Senescence: In search of causality

Orr, William C.

doi:10.1002/(sici)1520-6408(1996)18:2<93::aid-dvg1>3.0.co;2-w

Dev. Genet.

1996

DOI: 10.1002/(sici)1520-6408(1996)18:2<93::aid-dvg1>3.0.co;2-w

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Senescence: In search of causality

William C. Orr

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Cited by 8 publications

(1 citation statement)

References 51 publications

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“…We will call a generic fitness surface multidimensionally epistatic to distinguish it from unidimensionally epistatic fitness functions of a fitness potential. First considered by Bateson (15), Dobzhansky (16), and Muller (17), multidimensional epistasis was studied mostly in the context of speciation (18)(19)(20)(21) and some related phenomena (22)(23)(24). Here, we investigate its impact on the evolution of sex.…”

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confidence: 99%

Multidimensional epistasis and the disadvantage of sex

Kondrashov

2001

Proc. Natl. Acad. Sci. U.S.A.

119

111

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Sex is thought to facilitate accumulation of initially rare beneficial mutations by allowing simultaneous allele replacements at many loci. However, this advantage of sex depends on a restrictive assumption that the fitness of a genotype is determined by fitness potential, a single intermediate variable to which all loci contribute additively, so that new alleles can accumulate in any order. Individual-based simulations of sexual and asexual populations reveal that under generic selection, sex often retards adaptive evolution. When new alleles are beneficial only if they accumulate in a prescribed order, a sexual population may evolve two or more times slower than an asexual population because only asexual reproduction allows some overlap of successive allele replacements. Many other fitness surfaces lead to an even greater disadvantage of sex. Thus, either sex exists in spite of its impact on the rate of adaptive allele replacements, or natural fitness surfaces have rather specific properties, at least at the scale of intrapopulation genetic variability.

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mentioning

confidence: 99%

Multidimensional epistasis and the disadvantage of sex

Kondrashov

2001

Proc. Natl. Acad. Sci. U.S.A.

119

111

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Mitogenic factors accelerate later-age diseases: insulin as a paradigm

Lev-Ran

1998

Mechanisms of Ageing and Development

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Homeostasis and Aging. Slow-Fast Dynamics of Senescence and Death

Novoseltsev

Novoseltseva

Boyko

et al. 2000

IFAC Proceedings Volumes

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Senescence: In search of causality

Cited by 8 publications

References 51 publications

Multidimensional epistasis and the disadvantage of sex

Multidimensional epistasis and the disadvantage of sex

Mitogenic factors accelerate later-age diseases: insulin as a paradigm

Homeostasis and Aging. Slow-Fast Dynamics of Senescence and Death

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