In view of the multi-source uncertainty disturbance problem during flight control, the attitude autopilot based on fuzzy linear active disturbance rejection control (F-LADRC) was proposed. A second-order linear active disturbance rejection controller was designed to stabilize the attitude angle of the missiles, and the frequency domain characteristics were analyzed. Firstly, it was proved that the linear expansion state observer (LESO) is convergent and can achieve the indifference estimation of the system state variables and total disturbance. Then, it was proved that the linear active disturbance rejection control (LADRC) possesses disturbance rejection characteristics, and the influence of the bandwidth parameter on the disturbance rejection performance of the system was analyzed. The fuzzy control was used to adjust the parameter adaptively. Finally, the tracking, robustness, and anti-disturbance of the F-LADRC attitude autopilot were verified by performing simulations.