Sensitive determination of ketoprofen using flow injection with chemiluminescence detection

Zhuang, Yafeng; Song, Hengli

doi:10.1016/j.jpba.2007.03.014

Cited by 26 publications

(15 citation statements)

References 26 publications

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“…ing action of these non-fluorescent compounds are different from each other, the sensitizing effect of CAPS is attribute to the presence of the cyclohexyl ring [31,34]. On the one hand the molecule of tramadol hydrochloride (Figure 1) contains a cyclohexyl ring, on the other hand the CL spectrum of KMnO 4 -Na 2 SO 3 -H 2 SO 4 system in the presence and absence of tramadol hydrochloride showed similar emission profile extending from 450 to 600 nm (Figure 8), which was measured by means of a series of interference filters.…”

Section: Determination Of Tramadol Hydrochloride In Pharmaceutical Prmentioning

confidence: 99%

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

Yao¹,

Zhang²,

Li³

2011

AJAC

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In this paper, a novel chemiluminescence (CL) method for the determination of tramadol has been developed by combining the flow injection technique and its sensitizing effect on the weak CL reaction between sulfite and acidic KMnO 4 . A mechanism for the CL reaction has been proposed on the basis of fluorescent and CL spectra. Under the optimized conditions, the proposed method allows the measurement of tramadol hydrochloride over the range of 0.04 -4 g/mLwith a correlation coefficient of 0.9995 (n = 8) and a detection limit of 0.01 g/mL (3σ), and the relative standard deviation for 2.0 g/mL tramadol (n = 11) is 2.1%. The utility of this method was demonstrated by determining tramadol hydrochloride in tablets and injections.

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Section: Determination Of Tramadol Hydrochloride In Pharmaceutical Prmentioning

confidence: 99%

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

Yao¹,

Zhang²,

Li³

2011

AJAC

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“…Some techniques includes capillary zone electrophoresis 4 , UV-spectrophotometry [5][6][7][8] , highperformance liquid chromatography [9][10][11][12] , flow injection technique with hemiluminiscence 13,14 , flow injection with UV-detection 15 , polarography 16 ODS of 10cm X 4.6 mm column, (5μm particle size). The mobile phase, degassed under vacuum in an ultrasonic bath, consists of 0.01 M sodium dihydrogen phosphate (adjusted to pH 6.5 with orthophosphoric acid), methanol and acetonitrile, 4:4:3 (v/v), respectively.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2016

IJPSR

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A simple and accurate Reverse Phase High Performance Liquid Chromatography (RP-HPLC) method has been developed for the estimation of ketoprofen in vitro samples and in vivo samples from bulk drug and from administered transdermal dosage form, using Spherosorb S5 ODS of 10cm X 4.6 mm column, (5μm particle size). Mobile phase for in vitro sample analysis and in vivo plasma samples consists of 0.01 M sodium dihydrogen phosphate (pH adjusted to 6.5 with ortho phosphoric acid), methanol, and acetonitrile, 4:3:3 (v/v) respectively. Isocratic elution technique was followed. The flow rate was 0.5ml/min and the detection was monitored out by UV detector at 265nm. The retention time for ketoprofen was found to be 2.982 in in vitro sample and 3.025 min in in vivo sample. Naproxen was used as internal standard for in vivo sample analysis. The proposed method has permitted the quantification of ketoprofen over linearity in the range of 100-1000 ng/ml.

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“…There are some disadvantages, such as several time‐consuming manipulations, special training, or requirement of comparatively expensive equipment and they are not readily amenable to be cost‐effective or to miniaturized instrumentation . The use of flow‐injection chemiluminescence for the analysis of pharmaceuticals has become increasingly popular in recent years, which is known to be a useful analytical technique because of its low detection limit, wide linear dynamic range, and relatively low‐cost instrumentation …”

Section: Introductionmentioning

confidence: 99%

A novel flow‐injection chemiluminescence method for determination of andrographolide in andrographis tablets

Jiang

Zhang

et al. 2012

Drug Testing and Analysis

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A novel method for determination of andrographolide using flow-injection chemiluminescence (FI-CL) analysis is described in this paper. The chemiluminescence intensity of the solution was enhanced proportionally while the concentration of andrographolide increased. Under the selected experimental conditions, the calibration curve of andrographolide was linear within the range of 0.2 to 35.0 µg mL(-1) with a linear equation of ΔI = 23.391x (µg mL(-1)) + 34.191, R(2) = 0.9965. The detection limit (3σ) was 7.42 × 10(-2) µg mL(-1). At the case of continuous determination of andrographolide, the relative standard deviation (RSD, n =11) was less than 1.82%. The method has been successfully applied to the determination of andrographis tablets with satisfactory results.

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Sensitive determination of ketoprofen using flow injection with chemiluminescence detection

Cited by 26 publications

References 26 publications

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

Flow Injection Determination of Tramadol Based on Its Sensitizing Effect on the Chemiluminescent Reaction of Permanganate-Sulfite

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A novel flow‐injection chemiluminescence method for determination of andrographolide in andrographis tablets

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