Seminal plasma—Immunomodulatory potential in men with normal and abnormal sperm count

Wolff, Michael von; Nowak, Oliver; Pinheiro, Rafael Mota; Strowitzki, T.

doi:10.1016/j.ejogrb.2007.01.009

Cited by 31 publications

(33 citation statements)

References 26 publications

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“…Besides, there are specific amounts of pro-and anti(or tolerance related)-cytokines. 70,71 Moreover, there are differences regarding their source, which calls for differential studies of ejaculate fractions. In that direction, we have studied SP of different categories of human samples grouped as (i) whole ejaculates (control) (ii) samples with lowzinc levels, e.g.…”

Section: Proteomics Of the Ejaculatementioning

confidence: 99%

Seminal Plasma Proteins: What Role Do They Play?

Rodríguez‐Martínez

Kvist

Ernerudh

et al. 2011

American J Rep Immunol

327

273

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Citation Rodríguez‐Martínez H, Kvist U, Ernerudh J, Sanz L, Calvete JJ. Seminal Plasma Proteins: What Role Do They Play? Am J Reprod Immunol 2011; 66 (Suppl. 1): 11–22Problem Semen is a heterogenous and complex cell suspension in a protein‐rich fluid with different functions, some of them well known, others still obscure.Method of study This paper reviews, comparatively, our current knowledge on the growing field of proteomics of the SP and its relevance in relation to the in vivo situation, for the sake of reproductive biology, diagnostics and treatment.Results Ejaculated spermatozoa, primarily bathing in cauda epididymal fluid, are (in vitro) bulky, exposed to most, if not all, secretions from the accessory sexual glands. In vivo, however, not all spermatozoa are necessarily exposed to all secretions from these glands, because sperm cohorts are delivered in differential order and bathe in seminal plasma (SP) with different concentrations of constituents, including peptides and proteins. Proteins are relevant for sperm function and relate to sperm interactions with the various environments along the female genital tract towards the oocyte vestments. Specific peptides and proteins act as signals for the female immune system to modulate sperm rejection or tolerance, perhaps even influencing the relative intrinsic fertility of the male and/or couple by attaining a status of maternal tolerance towards embryo and placental development.Conclusions Proteins of the seminal plasma have an ample panorama of action, and some appear responsible for establishing fertility.

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Section: Proteomics Of the Ejaculatementioning

confidence: 99%

Seminal Plasma Proteins: What Role Do They Play?

Rodríguez‐Martínez

Kvist

Ernerudh

et al. 2011

American J Rep Immunol

327

273

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show abstract

“…Endometrial priming by SP would not be dependent on sperm quality because no differences in cytokine and growth-factor concentrations, nor in the immunomodulatory potential of the SP of men with normal and abnormal sperm counts, were demonstrated [5]. However this issue is still with no closure due to differing findings by others [15,17].…”

Section: Discussionmentioning

confidence: 97%

“…They concluded that the leukocyte and cytokine environment induced in the cervix by seminal fluid appears competent to initiate adaptations in the female immune response that promote fertility. In human in-vitro studies SP was shown stimulating those factors such as leukemia inhibitory factor and interleukin-6 (IL-6) [4,5] that have been described to play an important role in human implantation. Furthermore, SP has been shown to stimulate or inhibit in Ishikawa cells, in which many of those factors that are down-regulated or up-regulated, respectively, in patients undergoing stimulation with gonadotropins for IVF or ICSI [6].…”

Section: Discussionmentioning

confidence: 99%

“…A variety of studies first in animal models such as mice, [1,2] and pigs [3], and then in human in vitro cell culture models [4][5][6] indicate that seminal plasma (SP) reaching the endometrial cavity after intercourse may have an important role in affecting the uterine receptivity. SP contains a variety of factors such as Transforming Growth Factor b, [1,4], prostaglandin E and interleukin-8 [7], that may trigger a cascade of events through pro-inflammatory cytokines synthesis leading to maternal endometrial immunomodulation increasing uterine receptivity.…”

Section: Introductionmentioning

confidence: 99%

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Effect of seminal plasma application to the vaginal vault in in vitro fertilization or intracytoplasmic sperm injection treatment cycles—a double-blind, placebo-controlled, randomized study

