 97) had the RSSI in the left hemisphere, 42% (n = 78) in the right, 2.7% (n = 5) in both, and 3.7% (n = 7) in the cerebellum or brainstem. There was no significant difference in RSSI frequency between left and right hemispheres (p = .10) in the sample. The median volume of the RSSI (expressed as a percentage of the total intracranial volume) was 0.05% (IQR = 0.06). There was no difference in median percent volume of the right RSSIs versus left (p = .16). Neither was there a significant interhemispheric difference in the volume of any of the SVD markers regardless of the location of the RSSI and they were equally distributed in both hemispheres.ConclusionAssessment of SVD imaging markers in the contralateral hemisphere could be used as a proxy for the SVD load in the whole brain to avoid contamination by the RSSI of the measurements, especially of WMH.

show abstract

Section: Discussionmentioning

confidence: 99%

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

et al. 2016

View full text Add to dashboard Cite

show abstract

“…This was done to reduce the possibility of detecting vessels with the algorithm, but note that large CMBs would also not be detected and therefore the algorithm is tuned to our current application. This method is also fully automatic and less computationally intensive than the method of Barnes et al, 4 which uses support vector machines to separate CBMs from other hypointensities.…”

Section: Discussionmentioning

confidence: 99%

Hockey Concussion Education Project, Part 1. Susceptibility-weighted imaging study in male and female ice hockey players over a single season

Helmer

Pasternak

Fredman

et al. 2014

JNS

View full text Add to dashboard Cite

Object Concussion, or mild traumatic brain injury (mTBI), is a commonly occurring sports-related injury, especially in contact sports such as hockey. Cerebral microbleeds (CMBs), which are small, hypointense lesions on T2*-weighted images, can result from TBI. The authors use susceptibility-weighted imaging (SWI) to automatically detect small hypointensities that may be subtle signs of chronic and acute damage due to both subconcussive and concussive injury. The goal was to investigate how the burden of these hypointensities change over time, over a playing season, and postconcussion, compared with subjects who did not suffer a medically observed and diagnosed concussion. Methods Images were obtained in 45 university-level adult male and female ice hockey players before and after a single Canadian Interuniversity Sports season. In addition, 11 subjects (5 men and 6 women) underwent imaging at 72 hours, 2 weeks, and 2 months after concussion. To identify subtle changes in brain tissue and potential CMBs, nonvessel clusters of hypointensities on SWI were automatically identified and a hypointensity burden index was calculated for all subjects at the beginning of the season (BOS) and the end of the season (EOS), in addition to postconcussion time points (where applicable). Results A statistically significant increase in the hypointensity burden, relative to the BOS, was observed for male subjects at the 2-week postconcussion time point. A smaller, nonsignificant rise in the burden for all female subjects was also observed within the same time period. The difference in hypointensity burden was also statistically significant for men with concussions between the 2-week time point and the BOS. There were no significant changes in burden for nonconcussed subjects of either sex between the BOS and EOS time points. However, there was a statistically significant difference in the burden between male and female subjects in the nonconcussed group at both the BOS and EOS time points, with males having a higher burden. Conclusions This method extends the utility of SWI from the enhancement and detection of larger (> 5 mm) CMBs that are often observed in more severe TBI, to concussion in which visual detection of injury is difficult. The hypointensity burden metric proposed here shows statistically significant changes over time in the male subjects. A smaller, nonsignificant increase in the burden metric was observed in the female subjects.

show abstract

“…Проводили анализ локализации и количества ЦМК с последующим картированием с помощью рейтинговой анатомической шкалы микрокровоиз-лияний (MARS). Обнаружение трех ЦМК и более расценивали как множественные ЦМК [30,31]. Для оценки лейкоареоза использовали визуальную рей-тинговую шкалу F. Fazekas и соавт.…”

Section: материал и методыunclassified

Cerebral microbleeds in cerebrovascular and neurodegenerative diseases with cognitive impairment

Ta¹,

Os²

2016

Z. nevrol. psikhiatr. im. S.S. Korsakova

View full text Add to dashboard Cite

Semiautomated detection of cerebral microbleeds in magnetic resonance images

Cited by 101 publications

References 21 publications

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

Interhemispheric characterization of small vessel disease imaging markers after subcortical infarct

Hockey Concussion Education Project, Part 1. Susceptibility-weighted imaging study in male and female ice hockey players over a single season

Cerebral microbleeds in cerebrovascular and neurodegenerative diseases with cognitive impairment

Contact Info

Product

Resources

About