Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

Ramadan, Nesrin K.; El‐Ragehy, Nariman A.; Ragab, M. T.; El‐Zeany, Badr A.

doi:10.1016/j.saa.2014.09.003

Cited by 14 publications

(6 citation statements)

References 24 publications

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“…The latter was capable of determining only the component with the less extended spectrum in the mixture [37]. A simple innovative method namely ratio difference was developed capable of determining OXMT in binary mixture with SCG with minimal data processing and high selectivity, regardless which component has more extended spectrum [38][39][40][41]. The utility of ratio difference method is to calculate the unknown concentration of a component of interest present in a mixture containing both component of interest and an unwanted interfering component.…”

Section: Methods C: Ratio Difference Methods (Rd)mentioning

confidence: 99%

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

et al. 2015

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Sodium cromoglycate (SCG) and oxymetazoline hydrochloride (OXMT) are administered in combination for effective treatment of nasal congestion and allergy. In this work, SCG was determined using direct spectrophotometry by measuring its zero order absorption spectra at its λmax 320.6 nm where OXMT showed zero absorbance. On the other hand, four simple, sensitive and precise spectrophotometric methods were developed and validated for the determination of OXMT in the presence of SCG in their laboratory prepared mixtures and pharmaceutical formulation, without preliminary separation; Method A: first derivative spectrophotometric method [ 1 D], Method B: first derivative of ratio spectra method [ 1 DD], Method C: ratio difference spectrophotometric method [RDSM] and Method D: ratio subtraction method [RSM]. Ratio manipulating methods (Method B, C and D) were done using divisor of 10.00 µg/mL SCG. Linear correlation was obtained in range 4-22 µg/mL for OXMT by methods A, B and D and 6-22 µg/mL for method C. All methods were validated in compliance with the International Conference on Harmonization (ICH) guidelines and satisfactory results were obtained. No significant difference was noted between the developed methods and the official one with respect to accuracy and precision.

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Section: Methods C: Ratio Difference Methods (Rd)mentioning

confidence: 99%

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

et al. 2015

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“…Most of the studies have used high performance liquid chromatography (HPLC) for itopride assay in pharmaceutical formulation [3][4][5][6][7][8][9][10][11]. Spectrophotometric methods have also been used for itopride quantitation [12][13][14]. Pure and combined dosage forms have been analyzed using Potentiometric method [15].…”

Section: Introductionmentioning

confidence: 99%

Voltammetric determination of itopride using carbon paste electrode modified with Gd doped TiO2nanotubes

Amro¹,

Emran²,

Alanazi³

2020

Turk J Chem

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In the present work TiO 2 nanotubes (TNT) have been synthesized by alkaline hydrothermal transformation. Then they have been doped with Gd element. Characterizations of doped and undoped TNT have been done with TEM and SEM. The chemical composition was analyzed by EDX, Raman and FTIR spectroscopy. The crystal structure was characterized by XRD. Carbon paste electrode has been fabricated and mixed with Gd doped and undoped TNT to form a nanocomposite working electrode. Comparison of bare carbon paste electrode and Gd doped and undoped TNT carbon paste electrode for 1.0 ×10 −3 M K 4 [Fe(CN) 6 ] voltammetric analysis; it was observed that Gd doped TNT modified electrode has advantage of high sensitivity. Gd doped TNT modified electrode has been used as working electrode for itopride assay in a pharmaceutical formulation. Cyclic voltammetry analysis showed high correlation coefficient of 0.9973 for itopride (0.04-0.2 mg/mL) with a limit of detection (LOD) and limit of quantitation values (LOQ) of 2.9 and 23.0 µg.mL −1 respectively.

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“…The main serum metabolite is formed by demethylation at the 4-position of the pyridine ring, followed by conjugation with sulphate. [1][2][3][4] Several techniques have been developed to estimate PAN in its bulk form, pharmaceutical and biological matrices, including liquid chromatography with different detectors, [5][6][7][8][9][10][11][12] UV-spectrophotometry, [13][14][15] and capillary electrophoresis. 16,17 Electrochemical assays such as voltammetric methods have been widely used for drug analysis due to their sensitivity, simplicity, cheapness and rapidity.…”

Section: Introductionmentioning

confidence: 99%

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

Pınar

2020

ACSi

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The electrochemical oxidation of pantoprazole, a selective proton pump inhibitor, was studied in aqueous as well as aqueous/surfactant media at a disposable pencil graphite electrode using cyclic and adsorptive stripping voltammetric techniques. The sensitivity of the stripping voltammetric measurements was significantly improved when the cationic surfactant, cetyltrimethylammonium bromide (CTAB) was present in the neutral electrolyte solution. For analytical purposes, well resolved voltammetric peaks at +1.05 V (versus Ag/AgCl) were obtained in Britton-Robinson buffer at pH 7.0 containing 3 × 10-4 M CTAB using square-wave stripping mode (after 30 s accumulation at open-circuit condition). The process could be used to determine pantoprazole concentrations in the range of 2.4 × 10-8-7.1 × 10-7 M (9.2-272 μg L-1) with a detection limit of 7.0 × 10-9 M (2.7 μg L-1). The proposed method was applied to the determination of pantoprazole in pharmaceutical formulation and in the spiked human urine samples with acceptable recoveries.

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Simultaneous determination of a binary mixture of pantoprazole sodium and itopride hydrochloride by four spectrophotometric methods

Cited by 14 publications

References 24 publications

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

Spectral resolution and simultaneous determination of oxymetazoline hydrochloride and sodium cromoglycate by derivative and ratio-based spectrophotometric methods

Voltammetric determination of itopride using carbon paste electrode modified with Gd doped TiO2nanotubes

Electrooxidation and Low-tech Determination of Pantoprazole on a Disposable Pencil Graphite Electrode by the use of Cationic Surfactant

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