Sennoside A restores colonic barrier function through protecting colon enterocytes from ROS-induced mitochondrial damage in diet-induced obese mice

Functionalized Selenium Nanoparticles Synergizes With Metformin to Treat Breast Cancer Cells Through Regulation of Selenoproteins

“…Excessive production of ROS can cause mitochondrial damage and affect mitochondrial membrane potential ( Ma et al, 2020 ). Therefore, changes in mitochondrial membrane potential of MCF-7 cells were detected at 4, 8 and 12 h. As shown in Figures 5B,C , neither metformin alone nor TW80-SeNPs alone caused any significant change in mitochondrial membrane potential at 4 h, but after treatment with TW80-SeNPs combined with metformin, the JC-1 value increased to 25.79% compared with 0.19% in the control group.…”

Sennoside A is a novel inhibitor targeting caspase-1

“…42 For example, Sen A is commonly used as an irritant laxative in the clinical scenario and potently decreases α-glucoamylase enzymatic activity and further ameliorates type 2 diabetes and obesity. 43,44 Sen A also shows potential to be applied as an anti-tumor drug with a modulatory effect on the slingshot family proteins as well as Wnt and VEGF-signaling pathways that are involved in cancer…”

“…42 For example, Sen A is commonly used as an irritant laxative in the clinical scenario and potently decreases α-glucoamylase enzymatic activity and further ameliorates type 2 diabetes and obesity. 43,44 Sen A also shows potential to be applied as an anti-tumor drug with a modulatory effect on the slingshot family proteins as well as Wnt and VEGF-signaling pathways that are involved in cancer metastasis. 45,46 Moreover, a recent study shed light on Sen A's beneficial properties in liver fibrosis by restraining DNMT1-mediated PTEN hypermethylation in HSC activation and proliferation, and the loss of PTEN contributes to a decreased level of apoptosis.…”

Pharmacology, Toxicology, and Metabolism of Sennoside A, A Medicinal Plant-Derived Natural Compound

“…Once the impairment of intestinal barrier occurs, harmful substances, such as endotoxin and microbiota, may enter the circulation, resulting in chronic low-grade inflammation ( Tilg et al, 2020 ). Some recent studies have suggested that SA may protect the function of intestinal barrier ( Ma et al, 2020a ; Wei et al, 2020 ). Ma et al reported that SA (30 mg/kg) could protect colon enterocytes from ROS toxicity and restore colonic barrier function, thereby improving insulin sensitivity induced low-grade chronic inflammation ( Ma et al, 2020a ).…”

“…Some recent studies have suggested that SA may protect the function of intestinal barrier ( Ma et al, 2020a ; Wei et al, 2020 ). Ma et al reported that SA (30 mg/kg) could protect colon enterocytes from ROS toxicity and restore colonic barrier function, thereby improving insulin sensitivity induced low-grade chronic inflammation ( Ma et al, 2020a ). Similarly, Wei et al suggested that SA (25, 50 mg/kg) decreased tissue inflammation by upregulating ZO-1 and occludin protein levels and protecting intestinal barrier function ( Wei et al, 2020 ).…”