Sensitive detection of glyoxal by cluster-mediated CH2Br2+ chemical ionization time-of-flight mass spectrometry

Wan, Ningbo; Jiang, Jichun; Wang, Heng-Ding; Chen, Ping; Fan, Hongjun; Wang, Weiguo; Lee, Hua; Li, Haiyang

doi:10.1016/j.aca.2022.339612

Cited by 6 publications

(3 citation statements)

References 40 publications

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“…In addition to the photon flux, the photoionization cross sections and ionization energies of analytes also influence the detection efficiency of SPI-MS. 41,42 To overcome this problem, dopant-assisted photoionization has been developed as a powerful method to ionize analytes via charge transfer reactions. 20,43,44 Photoinduced associative ionization (PAI) is a newer ionization pathway discovered in recent years that is intrinsically different from dopant-assisted photoionization. 45−47 During PAI, gaseous CH 2 Cl 2 initially absorbs VUV light and generates excited state CH 2 Cl 2 *, and then CH 2 Cl 2 * interacts with H 2 O and the analyte through an associative reaction to convert a proton from neutral H 2 O to the analyte.…”

Section: ■ Introductionmentioning

confidence: 99%

“…However, fabricating these laboratory-made VUV lamps requires a certain technical foundation and is challenging. In addition to the photon flux, the photoionization cross sections and ionization energies of analytes also influence the detection efficiency of SPI-MS. , To overcome this problem, dopant-assisted photoionization has been developed as a powerful method to ionize analytes via charge transfer reactions. ,, …”

Section: Introductionmentioning

confidence: 99%

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A Simple High-Flux Switchable VUV Lamp Based on an Electrodeless Fluorescent Lamp for SPI/PAI Mass Spectrometry

et al. 2023

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Single-photon ionization (SPI) is a unique soft ionization technique for organic analysis. A convenient high-flux vacuum ultraviolet (VUV) light source is a key precondition for wide application of SPI techniques. In this study, we present a novel VUV lamp by simply modifying an ordinary electrodeless fluorescent lamp. By replacing the glass bulb with a stainless steel bulb and introducing 5% Kr/He (v/v) as the excitation gas, an excellent VUV photon flux over 4.0 × 1014 photons s–1 was obtained. Due to its rapid glow characteristics, the VUV lamp can be switched on and off instantly as required by detection, ensuring the stability and service life of the lamp. To demonstrate the performance of the new lamp, the switchable VUV lamp was coupled with an SPI-mass spectrometer, which could be changed to photoinduced associative ionization (PAI) mode by doping gaseous CH2Cl2 to initiate an associative ionization reaction. Two types of volatile organic compounds sensitive to SPI and PAI, typically benzene series and oxygenated organics, respectively, were selected as samples. The instrument exhibited a high detection sensitivity for the tested compounds. With a measurement time of 11 s, the 3σ limits of detection ranged from 0.33 to 0.75 pptv in SPI mode and from 0.03 to 0.12 pptv in PAI mode. This study provides an extremely simple method to assemble a VUV lamp with many merits, e.g., portability, robustness, durability, low cost, and high flux. The VUV lamp may contribute to the development of SPI-related highly sensitive detection technologies.

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Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A Simple High-Flux Switchable VUV Lamp Based on an Electrodeless Fluorescent Lamp for SPI/PAI Mass Spectrometry

et al. 2023

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“…Figure 2a To further illustrate the matrix elimination effect of the TRFTV sampling strategy, a continuous vaporization (CV) sampling method was used for comparison. The device for CV sampling was clearly displayed in previous work 42 and described briefly in Supporting Information S1. For the CV strategy, the Chinese liquor sample with the same EC content was injected into a heated glass vial continuously at an injection rate of 10 μL/min by a syringe pump.…”

Section: ■ Introductionmentioning

confidence: 99%

Rapid Determination of Ethyl Carbamate in Chinese Liquor via a Direct Injection Mass Spectrometry with Time-Resolved Flash-Thermal-Vaporization and Acetone-Assisted High-Pressure Photoionization Strategy

Cao

Yang²,

Xie

et al. 2023

Anal. Chem.

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Ethyl carbamate (EC), a carcinogenic compound, is naturally produced in fermented foods and alcoholic beverages. Rapid and accurate measurement of EC is necessary and important for quality control and safety evaluation of Chinese liquor, a traditionally distilled spirit with the highest consumption in China, but it remains a great challenge. In this work, a direct injection mass spectrometry (DIMS) with time-resolved flash-thermal-vaporization (TRFTV) and acetone-assisted high-pressure photoionization (HPPI) strategy has been developed. EC was rapidly separated from the main matrix components, ethyl acetate (EA) and ethanol, by the TRFTV sampling strategy due to the retention time difference of these three compounds with large boiling point differences on the inner wall of a poly(tetrafluoroethylene) (PTFE) tube. Therefore, the matrix effect of EA and ethanol was effectively eliminated. The acetone-assisted HPPI source was developed for efficient ionization of EC through a photoionization-induced proton transfer reaction between EC molecules and protonated acetone ions. The accurate quantitative analysis of EC in liquor was achieved by introducing an internal standard method (ISM) using deuterated EC (d 5-EC). As a result, the limit of detection (LOD) for EC was 8.88 μg/L with the analysis time of only 2 min, and the recoveries ranged from 92.3 to 113.1%. Finally, the prominent capability of the developed system was demonstrated by rapid determination of trace EC in Chinese liquors with different flavor types, exhibiting wide potential applications in online quality control and safety evaluation of not only Chinese liquors but also other liquor and alcoholic beverages.

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A new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry for highly sensitive detection of trace exhaled ethylene

Zhang,

Hua,

Fan

et al. 2024

Analytica Chimica Acta

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Sensitive detection of glyoxal by cluster-mediated CH2Br2+ chemical ionization time-of-flight mass spectrometry

Cited by 6 publications

References 40 publications

A Simple High-Flux Switchable VUV Lamp Based on an Electrodeless Fluorescent Lamp for SPI/PAI Mass Spectrometry

A Simple High-Flux Switchable VUV Lamp Based on an Electrodeless Fluorescent Lamp for SPI/PAI Mass Spectrometry

Rapid Determination of Ethyl Carbamate in Chinese Liquor via a Direct Injection Mass Spectrometry with Time-Resolved Flash-Thermal-Vaporization and Acetone-Assisted High-Pressure Photoionization Strategy

A new photoionization-induced substitution reaction chemical ionization time-of-flight mass spectrometry for highly sensitive detection of trace exhaled ethylene

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