Seminoma-Like Tumor in the Hyperplastic Thymus Gland

Edland, Robert W.; Levine, Seymour; Serfas, Lee S.; Flair, Robert C.

doi:10.2214/ajr.103.1.25

American Journal of Roentgenology

1968

DOI: 10.2214/ajr.103.1.25

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Seminoma-Like Tumor in the Hyperplastic Thymus Gland

Robert W. Edland¹,

Seymour Levine²,

Lee S. Serfas³

et al.

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1969

1984

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Cited by 11 publications

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Primary thymic seminoma—a neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma

Levine

1973

Cancer

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Epithelial thymoma and thymic seminoma, which are important to distinguish for therapeutic reasons, are often confused histologically. The purpose of this study is to compare the ultrastructural appearances of a primary thymic seminoma, a classical testicular seminoma, and an epithelial thymoma. The thymic seminoma shows many ultrastructural similarities to the classical testicular seminoma in that the tumor cells have bizarre nucleoli, relatively scanty organelles, abundant glycogen, and are rounded or polyhedral with few cell processes. Conversely, there are distinct differences between the thymic seminoma and epithelial thymoma; tumor cells of the latter have many elongated cytoplasmic processes, numerous cytoplasmic filaments and desmosomes, and much less complex nucleoli. Basement membrane material is prominent only in the epithelial thymoma. It is evident that the distinction between thymic seminoma and epithelial thymoma is readily recognizable by electron microscopic studies and terms such as seminomatous or pseudoseminomatous thymoma, which reflect doubt about thymic seminoma as an entity distinct from epithelial thymoma, are misleading.

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Primary thymic seminoma—a neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma

Levine

1973

Cancer

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Mediastinal seminomas

Raghavan

Barrett

1980

Cancer

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A series of malignant seminomas of the mediastinum is presented and compared with previously reported series. The difficulty of conclusively excluding occult primary gonadal disease is noted. Primary mediastinal seminomas are associated with a better prognosis than teratomas of this site, mainly because of their radiosensitivity. A case report of a patient with mediastinal seminoma and two congenital abnormalities (ventricular septal defect and congenital absence of a thoracic hemivertebra) is presented and its relationship to the possible origin of these tumors discussed.

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Mediastinal cysts and tumors

Roux¹,

Kallichurum²,

Shama³

1984

Current Problems in Surgery

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Seminoma-Like Tumor in the Hyperplastic Thymus Gland

Cited by 11 publications

References 1 publication

Primary thymic seminoma—a neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma

Primary thymic seminoma—a neoplasm ultrastructurally similar to testicular seminoma and distinct from epithelial thymoma

Mediastinal seminomas

Mediastinal cysts and tumors

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