Seminal Vesicle Gland—Overview

Bromfield, John J.; Ibrahim, Laila A; Rizo, Jason A.

doi:10.1016/b978-0-12-801238-3.64598-1

Cited by 6 publications

(11 citation statements)

References 9 publications

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“…The primary function of the seminal vesicles is to synthesize and secrete a diversity of bioactive factors, including proteins that support gamete function and promote reproductive success ( 1 , 2 , 4 ). To compare our core proteome ( supplemental Table S2 ) to proteins secreted in seminal vesicle fluid, we obtained seminal vesicle fluid proteomic data from Bayram et al.…”

Section: Resultsmentioning

confidence: 99%

“…The combined secretory activity of these tissues gives rise to seminal plasma, a highly viscous fluid containing a complex array of bioactive molecules that support male gamete function after ejaculation and stimulate gene expression and immune response changes in the female reproductive tract ( 2 , 3 ). In the majority of mammalian species, including humans, the androgen-dependent seminal vesicles are the dominant contributor to seminal plasma ( 4 , 5 ). Indeed, elegant experiments to surgically excise the accessory glands have clearly established seminal vesicles as being the most influential tissue that contributes to the rodent ejaculate.…”

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confidence: 99%

“…Indeed, elegant experiments to surgically excise the accessory glands have clearly established seminal vesicles as being the most influential tissue that contributes to the rodent ejaculate. In rodents, seminal vesicle secretions are directly implicated in regulating the conception environment within the female reproductive tract to elicit an immune response that promotes optimal fetal development and supports long-term offspring health ( 1 , 2 , 4 , 6 , 7 , 8 , 9 , 10 , 11 ). In view of the mounting evidence that such roles are conserved among mammals ( 12 , 13 , 14 ), it is likely that the complex molecular signals contained within seminal plasma are of critical importance for promoting reproductive success and maximizing progeny fitness.…”

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Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function

Skerrett‐Byrne

Trigg

Bromfield

et al. 2021

Molecular & Cellular Proteomics

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Seminal vesicles are an integral part of the male reproductive accessory gland system. They produce a complex array of secretions containing bioactive constituents that support gamete function and promote reproductive success, with emerging evidence suggesting these secretions are influenced by our environment. Despite their significance, the biology of seminal vesicles remains poorly defined. Here, we complete the first proteomic assessment of mouse seminal vesicles and assess the impact of the reproductive toxicant acrylamide. Mice were administered acrylamide (25 mg/kg bw/day) or control daily for five consecutive days prior to collecting seminal vesicle tissue. A total of 5013 proteins were identified in the seminal vesicle proteome with bioinformatic analyses identifying cell proliferation, protein synthesis, cellular death, and survival pathways as prominent biological processes. Secreted proteins were among the most abundant, and several proteins are linked with seminal vesicle phenotypes. Analysis of the effect of acrylamide on the seminal vesicle proteome revealed 311 differentially regulated (FC ± 1.5, p ≤ 0.05, 205 up-regulated, 106 downregulated) proteins, orthogonally validated via immunoblotting and immunohistochemistry. Pathways that initiate protein synthesis to promote cellular survival were prominent among the dysregulated pathways, and rapamycin-insensitive companion of mTOR (RICTOR, p = 6.69E-07) was a top-ranked upstream driver. Oxidative stress was implicated as contributing to protein changes, with acrylamide causing an increase in 8-OHdG in seminal vesicle epithelial cells (fivefold increase, p = 0.016) and the surrounding smooth muscle layer (twofold increase, p = 0.043). Additionally, acrylamide treatment caused a reduction in seminal vesicle secretion weight (36% reduction, p = 0.009) and total protein content (25% reduction, p = 0.017). Together these findings support the interpretation that toxicant exposure influences male accessory gland physiology and highlights the need to consider the response of all male reproductive tract tissues when interpreting the impact of environmental stressors on male reproductive function.

