Sensitive determination of endogenous hexanal and heptanal in urine by hollow-fiber liquid-phase microextraction prior to capillary electrophoresis with amperometric detection

Chen, Fang; Wang, Chunqiu; Zhang, Mei-Jiang; Zhang, Xiaoli; Liu, Yan; Ye, Jiannong; Chu, Qingcui

doi:10.1016/j.talanta.2013.10.052

Cited by 36 publications

(12 citation statements)

References 34 publications

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“…Weiz et al. studied serum glycoproteins as a source of potential biomarkers for epithelial ovarian cancer by analyzing isolated spots from 2DE by labeling them with a fluorescent dye then subjecting the sample to further analysis by CE‐LIF. The work reports that core‐fucosylated N‐glycans on α1‐acid glycoprotein as well as higher amounts of Lewis(X) motif on haptoglobin, α1‐antitrypsin, and α1‐antichymotrypsin are all good potential biomarkers for ovarian cancer.…”

Section: Applications In Different Clinical Fieldsmentioning

confidence: 99%

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Phillips

2017

Electrophoresis

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Recent advances in CE and microchip-CE in clinical applications: 2014 to mid-2017CE and microchip CE (ME) are powerful tools for the analysis of a number of different analytes and have been applied to a variety of clinical fields and human samples. This review will present an overview of the most recent applications of these techniques to different areas of clinical medicine during the period of 2014 to mid-2017. CE and ME have been applied to clinical chemistry, drug detection and monitoring, hematology, infectious diseases, oncology, endocrinology, neonatology, nephrology, and genetic screening. Samples examined range from serum, plasma, and urine to lest utilized materials such as tears, cerebral spinal fluid, sweat, saliva, condensed breath, single cells, and biopsy tissue. Examples of clinical applications will be given along with the various detection systems employed.

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Section: Applications In Different Clinical Fieldsmentioning

confidence: 99%

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Phillips

2017

Electrophoresis

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“…used the same electroactive derivatisation to determine potential cancer biomarkers (i.e. hexanal and heptanal) from urine . Sensitive determination at low micromolar levels was obtained.…”

Section: Derivatisation For Detectionmentioning

confidence: 99%

“…Derivatisation in CE is used to improve or enable detection by LIF, UV, chemiluminescence (CL), electrochemiluminescence (ECL), amperometric detection (AD), MS or contactless conductivity detection (C4D). During this review period, there were papers 18 on LIF (and LIF combined with other detectors) [, , ], 18 on UV (and UV combined with other detectors) [, , ], two on CL , one on ECL , two on AD , three on MS (and MS combined with other detectors) and two on C4D .…”

Section: Derivatisation For Detectionmentioning

confidence: 99%

Derivatisation for separation and detection in capillary electrophoresis (2012–2015)

Wuethrich

Quirino

2015

Electrophoresis

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Derivatisation is a well-established and mature form of sample preparation for CE. The modification of the analyte can cause superior analysis characteristics such as better sensitivity and selectivity, however, derivatisation of the analyte introduces an additional step into the analytical workflow. This review covers articles from January 2012 to January 2015 on derivatisation in CE. The main sections are on the derivatisation modes (i.e. pre-capillary, in-line, in-capillary and post-capillary), separation and detection modes (i.e. LIF and others). LIF is discussed in more detail since this detection mode was most prevalent. A table of the common labelling agents and wavelengths for excitation and emission and the common derivatisation reactions are included. In addition, a comprehensive table which summarises all research articles is provided. This review is suitable for analytical chemists as a guide for 'how to get started' with derivatisation for separation and detection in CE.

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“…But so far only a few literatures focused on the determination of LMMAs in water samples by CE coupled with UV or LIF detection , and 2,4‐dinitrophenylhydrazine is still the most popular derivative reagent for CE analyses of LMMAs. In our previous studies, an electroactive compound 2‐thiobarbituric acid (TBA) was selected as an ideal derivative reagent for electrochemical detection, and several typical aldehydes in urine , food or commodity samples have been sensitively determined by CE with amperometric detection (CE–AD).…”

Section: Introductionmentioning

confidence: 99%

“…Besides, sample preparation procedure is necessary to improve the sensitivity of the method due to the low levels of aldehydes and the complexity of sample matrices. Several studies have dealt with the use of SPME and LPME techniques as an alternative to the classical LLE and SPE approaches . It is worth mentioning that hollow‐fiber liquid‐phase microextraction (HF‐LPME) gained popular attention in the field of sample preparation because of its good sample purification and interference avoiding abilities as well as low organic solvent consumption, and that the extract of three‐phase dynamic HF‐LPME approach is aqueous solution, which has good compatibility with the running buffer of CE.…”

Section: Introductionmentioning

confidence: 99%

Hollow-fiber liquid-phase microextraction coupled with miniature capillary electrophoresis for the trace analysis of four aliphatic aldehydes in water samples

Zheng

et al. 2015

J. Sep. Science

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An environmentally friendly method for the trace analysis of four aliphatic aldehydes as water disinfection byproducts has been developed based on hollow-fiber liquid-phase microextraction followed by miniature capillary electrophoresis with amperometric detection. After derivatization with 2-thiobarbituric acid, four aliphatic aldehydes (formaldehyde, acetaldehyde, propylaldehyde, and butyraldehyde) became detectable by the amperometric detector. Under the optimum conditions, four aliphatic aldehydes can be well separated from the coexisting interferents as well as their homologs (pentanal, glyoxal, and methyl-glyoxal), and the limits of detection (S/N = 3) could reach sub-nanogram-per-milliliter level based on hollow-fiber liquid-phase microextraction. The proposed method has been applied for the analyses of above four aliphatic aldehydes in different water samples such as drinking water, tap water, and river water, and the average recoveries were in the range of 90-113%, providing an alternative to conventional and microchip capillary electrophoresis approaches.

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Sensitive determination of endogenous hexanal and heptanal in urine by hollow-fiber liquid-phase microextraction prior to capillary electrophoresis with amperometric detection

Cited by 36 publications

References 34 publications

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Recent advances in CE and microchip‐CE in clinical applications: 2014 to mid‐2017

Derivatisation for separation and detection in capillary electrophoresis (2012–2015)

Hollow-fiber liquid-phase microextraction coupled with miniature capillary electrophoresis for the trace analysis of four aliphatic aldehydes in water samples

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