Sensitivity and Specificity of Ultrasonography in Detecting Thyroiditis

Tabur, Suzan; Yasar, Ozgur; Koylu, Ahmet O.; Sabuncu, Tevfik

doi:10.1097/01.ten.0000257437.32997.af

Cited by 5 publications

(3 citation statements)

References 12 publications

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“…Furthermore, Tabur et al found that sonography has high specificity (90%) and low sensitivity (35%) in the diagnosis of thyroiditis. [30] Furthermore, in the current study, coarse echotexture as a sign of HT had a sensitivity of 81.54%, a result similar to those of Patel et al , who found that diffuse heterogeneity had a sensitivity of 88.2% in the diagnosis of HT. [31]…”

Section: Discussionsupporting

confidence: 89%

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Hefeda

2019

JCIS

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Background and Aim: This study was performed to evaluate the role and accuracy of shear wave elastography in the differentiation between Graves’ disease (GD) and Hashimoto’s thyroiditis (HT), in comparison with the B-mode ultrasound and color Doppler ultrasound. Materials and Methods: This study was non-randomized prospective study. The study included 30 patients with GD, 65 patients with HT, and 35 patients with normal thyroid glands. Assessment of ultrasonographic criteria, color Doppler flow pattern, and shear patterns differed significantly between the control group and the group of diffuse thyroid disease (P < 0.001). The most specific sign for diagnosing HT was nodularity (97.87%), and the most sensitive sign was coarse echotexture (81.54%). Color Doppler flow (CDF) showed sensitivity of 91.8%, specificity of 56.92%, positive predictive value of 52.54%, negative predictive value of 92.5%, and diagnostic accuracy of 68.69% in the differentiation between GD and HT. The mean shear wave velocity (SWV) was 2.61 ± 0.32 m/s in the GD group (range: 2.1–3.21 m/s), 2.85 ± 0.52 m/s in the HT group (range: 2.31–3.82 m/s), and 1.75 ± 0.37 m/s in the control group (range: 1.24–2.36 m/s). The mean SWVs in the GD and HT groups were significantly higher than that in the control group (P < 0.001). The mean SWV in the HT group was higher than that in the GD group (P = 0.03). Conclusion: Quantitative and qualitative SWE is useful for diagnosing diffuse thyroid disease and evaluating the degree of fibrosis in autoimmune thyroiditis. However, acoustic radiation force impulse techniques cannot differentiate between HT and GD reliably.

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Section: Discussionsupporting

confidence: 89%

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Hefeda

2019

JCIS

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“…Grayscale thyroid sonography has proved to be a useful, inexpensive diagnostic tool for the management of patients with autoimmune thyroid disease, mainly Hashimoto thyroiditis and Graves disease. In such cases, it has 35% to 84% sensitivity and 82% to 96% specificity for detecting and characterizing the disruption of thyroid tissue architecture 1 , 2 . Moreover, it can distinguish subgroups of patients with different clinical courses 3 and disease activity, 4 detect early subclinical thyroid dysfunction, 5 and predict the risk of the evolution of subclinical to overt hypothyroidism 6 , 7 .…”

mentioning

confidence: 99%

Value of the Left Inferior Thyroid Artery Peak Systolic Velocity in Diagnosing Autoimmune Thyroid Disease

Banaka

Thomas

Kaltsas

2013

J of Ultrasound Medicine

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The left inferior thyroid artery PSV was the most accurate sonographic parameter for the diagnosis of autoimmune thyroid disease. Measurement of the inferior thyroid artery PSV could be used in patients with a normal grayscale sonographic appearance and inconclusive clinical and biochemical parameters to substantiate the diagnosis of autoimmune thyroid disease. Further studies are needed to evaluate and expand the use of this index.

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“…Frequency of thyroid gland function decrease was particularly pronounced in the group with significantly decreased echogenicity; even in 76% of patients a disfunction was found in the sense of sublinical or clinical hypothyreoidism. Other authors also found higher frequency of thyroid gland hypoechogenicity in persons with higher TSH values, in relation to the group of per- sons with normal values 3,[9][10][11][12][13] . It is stated that only 2.2% persons with normal ultrasound echogenicity suffer from subclinical hypothyreoidism.…”

Section: Discussionmentioning

confidence: 79%

Decreased ultrasound echogenicity as a thyroid hypofunction marker and correlation with autoantibody levels

et al. 2018

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Background/Aim. The value of ultrasound in functional disorders can be significant. That is why the question arises on the use of ultrasound examination of thyroid gland and its echogenicity as a screening method in early detection of disfunctions, of the gland primarily subclinical and clinical forms of hypothyreoidism. The objective of this paper was to determine antibodies of thyroid peroxidase (anti-TPO) and thyroglobuline antibodies (anti-TG) increase frequency in relation to the character of ultrasound echogenicity as well as to estimate the frequency of subclinically and clinically obvious hypothyreoidism in relation to the changed echogenicity. Methods. Study included 656 patients in outpatient clinic during 2014. All examinees underwent ultrasound examination of thyroid gland, the blood was taken for determination of free thyroxine (FT4), thyroidstimulating hormone (TSH), anti-TPO and anti-TG. The patients were divided into two groups; the group A with normal echogenicity of thyroid gland tissue, and the group B with decreased echogenicity. The group B was divided into two subgroups, B1 with a mildly decreased and B2 with significantly decreased echogenicity. Results. TPO antibody, TSH and TG antibody positivity and their mean values in the group B were significantly higher, as well as in subgroups B1 and B2, in relation to the group A (p < 0.001). In the group A, only 4 (1%) examinees were indicated with subclinical hypothyreoidism. In the group B, the sublinical hypothyreoidism was indicated in 42, while the clinical hypothyreoidism was indicated in 16 examinees. Fifty-eight (25%) examinees suffered from thyroid gland altered function. In the subgroup B1, 16 examinees were indicated with subclinical and 4 with clinical hypothyreoidism. Twenty (11%) examinees suffered from altered thyroid function. In the group B2, the subclinical hypothyreoidism was found in 26 examinees, while the clinical hypothyreoidism was found in 12. Thirty-eight (76%) examinees suffered from altered thyroid function. Conclusion. The ultrasound screening of thyroid gland plays an important role in early detection of thyroid disfunction, i.e., sublinical and clinical hypothyreoidism. Decreased ultrasound echogenicity represents the significant marker of altered thyroid gland function. In these persons we have determined the high percentage of subclinical and clinical hypothyreoidism frequency.

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Sensitivity and Specificity of Ultrasonography in Detecting Thyroiditis

Cited by 5 publications

References 12 publications

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Value of the New Elastography Technique using Acoustic Radiation Force Impulse in Differentiation between Hashimoto’s Thyroiditis and Graves’ Disease

Value of the Left Inferior Thyroid Artery Peak Systolic Velocity in Diagnosing Autoimmune Thyroid Disease

Decreased ultrasound echogenicity as a thyroid hypofunction marker and correlation with autoantibody levels

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