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Section: Resultsmentioning

confidence: 99%

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Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function

Skerrett‐Byrne

Trigg

Bromfield

et al. 2021

Molecular & Cellular Proteomics

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“…The secretion of the vesicular gland is responsible for gel plug formation (7, 12). This gland has the highest concentration of the lipid hormone prostaglandin, which is however found in all accessory genital glands (4). The prostaglandins are responsible for the contraction of smooth muscle, and it is thought that they stimulate the contraction of the testicular capsule, seminiferous tubules, epididymis, vas deferens, cervix, and uterine body (6).…”

Section: Introductionmentioning

confidence: 99%

Accessory genital glands in the New Zealand White rabbit: a morphometrical and histological study

Skonieczna

Madej

Będziński

2019

Journal of Veterinary Research

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Introduction: The aim of this research was to provide a detailed description of the morphology, topography, and histometry of rabbit accessory genital glands. Material and Methods: Seven male New Zealand White rabbits, 3–4 months of age and weighing 2.1–3 kg were used for the study. The whole urethra from the urinary bladder to the external urethral orifice accompanied by accessory genital glands was sliced at intervals of 1 mm. The serial sections were prepared with haematoxylin-eosin (H&E) and Movat–Russell modified pentachrome stain. Results: A detailed description of the morphology and morphometry was provided. The topography of the organs was explained on the basis of characteristic cross-sections on histological slides. The inconsistent nomenclature and descriptions of these glands by different authors were also discussed. Conclusion: The morphometric analysis indicated that some of the glands described have similar dimensions in different individuals, while others like paraprostates revealed high diversity in the number of lobes, their size, and their structure. The accessory glands are also good topographic markers which precisely define the segment of the urethra. The terms “proprostate”, “prostate”, and “paraprostates” as the nomenclature of the prostate complex reflect the location of these glands well and indicate their common origin and function.

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“…The latter is accompanied by accessory genital glands, whose size, number and structure differ depending on the animal species. In rabbits, these glands are compound and well developed, comprising the vesicular gland ( glandula vesicularis ), prostate ( prostata ) and bulbourethral gland ( glandula bulbourethralis ) (Bromfield, Ibrahim, & Rizo, 2018; Skonieczna, Madej, & Bȩdziński, 2019; Vásquez & del Sol, 2002, 2009, 2014). Moreover, in these animals, the prostate is very specific because it consists of the proprostate, prostate and two paraprostates (Holtz & Foote, 1978).…”

Section: Introductionmentioning

confidence: 99%

Histological and morphometric evaluation of the urethra and penis in male New Zealand White rabbits

Skonieczna

Madej

Kaczmarek-Pawelska

et al. 2020

Anat Histol Embryol

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This stereudy aimed at performing a histological and morphometric evaluation of the urethra and penis of male rabbits. Seven male New Zealand White rabbits weighing 2.1–3 kg were used in the study. The whole urethra, from the urinary bladder to the external urethral orifice, was dissected from the rabbits, and the tissue was sliced into sections at an interval of 2 mm. The sections were stained with haematoxylin–eosin, Masson–Goldner trichrome stain, Van Gieson's stain and Movat–Russell modified pentachrome stain. A detailed evaluation of the morphology and morphometry was performed. The parameters assessed were the type and height of epithelium, thickness and composition of connective tissue, and thickness and structure of muscularis. The histological structure of the rabbit urethra was found to be similar to humans. However, although the rabbits were found to have the same type of penis as the humans, the internal structure of the corpora cavernosa, the relative thickness of the tunica albuginea and the rudimentary glands of the penis were found to differ in these animals. The results of the present study may be useful in the designing of implants, drug testing or surgical procedures on the physiological and pathological urethra.

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Seminal Vesicle Gland—Overview

Cited by 6 publications

References 9 publications

Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function

Proteomic Dissection of the Impact of Environmental Exposures on Mouse Seminal Vesicle Function

Accessory genital glands in the New Zealand White rabbit: a morphometrical and histological study

Histological and morphometric evaluation of the urethra and penis in male New Zealand White rabbits

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