Sensitive and Rapid Quantification of Felodipine by High-performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) and Its Pharmacokinetics in Healthy Chinese Volunteers1

Li, Y; Yin, Yongguang; Sun, Zheng; Li, X; Hu, Lianghai; Li, P; Zhong, Dafang

doi:10.1016/s1005-9040(06)60146-3

Cited by 4 publications

(2 citation statements)

References 12 publications

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“…With the increase of PLA-fiber (Fig. 2b, 2c, 2d, 2e) the hydroxyapatite crystal diffraction peaks gradually evident, however, the peaks still express broad, it suggested that low crystallinity of HA produced in the f (PLA) -HA/CS composites, this can be concerned with the laminated hybridization principle [9]. There is no fiber mixed in Fig.…”

Section: Resultsmentioning

confidence: 92%

Preparation and Characterization of Polylactic Acid Fiber Enhanced Hydroxyapatite/Chitosan Composites

Yin

Yang

2011

AMR

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A novel hydroxyapatite/chitosan composite plate enhanced by polylactic acid fiber is prepared via in–situ hybridization in the semipermeable mold. The influence factors of the composites are evaluated by orthogonal test; FT–IR, XRD and SEM are also used to determine the relevance between the composition and performance. Analyses show that: hydroxyapatite with weak crystalline state is generated in the composites; there is hydrogen bonding associating existing in the complex system; preferable interface junction is created between the fiber and hydroxyapatite /chitosan matrix, which is able to play benign potentiation to the mechanical strength. Orthogonal test finds that the pecking order of the influencing factors to physical properties is: fiber content > fiber length > hydroxyapatite content. HA/CS composite plate enhanced by PLA–fiber can get a significantly increase on flexural strength and bending modulus, therefore, it will be a kind of potential orthopaedic materials which possesses the ability of completely degraded.

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Section: Resultsmentioning

confidence: 92%

Preparation and Characterization of Polylactic Acid Fiber Enhanced Hydroxyapatite/Chitosan Composites

Yin

Yang

2011

AMR

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“…[2] In the literature survey very few analytical methods have been reported for the determination of FLD which include spectroscopic techniques, [3] gas chromatography-mass spectrometry (MS), [4] high-performance liquid chromatography (HPLC) biological fluids [5,6] and HPLC, [7][8][9][10][11][12] micellar HPLC, [13] and HPLC with amperometric detection [14] and also in the biological fluids such as rat plasma and other dosage forms [15][16][17][18][19] and LC-tandem MS/MS in dog and human plasma. [20][21][22][23][24] In the present study, the authors have proposed new stability indicating LC method for the determination of FLD in pharmaceutical dosage forms.…”

Section: F Elodipine (Fld) [Figurementioning

confidence: 99%

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Kallepalli¹

2018

AJP

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Introduction: Felodipine is used for the treatment of hypertension. In the present study a new stability-indicating RP-HPLC method has been established for the determination of Felodipine.in pharmaceutical dosage forms and the method was validated. Material and Methods: Shimadzu Model CBM-20A/20 Alite, UFLC system was used for the assay of Felodipine using a mixture of phosphate buffer (pH 7.0) and acetonitrile (20:80, v/v) as mobile phase with a flow rate of 1.2 ml/min (UV detection at 234 nm). Forced degradation studies were performed by exposing Felodipine to different stress conditions and the method was validated as per ICH guidelines. Results and Discussion: Felodipine is found to be more sensitive towards oxidative degradation. Conclusion: The proposed method is simple and economical and can be used for the determination of Felodipine in pharmaceutical formulations.

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Cerium(iv)-Based Chemiluminescence of Felodipine Sensitized by Rhodamine 6g

Fang

Bian

2010

Instrumentation Science & Technology

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Sensitive and Rapid Quantification of Felodipine by High-performance Liquid Chromatography-tandem Mass Spectrometry (HPLC-MS/MS) and Its Pharmacokinetics in Healthy Chinese Volunteers1

Cited by 4 publications

References 12 publications

Preparation and Characterization of Polylactic Acid Fiber Enhanced Hydroxyapatite/Chitosan Composites

Preparation and Characterization of Polylactic Acid Fiber Enhanced Hydroxyapatite/Chitosan Composites

Untitled

Cerium(iv)-Based Chemiluminescence of Felodipine Sensitized by Rhodamine 6g

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