Sensitive liquid chromatography–tandem mass spectrometry method for the determination of pantoprazole sodium in human urine

Bhaskar, B.L.; Kumar, Uttom; Basavaiah, K.

doi:10.1016/j.arabjc.2010.06.033

Cited by 15 publications

(7 citation statements)

References 3 publications

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“…It was also determined spectrophotometrically with OMP through complex formation with iron (III) in an aqueous ethanol medium [ 14 ]. LC-MS/MS was applied for the determination of PNT using LNZ as an internal standard (IS), either in human plasma [ 15 ] or in human urine [ 16 ]. The same technique was also applied for the sensitive monitoring of the studied drug in a bioequivalence study [ 17 ].…”

Section: Introductionmentioning

confidence: 99%

Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

2021

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Monitoring and quantification of active pharmaceutical ingredients (APIs) in the environment constitute important and challenging tasks, as they are directly associated with human health. Three commonly used proton pump inhibitors (PPIs), namely, omeprazole sodium (OMP), pantoprazole sodium (PNT), and lansoprazole sodium (LNZ) are well separated and quantified using ultra-performance liquid chromatography (UPLC) in pharmaceutical industrial wastewater. The separation of the studied drugs was performed on a stationary phase with a WatersTM column (100 × 2.1 mm, 1.7 µm). The mobile phase was composed of methanol:0.05 M potassium dihydrogen phosphate buffer (adjusted to pH 7.5 using NaOH) (50:50, v/v). The elution process was done in gradient mode by changing the relative proportions of the mobile phase components with time to get an optimum separation pattern. The flow rate of the developing system was adjusted to 0.8 mL/minute. Detection of the separated drugs was performed at 230 nm. The studied drugs were quantified in the concentration range of 10–200 ng/mL for all drugs. The cited method was fully validated according to the international conference on harmonization (ICH-Q2B) guidelines, then it was applied successfully for quantification of the studied PPIs in real wastewater samples after their solid phase extraction (SPE).

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Section: Introductionmentioning

confidence: 99%

Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

2021

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“…Therefore both PAN and ITH are co-formulated together for the treatment of gastric hypersecretory conditions and associated gastrointestinal disorders. Several analytical methods have been developed for the determination of PAN in pharmaceutical preparations such as spectrophotometric methods [3][4][5][6], HPLC methods [7][8][9][10], HPTLC-densitometric methods [11,12] and liquid chromatographic-tandem mass methods (LC-MS/MS) [13,14]. Also several methods have been reported for the determination of ITH in pharmaceutical preparations such as spectrophotometric methods [15][16][17], HPLC methods [18][19][20], HPTLC-densitometric methods [21,22] and spectroflourimetric methods [23].…”

Section: Introductionmentioning

confidence: 99%

Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

Ramadan

El‐Ragehy

Ragab

et al. 2015

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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“…A thorough review of the literature has revealed that several methods have been reported for the determination of pantoprazole alone or in combination in dosage forms and/or plasma. These methods included UV-spectrophotometry [10][11][12][13], HPLC-UV [14][15][16][17][18], LC-MS [19][20][21], capillary electrophoresis [22], thermogravimetric analysis [23], voltammetry [24,25], densitometry [26], and biamperometric analysis [27]. Additionally, various methods have also been developed for the determination of etodolac solely or in combinations in pharmaceutical dosage forms and/or biological fluids.…”

Section: Introductionmentioning

confidence: 99%

A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma

Afifi

2014

Journal of Chemistry

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A simple, sensitive, and accurate HPLC-DAD method has been developed and validated for the simultaneous determination of pantoprazole and etodolac in rat plasma as a tool for therapeutic drug monitoring. Optimal chromatographic separation of the analytes was achieved on a Waters Symmetry C18 column using a mobile phase that consisted of phosphate buffer pH~4.0 as eluent A and acetonitrile as eluent B in a ratio of A : B, 55 : 45 v/v for 6 min, pumped isocratically at a flow rate of 0.8 mL min−1. The eluted analytes were monitored using photodiode array detector set to quantify samples at 254 nm. The method was linear withr2=0.9999for PTZ andr2=0.9995for ETD at a concentration range of 0.1–15 and 5–50 μgmL−1for PTZ and ETD, respectively. The limits of detection were found to be 0.033 and 0.918 μgmL−1for PTZ and ETD, respectively. The method was statistically validated for linearity, accuracy, precision, and selectivity following the International Conference for Harmonization (ICH) guidelines. The reproducibility of the method was reliable with the intra- and interday precision (% RSD) <7.76% for PTZ and <7.58 % for ETD.

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Sensitive liquid chromatography–tandem mass spectrometry method for the determination of pantoprazole sodium in human urine

Cited by 15 publications

References 3 publications

Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

Validated Simultaneous Gradient Ultra-Performance Liquid Chromatographic Quantification of Some Proton Pump Inhibitor Drug Residues in Saudi Pharmaceutical Industrial Wastewater

Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

A Validated HPLC-DAD Method for Simultaneous Determination of Etodolac and Pantoprazole in Rat Plasma

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