Seminal leukocytes are Good Samaritans for spermatozoa

Barraud-Lange, Virginie; Pont, Jean-Christophe; Ziyyat, Ahmed; Pocate, Khaled; Sifer, C.; Cédrin‐Durnerin, Isabelle; Fechtali, Bouchra; Ducot, B.; Wolf, Jean Philippe

doi:10.1016/j.fertnstert.2011.09.035

Cited by 52 publications

(55 citation statements)

References 37 publications

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“…We have already reported that for an infertility patient, moderate leukocytospermia is associated with better sperm parameters, assisted reproduction technologies (ART) outcome, and live birth rate. We also showed that even in the presence of leukocytospermia >10 6 /mL, and contrary to what was expected, leukocytes protect sperm function and are associated with an increased clinical pregnancy rate in ART compared with rates for infertility patients without leukocytospermia (1). We have also showed that moderate leukospermia appears to be physiologic and constitutes a favorable factor for sperm quality and functions (2), in contrast to high leukocytospermia, which is linked to prostatitis.…”

contrasting

confidence: 53%

Seminal leukocytes and clinical outcomes with donor sperm insemination

Barraud-Lange

Pont

Pocate

et al. 2011

Fertility and Sterility

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contrasting

confidence: 53%

Seminal leukocytes and clinical outcomes with donor sperm insemination

Barraud-Lange

Pont

Pocate

et al. 2011

Fertility and Sterility

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“…Therefore, in these patients there could be a condition of SV pseudo-inflammation of the seminal vesicles. Finally, we observed a paradoxical increase in sperm motility associated with moderate leucocytospermia in these patients but also other authors had reported this association in other clinical models (Ziyyat et al, 2008;Barraud-Lange et al, 2011).…”

Section: Discussionsupporting

confidence: 81%

“…In fact it is known that at moderate levels (<10 6 /mL), leucocytospermia is associated with improved sperm fertilization ability and pregnancy outcome (Barraud-Lange et al, 2011), and NO has been shown to modulate in vitro motility, viability and the acrosome reaction of spermatozoa (Revelli et al, 2001). 16.0 ± 6.0 3.07 ± 0.9 13.0 ± 6.0 2.49 ± 0.8 1.0 ± 0.5 1.6 ± 0.8 150.7 ± 30.0 B 13.0 ± 5.0 24.7 ± 4.0 14.0 ± 4.0 3.34 ± 0.5 15.0 ± 4.0 3.70 ± 0.6 1.1 ± 0.5 1.9 ± 0.8 162.2 ± 20.0 After treatment A 13.5 ± 9.0 37.8 ± 18.0* † 25.0 ± 9.0* † 9.45 ± 4.5 * † 14.6 ± 6.5 5.51 ± 2.5 1.5 ± 1.4* † 2.8 ± 1.6* † 206.0 ± 45.0* † B 15.0 ± 9.0 24.0 ± 2.4 16.0 ± 6.0 3.84 ± 0.3 13.0 ± 6.0 3.12 ± 0.1 1.0 ± 0.7 1.7 ± 0.6 166.6 ± 22.2 *p < 0.05 vs. baseline.…”

Section: Discussionmentioning

confidence: 99%

Seminal vesicles and diabetic neuropathy: ultrasound evaluation after prolonged treatment with a selective phosphodiesterase‐5 inhibitor

et al. 2012

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SUMMARYWe have previously reported that infertile patients with diabetes mellitus (DM) have a particular ultrasound features of the seminal vesicles (SV) characterized by higher fundus-to-body ratio and lower pre-and post-ejaculatory difference in body antero-posterior diameter (APD). Based on these premises the aim of the present study was to investigate possible ultrasound SV changes in infertile patients with DM and diabetic neuropathy (DN), after prolonged administration of tadalafil (TAD) (a specific phosphodiesterase-5 inhibitor). To accomplish this, 20 infertile patients with symptomatic DN and erectile dysfunction were selected and arbitrarily divided into two groups which were assigned to: daily administration of 5 mg TAD for 3 months (Group A) (n = 10) and administration of placebo (Group B) (n = 10). All patients underwent to scrotal and prostate-vesicular transrectal ultrasound evaluation and semen analysis (Laboratory Manual for the Examination and Processing of Human Semen, WHO, 2010) before and after treatment. The following SV US parameters were recorded: (i) body APD; (ii) fundus APD; (iii) parietal thickness of the right and left SVs; and (iv) number of polycyclic areas within both SVs. We then calculated the following parameters: (i) fundus/body (F/B) ratio; (ii) difference of the parietal thickness between the right and the left SV and (iii) pre-and post-ejaculatory APD difference. In addition, we also evaluated the SV ejection fraction. Group A patients showed a significant reduction in F/B ratio and higher pre-and post-ejaculatory body SV APD difference compared with baseline or Group B after 3 months. These patients showed also a significant increase in SV ejection fraction and a significant improvement of the total sperm count, progressive motility, seminal levels of fructose, leucocytes and ejaculate volume. In conclusion, these results suggest that infertile DM patients with DN and erectile dysfunction had an improvement of ultrasound features suggestive of diabetic neuropathy after daily treatment with low doses of TAD.

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“…There is an ongoing controversy concerning the biological role of the leukocytes attracted into the semen. Some authors have indicated a lack of any connection between leukocytospermia and diminished semen quality [52][53][54]. However, the vast majority of clinical and experimental in vitro reports have shown a direct association between leukocytospermia and deterioration in semen parameters, in terms of total sperm count [55,56], sperm motility [9,55,[57][58][59][60], sperm morphology [56,59,60], and sperm viability [60].…”

Section: Coli Staphylococcus (S) Aureus Enterococcus (E) Faecalismentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Seminal leukocytes are Good Samaritans for spermatozoa

Cited by 52 publications

References 37 publications

Seminal leukocytes and clinical outcomes with donor sperm insemination

Seminal leukocytes and clinical outcomes with donor sperm insemination

Seminal vesicles and diabetic neuropathy: ultrasound evaluation after prolonged treatment with a selective phosphodiesterase‐5 inhibitor

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

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