Sensitivity and Detection Rate of a 12-Core Trans-Perineal Prostate Biopsy: Preliminary Report

Rocco, Bernardo; Cobelli, Ottavio De; Léon, Maria Elena; Ferruti, M.; Mastropasqua, Mauro G.; Matei, Deliu Victor; Gazzano, Giacomo; Verweij, Fabrizio; Scardino, E.; Musi, Gennaro; Djavan, Bob; Rocco, Francesco

doi:10.1016/j.eururo.2005.12.021

Cited by 38 publications

(28 citation statements)

References 30 publications

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“…Unsuspected prostate cancer in radical cystoprosatectomy specimens were shown to generally involve small lesions localized within the prostate [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. The present study also confirmed this finding; that is, incidentally detected prostate cancer was regarded as having more favorable characteristics in terms of serum PSA, pathological stage, Gleason score, perineural invasion and capsular penetration than clinically detected prostate cancer.…”

Section: Discussionsupporting

confidence: 92%

“…In this series, incidental prostate cancers were found in 12.3% of cystoprostatectomy specimens, which was remarkably low compared with those in previous studies from Western countries; that is, when the outcomes of 18 studies summarized in Table 3 were combined, the proportion of incidental prostate cancer in Western countries appeared to be 28.0% [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Considering the well-established finding that the incidence of latent prostate cancer in Japan is similar to that in Western countries [22], these outcomes suggest that different mechanisms are involved in the development of incidental and latent cancers in Japanese and Western men.…”

Section: Discussionmentioning

confidence: 51%

“…These latent cancers are usually small, well or moderately differentiated, and localized within the prostate. In general, the majority of prostate cancers detected in the prostate of cystoprostatectomy specimens from patients undergoing bladder cancer surgery have also been regarded as clinically insignificant disease [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Therefore, analyzing cystoprostatectomy specimens, which offer a unique opportunity to study the incidence and morphological features of incidental prostate cancer, would be an interesting approach to characterize differences between incidentally and clinically detected prostate cancers.…”

Section: Introductionmentioning

confidence: 99%

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Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

et al. 2009

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 51%

Section: Introductionmentioning

confidence: 99%

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Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

et al. 2009

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“…Incidental prostate carcinoma rates detected in cases having undergone RCP due to bladder tumor vary between 4% and 60% (Table 2) (2,6,(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). One of the reasons for these various rates has been linked to the use of section intervals in different widths.…”

Section: Discussionmentioning

confidence: 99%

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

Balci¹,

Onuk²,

Hazar³

et al. 2016

JAREM

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Objective: Prostate cancer (PC) is one of the major health problems among males. Pathology specimens of patients with incidental PC who underwent radical cystoprostatectomy (RCP) have been reported to be 17-70% in different series. In this study, we aimed to determine the frequencies and features of incidental PC in patients who underwent RCP.Methods: In our study, 142 patients who underwent RCP were retrospectively evaluated between 1999 and 2015. Women and patients diagnosed with PC before were excluded. Preoperative PSA levels were 2.05-9.31 ng/mL. Standard RSP and standard pelvic lymphadenectomy were performed.Results: Incidental PC was detected in 22 of 142 patients. The frequency of incidental PC was found to be 15.4% in RSP materials. In 10 of 22 patients with PC, high-grade prostatic intraepithelial neoplasia (PIN) areas were detected. Further, 14 of 120 patients without PC had highgrade PIN zones. In 140 patients, transitional cell carcinoma was detected, and the other 2 patients had signet ring cell carcinoma. In bladder specimens, 68 patients were in the T2 stage, while 58 patients and 16 patients were in the T3 and T4 stages, respectively. The Gleason score (GS) was 2+3=5 in 2 of the 22 incidental PC patients. Moreover, 6 patients had GS of 3+2=5 and 14 patients had GS of 3+3=6. Conclusion:Most incidentally detected PCs in RCP specimens are small, localized, and well-differentiated tumors. Extracapsular extension was not observed in any of them. Patients with invasive bladder tumors and PCs together have a lower T stage than those with only invasive bladder tumors. The risk of PC is higher in patients with invasive bladder cancer than in the healthy population. Preoperative prostate evaluation, prostate dissection, and resection should be performed with oncologic surgery. (JAREM 2016; 6: 15-8)

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“…The Standard systematic 12 core TRUS biopsy has a sensitivity ranging from 45-75% for clinically significant prostate cancer [11,12] [13]. Transperineal Template mapping biopsy (TTMB) has sought to improve on these sensitivities by taking more cores and sampling the anterior and midline prostate which can be difficult to reach via the trans rectal route.…”

Section: Problems With the Existing Diagnostic Pathway That Mri May Pmentioning

confidence: 99%

The role of the multiparametric MRI in the diagnosis of prostate cancer in biopsy-naïve men

Rhudd

McDonald

Emberton

et al. 2017

Current Opinion in Urology

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Purpose of review: To review the role of pre-biopsy multi-parametric MRI in biopsy-naïve men for the detection of clinically significant prostate cancer.Recent findings: Recent Level 1 evidence shows that multi-parametric MRI has high sensitivity and negative predictive value for the detection of clinically significant prostate cancer in biopsy-naïve men. Concurrent developments include important work in the standardization of MRI-reporting. The low specificity and positive predictive value of MRI means that biopsy is still necessary following MRI.MRI-targeted prostate biopsy has emerged as an alternative diagnostic test to transrectal ultrasound guided prostate biopsy, though its exact role in biopsy naïve men and the optimal technique remain to be defined. Summary:There is the potential for MRI to be used as a triage test to allow a proportion of men to avoid biopsy and remain on PSA surveillance. MRI-suspicious areas can be sampled more intensively using MRI-targeted biopsy that can be carried out in a variety of ways. Future work should focus on the cost-effectiveness of introducing a pre-biopsy MRI pathway in biopsy naïve men and addressing the training needs for such a change.

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Sensitivity and Detection Rate of a 12-Core Trans-Perineal Prostate Biopsy: Preliminary Report

Cited by 38 publications

References 30 publications

Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

Characterization of prostate cancer incidentally detected in radical cystoprostatectomy specimens from Japanese men with bladder cancer

Incidental Prostate Cancer Frequency and Features of Patients Undergoing Radical Cystoprostatectomy

The role of the multiparametric MRI in the diagnosis of prostate cancer in biopsy-naïve men

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