Sensitive Voltammetric Determination of Niclosamide at a disposable pencil graphite electrode

Dede, Eda; Sağlam, Özlem; Dilgin, Yusuf

doi:10.1016/j.electacta.2014.01.153

Cited by 59 publications

(31 citation statements)

References 31 publications

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“…However, these techniques are limited by the low reproducibility, and there is a clear need to evaluate and propose the use of sensors that are easy to clean and that guarantee the recognized advantages of electroanalysis. Hence, the use of graphite pencil electrodes (GPE) has proven to be a useful and efficient and low cost tool for the determination of drugs in pharmaceutical formulations, without many of the drawbacks found in other methods [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets

Alecrim

Macêdo

Rodrigues

et al. 2019

J. Electrochem. Soc.

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Over the years, Electroanalysis has been widely applied to elucidate redox behavior of novel molecules. The selectivity and low cost are spotlight features in pharmacopeial methods of identification, that can be reached by voltammetric approaches. In this work, differential pulse voltammetric (DPV) profile and the slope of the linear regression obtained from calibration graphs along with the scan study are proposed as new perspective of identification assays. With the proposed methodology we were able to identify the similarities among DPV profile and the slopes obtained for each tablet. In addition, this new technology was successfully employed to identify the following chemicals: Paracetamol (PAR), Promethazine (PMZ), Diclofenac (DIC), Piroxicam (PRX), Indomethacin (IND) and Cyclobenzaprine (CBP) in pharmaceutical assays using Pencil Graphite Electrodes. Furthermore, our new methodology was effectively compared to Raman Spectroscopy for the analysis of the range of chemicals in the pharmaceutical assays.

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Section: Introductionmentioning

confidence: 99%

Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets

Alecrim

Macêdo

Rodrigues

et al. 2019

J. Electrochem. Soc.

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“…Mother milk was used for doublet aims; as it is an alternative to serum to be used without centrifugation nor sedimentation so, save time, equipment and effort, moreover this application helps for earlier detection to prevent side effects in lactating mothers, therefore, we can introduce preliminary study on the pharmacokinetics on all patients specially lactating mothers. Furthermore, PGE and GCE provide the needed advantages as simplicity, cheapness, availability, being solid and environmental friendship over the reported methods for the determination of Mep, PGE provides more advantages to be disposable, cheaper and easier to be used [16][17][18][19][20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Comparative Voltammetric Behavior and Determination of Mephenesin in Pure Form, Pharmaceuticals and Biological Fluids at Pencil Graphite and Glassy Carbon Electrodes

El-Kady¹

2019

SJAC

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New voltammetric methods are introduced for the determination of a skeletal muscle relaxant namely; mephenesin (Mep) in its pure form with the application in the pharmaceutical preparation and biological fluids. Three voltammetric methods namely; cyclic voltammetry (CV), differential pulse voltammetry (DPV) and square wave voltammetry (SWV) using pencil graphite electrode (PGE) and glassy carbon electrode (GCE) were used. Voltammetric behavior of Mep was investigated in Britton Robinson (BR) buffer as electrolyte in pH range 2-10. CV produced one irreversible anodic peak revealing oxidation reaction in pH 6 as maximum pH value at 1.33 and 1.36 V using PGE and GCE, respectively. At PGE, DPV and SWV were investigated and linearity ranges were 18.02-119.07 and 18.02-70.0 µg/mL with correlation coefficient 0.9997 and 0.9995, LOD values were found to be 0.113 and 0.059 µg/mL, respectively. At GCE, linearity ranges were 9.05-44.39 and 4.54-65.78 µg/mL with correlation coefficient 0.9996 and 0.9999, LOD values were 0.553 and 0.865 µg/mL at DPV and SWV, respectively. The proposed methods were applied with good recovery in pharmaceutical preparation, human mother milk and urine. They were validated and revealed accurate and precise results.

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“…The advantage of PGE over the existing GCE is its high electrochemical reactivity, commercial availability, good mechanical rigidity, and low cost; the behavior of many pharmaceuticals on GCE was discussed in many of our previous researches [14][15][16]. Although PGE is relatively new type of carbon electrode, it has been successfully applied to the cathodic and anodic voltammetry by virtue of its high electrochemical reactivity, low technology, and ease of modification [17][18][19][20][21][22]. In the present work we reported the electrochemical behavior of NP⋅HCl using activated glassy carbon (GCE) and pencil graphite electrode (PGE) in Britton-Robinson buffer of pH 6.00 and 7.00 using pencil graphite electrode (PGE) and activated glassy carbon (GCE) electrode, respectively.…”

Section: Introductionmentioning

confidence: 99%

Utility of Activated Glassy Carbon and Pencil Graphite Electrodes for Voltammetric Determination of Nalbuphine Hydrochloride in Pharmaceutical and Biological Fluids

Elqudaby

Hendawy

Souaya

et al. 2016

International Journal of Electrochemistry

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This work compares voltammetric response of nalbuphine hydrochloride (NP⋅HCl) at both activated glassy carbon and pencil graphite electrodes. The electrochemical oxidation of the drug was studied using cyclic voltammetry (CV), differential pulse voltammetry (DPV), and square wave voltammetry (SWV) techniques. For analytical purpose a well-resolved irreversible diffusion controlled voltammetric peak was established in Britton-Robinson (B-R) buffer solution of pH 6.00 using pencil graphite electrode (PGE). Using activated glassy carbon electrode (GCE) a well-resolved irreversible diffusion controlled voltammetric peak was obtained at pH 7.00 using the same buffer solution. According to the linear relationship between the peak current and NP⋅HCl concentration, DPV and SWV methods were developed for their quantitative determination in pharmaceutical and human biological fluids. The linear response was obtained in the range from 1.6×10 −5 to 1.5×10 −4 mol L −1 using PGE and from 12.5×10 −6 to 13.75 × 10 −5 mol L −1 using a GC electrode, respectively. Precision and accuracy of the developed method were checked by recovery studies.

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Sensitive Voltammetric Determination of Niclosamide at a disposable pencil graphite electrode

Cited by 59 publications

References 31 publications

Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets

Raman Spectroscopy vs Voltammetry: A Voltammetric Approach to Elucidate Different Chemicals in a Range of Pharmaceutical Tablets

Comparative Voltammetric Behavior and Determination of Mephenesin in Pure Form, Pharmaceuticals and Biological Fluids at Pencil Graphite and Glassy Carbon Electrodes

Utility of Activated Glassy Carbon and Pencil Graphite Electrodes for Voltammetric Determination of Nalbuphine Hydrochloride in Pharmaceutical and Biological Fluids

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