Biological flow receptors show astonishing performance and are used as models for the design of novel flow sensors. However, the functional importance of interfacial microstructures is seldom discussed in previous review papers. Herein, this review summarises the underlying biomechanical principles in the biological flow receptors and describes the recent progress in bio-inspired flow sensors, in which the underlying sensing-enhancement mechanisms are emphasised. 2.1.2 Pit organ: In non-teleost fishes and amphibians, some SNs that sit in pits or grooves on the skin are referred to be called as 'pit organs,' and linear series of such neuromasts are viewed as 'pit lines' [22-24]. Northcutt and Bleckmann [25] investigated that the 'pit organs' in the axolotl (Ambystoma mexicanum) are similar to other Biosurface and Biotribology