Sensing and bioimaging of lead ions in intracellular cancer cells and biomedical media using amine-functionalized silicon quantum dots fluorescent probe

Concanavalin A-conjugated gold nanoparticle/silica quantum dot (AuNPs/SiQDs-Con A)-based platform as a fluorescent nanoprobe for the bioimaging of glycan-positive cancer cells

“…However, the surface charges of the AuNPs, Si NH 2 QDs, and Con A are À39.5 mV, À12.6 mV, and À14.2 mV, respectively; thus, the change of the surface charge of the cit-AuNPs-MPA/Si-NH 2 QDs/Con A NPs to a positive value proves their efficient functionalization with Con A. [29][30][31] These results demonstrated the proper attachment of Con A on the surface of the AuNPs.…”

“…Although the emission wavelength was largely affected by the structure of the cit-AuNPs-MPA/Si-NH 2 QDs/Con A NPs, the excitation peak changed by only 5 nm, which is another reason for the n–π* transition. 31,35…”

“…Although the emission wavelength was largely affected by the structure of the cit-AuNPs-MPA/Si-NH 2 QDs/Con A NPs, the excitation peak changed by only 5 nm, which is another reason for the n-p* transition. 31,35 The inuence of the excitation wavelength of cit-AuNPs-MPA/Si-NH 2 QDs/Con A was another factor affecting the emission of the NPs, which is demonstrated in Fig. S13.…”

Bio-Conjugated Quantum Dots for Cancer Research: Detection and Imaging

“…QDs-based signal probes are of great interest and have been tested in numerous biotechnological applications. Some of the early and most successful uses of QDs have been in immunofluorescence labeling of fixed cells and tissues (15,16), immuno-staining of membrane proteins (17,18), microtubules (19), nuclear antigens (20,21), and fluorescence in situ hybridization of chromosomes or combed DNA (22, 23) (Figure 3).…”

Pyridine Scaffolds, Phenols and Derivatives of Azo Moiety: Current Therapeutic Perspectives

“…World health organization (WHO) insists on taking precautions to limit the toxic effects of heavy metals around the globe. In this regard, various strategies have been reported for the detection of metal ions, from which fluorescence–based sensors have gained much attention due to their high sensitivity, selectivity, simple protocols and non-destructive nature [ 71 , 72 , 73 ]. One of the most practiced fluorescence-based sensing is chemo-sensing, which employs a small molecule that signals the presence of an analyte by binding to it and in result the variation in the molecular properties is recorded.…”