Sensitive Fluorescent Sensor for Hydrogen Sulfide in Rat Brain Microdialysis via CsPbBr₃ Quantum Dots

Abstract

The instability and insolubility of perovskite quantum dots in aqueous solution prohibit applications in polar solvents. As a highly toxic gas pollutant and also an endogenous gaseous signaling molecule existing in a variety of physiological processes, hydrogen sulfide (H2S), with high selectivity and high specificity, detection is of great significance. In this study, a simple device has been designed to separate H2S from aqueous solution and CsPbBr3 quantum dots (CsPbBr3 QDs) have been used as the detection probe to develop a novel fluorescent sensor for rapid H2S detection. The addition of hydrogen sulfide to the phosphoric acid solution results in the escape of H2S from the aqueous sample and hence it passing into the n-hexane solution containing CsPbBr3 QDs, resulting in the quenching of the fluorescence of CsPbBr3 QDs. The fluorescence intensity of the system has a linear relationship with the concentration of H2S in the range of 0–100 μM with the detection limit of 0.18 μM. The proposed system has been applied to detection of H2S in rat brain microdialysate with satisfying results. The potential mechanism regarding the quenching of fluorescence from CsPbBr3 QDs by H2S has been studied as well.

Ultrathin 2D NbWO6 Perovskite Semiconductor Based Gas Sensors with Ultrahigh Selectivity under Low Working Temperature

“…Detection of H 2 S with a LOD at ppm level is very meaningful because typical environmental standard sets the threshold of H 2 S at 0.1–100 ppm. [ 2 ] In addition, the sensing response is enhanced with the increase of H 2 S concentration (Figure 3F). The NbWO 6 ‐nanosheets‐based sensor displays a response and recovery time of 6 and 30 s, respectively, to 50 ppm H 2 S (Figure 3G), indicating a rapid response–recovery speed of the gas sensor.…”

“…Hydrogen sulfide (H 2 S) is a kind of toxic, malodorous, flammable, highly corrosive, and volatile gas that mainly produced by natural coal manufacturing, [1] oil refining, and food processing industries, [2] posing a serious threat to atmospheric contamination and respiratory disease. [3] H 2 S is also used as an important endogenous gas signaling molecule for physiological regulatory in the cardiovascular, endocrine, and gastrointestinal, etc.…”

Colorimetric Sensing of Benzoyl Peroxide Based on the Emission Wavelength-Shift of CsPbBr3 Perovskite Nanocrystals

“…CsPbBr 3 NCs are one of many superficial defects, and fluorescence sensing methods can be established by passivation of these superficial defects. For example, O 2 can significantly enhance the fluorescence of CsPbBr 3 nanosheets, CsPbBr 3 nanowires, and CsPbBr 3 single crystals due to their many surface defect states [20] which can be used for O 2 sensing. Common energy transfer in fluorescence sensing also is applied by using CsPbBr 3 NCs.…”

“…Additionally, a sensing approach for methylamine (MA) gas has been set up with the fluorescence turnon and wavelength shift in the formation of MAPbBr 3 NPs in hollow SiO 2 nanospheres triggered by the reaction between MA gas and HPbBr 3 /PbBr 2 @SiO 2 nanospheres [24]. In 2019, Lin et al designed a simple device for the separation and sensing of H 2 S with high sensitivity and selectivity using CsPbBr 3 NCs [20]. The fluorescence intensity was linearly related to H 2 S concentration (in the range of 0~100 µM), and the detection limit was 0.18 µM.…”

Anomalous NH3Induced Resistance Enhancement in Halide Perovskite MAPbI3 Film and Gas Sensing Performance

“…Besides the halogen and halide gases, the halide perovskites are also sensitive to several other gases, such as SO 2 , 31 H 2 S, 32 NO 2 , 33 O 2 , 34 O 3 , 35 . Since the above gases are difficult to obtain, we have not studied the sensing behaviors toward these gases.…”