Sensitivity and reproducibility of Thayer-Martin culture medium in diagnosing gonorrhea in women

Caldwell, Joe; Price, Eleanor V.; Pazin, George J.; Cornelius, Chalmers E.

doi:10.1016/0002-9378(71)90346-2

Cited by 38 publications

(4 citation statements)

References 5 publications

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“…This can be reduced to 24 h if coagglutination or fluorescent-antibody tests are used for the definitive identification of Neisseria gonorrhoeae (8,14). Regardless of the method used to identify Neisseria isolates by species, the sensitivity of a single endocervical culture for diagnosing gonorrhea in females appears to be less than 90% (2,13,15). Clearly, a rapid, sensitive, and specific technique for detecting N. gonorrhoeae in clinical specimens would greatly assist public health efforts to control the spread of gonorrhea.…”

mentioning

confidence: 99%

Validity of an enzyme immunoassay for detection of Neisseria gonorrhoeae antigens

Papasian¹,

Bartholomew²,

Amsterdam³

1984

J Clin Microbiol

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An enzyme immunoassay (EIA; Gonozyme, Abbott Laboratories) for the antigenic detection of Neisseria gonorrhoeae in endocervical or urethral specimens was evaluated. EIA results were compared with results of conventional culture tests for N. gonorrhoeae. Specimens from 208 males (113 culture positive) and 252 females (72 culture positive) were tested. The sensitivity and specificity of EIA for specimens from males were 97.3 and 95.8%, respectively. The sensitivity and specificity of EIA for specimens from females were 79.2 and 87.2%, respectively. Gonorrhea ranks first among reported communicable diseases in the United States. More than 1,000,000 cases were reported in 1979, and it is estimated that an additional 600,000 to 1,000,000 cases were not reported in that year (3).

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mentioning

confidence: 99%

Validity of an enzyme immunoassay for detection of Neisseria gonorrhoeae antigens

Papasian¹,

Bartholomew²,

Amsterdam³

1984

J Clin Microbiol

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“…An endocervical culture is more sensitive than a culture from either the vagina, urethra, or anal canal, but detects only 86 to 96% of women who are culture positive at any site (1,7,(11)(12)(13). Through the addition of an anal-canal (1,2,6,7,(12)(13)(14) or a second endocervical (6, 7) culture, the diagnostic yield of a single endocervical culture can be increased by 2 to 7.5%; however, the cost of culturing is nearly doubled. As a compromise, the Center for Disease Control currently recommends that women at high risk of having gonorrhea, i.e., sexually transmitted disease clinic patients, receive both endocervical and anal-canal cultures and women at low risk, i.e., family planning clinic patients, receive only an endocervical culture (3).…”

mentioning

confidence: 99%

Combining cervical and anal-canal specimens for gonorrhea on a single culture plate

Judson¹,

Werness²

1980

J Clin Microbiol

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To reduce the cost of detecting gonorrhea, we studied the effect on diagnostic sensitivity of combining two culture specimens on the same plate of modified Thayer-Martin medium, using specimens from 7,787 women seen consecutively in the clinic. There was no significant difference (P greater than 0.05) between one cervical and one anal-canal specimen placed on separate plates (C,A) and these two specimens combined but spaced apart on a single plate (C/A), or between two cervical specimens combined but spaced apart on the same plate (C/C) and C/A. Therefore, C/C, C/A, and C,A have equivalent diagnostic sensitivities. C/A detected 5.68% more women with gonorrhea than did a single cervical culture (C) (P less than 0.001). If C/A were to replace C,A for culture specimens from women seen in venereal disease clinics and C for specimens taken and cultured outside of venereal disease, gonorrhea control programs in the United States could realize savings in excess of $2.5 million per year.

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“…Although early workers did not have the advantages offered by modern culture media, Jesionek cultured the gonococcus from the rectum in 1898 and established the entity of gonococcal proctitis (6). Early investigators stated that infection of the rectum occurred in about 30% of all female gonorrhea (6), a figure that compares favorably with recent surveys (1,7).…”

Section: Discussionmentioning

confidence: 89%

Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

et al. 1972

Antimicrob Agents Chemother

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Sensitivity and reproducibility of Thayer-Martin culture medium in diagnosing gonorrhea in women

Cited by 38 publications

References 5 publications

Validity of an enzyme immunoassay for detection of Neisseria gonorrhoeae antigens

Validity of an enzyme immunoassay for detection of Neisseria gonorrhoeae antigens

Combining cervical and anal-canal specimens for gonorrhea on a single culture plate

Treatment of Gonorrhea with Spectinomycin Hydrochloride: Comparison with Standard Penicillin Schedules

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