Friedler

Ben‐Ami

Gidoni

et al. 2013

J Assist Reprod Genet

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Purpose To study whether intravaginal application of seminal plasma after follicle aspiration has the potential to increase implantation and clinical pregnancy rates after IVF-ET. Methods We conducted a prospective, double-blind, placebocontrolled randomized study of 230 patients undergoing IVF-ET cycles. 500 μL of Fresh seminal plasma from the patient's partner or culture medium (placebo) were injected in the vaginal vault just after follicle aspiration. The main outcome measured was ongoing clinical-pregnancy rate. Results After ET cancellation in ten patients due to lack of fertilization or embryo cleavage, 220 embryo transfers (103 and 117 in the study and control groups) resulted in a clinical pregnancy rate of 36.9 % and 29.1 % for the study and control groups, corresponding to a relative increase of 26.8 %. After an early pregnancy loss of 13.1 % (5/38) and 23.5 % (8/34) in the study and control groups respectively an ongoing pregnancy rate of 32.0 % (33/103) and 22.2 % (26/117) was achieved corresponding to a relative increase of 44.1 %. Multivariate logistic regression analysis adjusted for study group, age, infertility, and cycle characteristics did not demonstrate any parameter that could predict occurrence of clinical pregnancy rates after IVF-ET. Conclusions Patients who underwent SP intravaginal insemination after oocyte pick-up reached higher implantation and clinical pregnancy rates following ET compared to controls, although the difference did not reach statistical significance. More studies and variable methodologies may clarify the potential clinical effect of SP in improving live birth rates after ART.

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“…Im klinischen Kontext ist es von Bedeutung, dass der stimulierende Effekt von Seminalplasma in vitro nicht von der Qualität des Spermiogramms abhängig ist [26].…”

Section: Einfluss Der Zeit Zwischen Ejakulation Und Untersuchung Der unclassified

Semen analysis and seminal plasma

Nitzschke

Strowitzki

Wolff

2009

Gynäkologische Endokrinologie

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LeitthemaWelche Information gibt uns das Spermiogramm über die "männliche" Infertilität? Was bringt die neue IMSI-Technik? Wie können wir mit einfachen Maßnahmen das Befruchtungspotenzial unserer Patienten steigern, und wann empfehlen wir welche Behandlung? Welche Rolle spielt das Seminalplasma bei der Implantation? Sollte man Geschlechtsverkehr um die Zeit des Embryotransfers verbieten? Da diese Fragen dem Reproduktionsmediziner fast täglich in seiner Praxis begegnen, möchten wir im Folgenden die zugrunde liegende Evidenz darstellen und diskutieren. Spermiogramm -GrundlagenDie Anfertigung eines Spermiogramms gehört zu den wichtigsten Routineuntersuchungen im Rahmen der Abklärung von Kinderwunschpatienten. Die Aussagekraft von Spermiogrammen ist jedoch beschränkt, da es sich um eine stark untersucherabhängige und wenig standardisierte Methode handelt. Es ist daher von größter Wichtigkeit, die Samenanalysen möglichst in einem Labor mit viel Erfahrung auf diesem Gebiet durchführen zu lassen. Außerdem sollte sich das Labor möglichst regelmäßig internen und externen Qualitätskontrollen unterziehen. Da die Samenqualität bei einigen Männern stark schwanken kann, sollten immer 2 Spermiogramme in einem Abstand von 1-3 Wochen in dem gleichen Labor angefertigt werden. Bei der Auswertung sollten standardisierte Methoden zur Anwendung kommen, wobei in den meisten Fäl-len nach den von der WHO herausgegebenen Richtlinien untersucht wird [29].

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Seminal plasma—Immunomodulatory potential in men with normal and abnormal sperm count

Cited by 31 publications

References 26 publications

Seminal Plasma Proteins: What Role Do They Play?

Seminal Plasma Proteins: What Role Do They Play?

Effect of seminal plasma application to the vaginal vault in in vitro fertilization or intracytoplasmic sperm injection treatment cycles—a double-blind, placebo-controlled, randomized study

Semen analysis and seminal plasma

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