Sensitivity analysis of parameters and methodological choices used in calculation of radiation detriment for solid cancer

Zhang, Wei; Laurier, Dominique; Cléro, Énora; Hamada, Nobuyuki; Preston, Dale L.; Vaillant, Ludovic; Ban, Nobuhiko

doi:10.1080/09553002.2020.1708499

Cited by 25 publications

(38 citation statements)

References 19 publications

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“…The minimum quality of life q min and the relative loss of life expectancy L have only a small impact on the amount of damage, whereas the lethality factor has a very strong effect. This is in good agreement with sensitivity analyses by Zhang et al ( 2020 ), who investigated the influence of various parameters on the detriment calculation.…”

Section: Impact Of the Damage Function D ( supporting

confidence: 91%

Do we really need the “detriment” for radiation protection?

Breckow

2020

Radiat Environ Biophys

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The purpose of the ICRP detriment concept is to enable a quantitative comparison of stochastic radiation damage for the various organs. For this purpose, the organ-specific nominal risk coefficients are weighted with a function that is intended to express the amount of damage or, respectively, the severity of a disease. This function incorporates a variety of variables that do not depend on radiation parameters, but on characteristics of the disease itself. The question is raised as to whether the rather subtle way of defining the amount of damage is necessary for radiation protection purposes and whether a much simpler relationship can serve for this purpose as well or even better.

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Section: Impact Of the Damage Function D ( supporting

confidence: 91%

Do we really need the “detriment” for radiation protection?

Breckow

2020

Radiat Environ Biophys

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“…Its estimates are approximately the same for doses smaller than 0.4 Gy, but as the dose increases, the LAR estimates become higher than the REIC/REID ones, reaching +2% at 1 Gy (Zhang et al. 2020 ). Therefore, the presented LAR estimates for doses up to 1 Gy may be within this difference from the REIC estimates, but a higher difference may occur for the 1.5 Gy estimates.…”

Section: Discussionmentioning

confidence: 99%

The risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case

Viani

Weber

Bruno

et al. 2020

International Journal of Radiation Biology

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“…Our risk evaluation by the LAR measure, an approximation to the risk of exposure induced cases (REIC), seems adequate in our study since it allows for a simplified but sufficiently precise approximation of the risk in the dose range of our study. 44 Although we evaluated the risk accounting for statistical uncertainty in the parameter estimates of the risk model, there were many other uncertainties not sufficiently accounted for. The risk model used Abbreviations: FR, fractional ratio of the excess cases to the total cases (baseline + excess); LAR, lifetime attributable risk; LBR, lifetime background risk; N.S., not specified.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the lifetime brain/central nervous system cancer risk associated with childhood head CT scanning in Japan

Kadowaki

Hamada

Kai

et al. 2020

Intl Journal of Cancer

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The use of computed tomography (CT) scanning has increased worldwide over the decades, and Japan is one of the leading countries in annual frequency of diagnostic CT. Although benefits of CT scan are undisputable, concerns have been raised about potential health effects of ionizing radiation exposure from CT, particularly among children who are likely more susceptible to radiation than adults. Our study aims to evaluate the cumulated lifetime risk of the brain/central nervous system (CNS) cancer due to head CT examinations performed on Japanese children at age 0 to 10 years in 2012, 2015 and 2018. The frequency and dose distribution of head CT examinations were estimated based on information from recent national statistics and nationwide surveys. The lifetime risk attributable to exposure was calculated by applying risk models based on the study of Japanese atomic‐bomb survivors. In contrast to the overall increasing trend, the frequency of childhood CT, especially at age < 5, was decreasing, reflecting a growing awareness for efforts to reduce childhood CT exposure over the past decade. In 2018, 138 532 head CT examinations were performed at age 0 to 10, which would consequently induce a lifetime excess of 22 cases (1 per 6300 scans) of brain/CNS cancers, accounting for 5% of the total cases. More excess cases were estimated among men than among women, and excess cases could emerge at relatively young ages. These results would have useful implications as scientific basis for future large‐scale epidemiological studies and also as quantitative evidence to justify the benefits of CT vs risks in Japan.

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Sensitivity analysis of parameters and methodological choices used in calculation of radiation detriment for solid cancer

Cited by 25 publications

References 19 publications

Do we really need the “detriment” for radiation protection?

Do we really need the “detriment” for radiation protection?

The risk of induced cancer and ischemic heart disease following low dose lung irradiation for COVID-19: estimation based on a virtual case

Evaluation of the lifetime brain/central nervous system cancer risk associated with childhood head CT scanning in Japan

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