Sensitivity and Specificity of Various Tests for the Diagnosis ofHelicobacter pyloriin Egyptian Children

Frenck, Robert W.; Fathy, Hanan; Sherif, Mohsen; Mohran, Zaynab S.; Mohammedy, Hanan El; Francis, Wagdy; Rockabrand, David M.; Mounir, Bahaa; Rozmajzl, Patrick J.; Frierson, Henry F.

doi:10.1542/peds.2005-2925

Cited by 74 publications

(72 citation statements)

References 32 publications

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“…Low sensitivity among young children with antibody tests has also been reported, and it was believed to result from immaturity of the immune response and to be affected by transfer of maternal IgG antibodies to H. pylori [14] [20]. We found low sensitivity and specificity of UBT and low sensitivity of S-Ab in Group I with 1 to 6 years old patients as previously reported.…”

Section: Discussionsupporting

confidence: 81%

“…Because invasive tests can confirm H. pylori infection directly, they are recommended as more suitable tests for the detection of infection than non-invasive tests. However, feasible accuracy of non-invasive tests for the initial diagnosis has been presented in many reports [14]- [20]. Additionally, false results from invasive tests may occur due to patchy density of H. pylori, active bleeding in the stomach, or the presence of other pathogens producing urease in stomach such as non-Helicobacter pylori Helicobacters [21] [22] [23].…”

Section: Discussionmentioning

confidence: 99%

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A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of Helicobacter pylori Infection in Children

Ikuse¹,

Kudo²,

Obayashi³

et al. 2017

AiM

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Proper diagnosis in the pediatric population is required to eradicate Helicobacter pylori (H. pylori) and prevent gastric cancer. Our aim was to assess the performance of non-invasive tests to diagnose H. pylori infection in pediatric patients. A retrospective analysis was performed on 141 pediatric patients requiring endoscopic evaluation and diagnostic tests for H. pylori infection to define the cause of abdominal symptoms. Non-invasive tests included the 13 C-urea breath test (UBT), a monoclonal stool antigen test using enzymelinked immuno-sorbent assay (mSAT), and a serum immunoglobulin G antibody test using antigens derived from Japanese individuals (S-Ab). This study investigated sensitivity, specificity, likelihood ratios for a positive and a negative test (LR + and LR − ), and accuracy of non-invasive tests, in comparison with invasive tests. Eighty two of 141 patients (58%) were recognized as H. pylori positive by invasive methods. When UBT, mSAT or S-Ab were analyzed, all were found to be effective over 94% accurate. Specificity ranged between 86.7% and 95.8%, and sensitivity ranged between 93.8% and 97.1%. When subjects were stratified into three distinct age groups, the best performance was achieved for 1 -6 years old with mSAT at 100% for sensitivity, specificity, and accuracy. S-Ab yielded the best results for children 7 -12 years old and the UBT test performed best for 13 -18 years old. These results demonstrate the utility of UBT, mSAT, and S-Ab non-invasive tests in diagnosing H. pylori but suggest that certain tests may be optimal for children of distinct ages. Three non-invasive tests, UBT, mSAT and S-Ab showed sufficient sensitivity, specificity and accuracy for the initial diagnosis of H. pylori infection among pediatric patients. Non-invasive tests may contribute to achieving minimum invasive diagnosis with combining with a histological test and a culture test in children.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of Helicobacter pylori Infection in Children

Ikuse¹,

Kudo²,

Obayashi³

et al. 2017

AiM

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“…Similar results were also the outcome of a multicenter Japanese stu dy conducted in 2002, making UBT a reliable test for H. pylori infections [40] . Study from developing world also suggest that UBT is a highly accurate and reliable diagnostic modality as reflected by another study form Egypt that revealed a sensitivity and specificity of UBT to be 98% and 89% respectively [41] .…”

Section: Practical Application Of Carbon Breath Testingmentioning

confidence: 90%

Update on diagnostic value of breath test in gastrointestinal and liver diseases

Siddiqui

Ahmed

Abid

2016

WJGP

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In the field of gastroenterology, breath tests (BTs) are used intermittently as diagnostic tools that allow indirect, non-invasive and relatively less cumbersome evaluation of several disorders by simply quantifying the appearance in exhaled breath of a metabolite of a specific substrate administered. The aim of this review is to have an insight into the principles, methods of analysis and performance parameters of various hydrogen, methane and carbon BTs which are available for diagnosing gastrointestinal disorders such as Helicobacter pylori infection, small intestinal bacterial overgrowth, and carbohydrate malabsorption. Evaluation of gastric emptying is routinely performed by scintigraphy which is however, difficult to perform and not suitable for children and pregnant women, this review has abridged the 13C-octanoic acid test in comparison to scintigraphy and has emphasized on its working protocol and challenges. A new development such as electronic nose test is also highlighted. Moreover we have also explored the limitations and constraints restraining the wide use of these BT. We conclude that breath testing has an enormous potential to be used as a diagnostic modality. In addition it offers distinct advantages over the traditional invasive methods commonly employed.

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“…In developing countries infants have high infection rate (up to 50%) as early as of 2 year old [6] and most of them harbor the organism [7] . H. pylori constitutes a real challenge in Egypt as its prevalence in children is noted to be high ranging from 33 -60% and up to 90 % in adults [8] .…”

Section: Introductionmentioning

confidence: 99%

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

Mohamed¹,

Mina

Tosson

et al. 2016

Journal of Gastroenterology and Hepatology Research

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Sensitivity and Specificity of Various Tests for the Diagnosis ofHelicobacter pyloriin Egyptian Children

Abstract: The urea breath test and HpSTAR stool antigen kit are reliable tests for the noninvasive diagnosis of H. pylori among children living in the Middle East.

Cited by 74 publications

References 32 publications

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i> Infection in Children

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i> Infection in Children

Update on diagnostic value of breath test in gastrointestinal and liver diseases

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

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Sensitivity and Specificity of Various Tests for the Diagnosis ofHelicobacter pyloriin Egyptian Children

Abstract: The urea breath test and HpSTAR stool antigen kit are reliable tests for the noninvasive diagnosis of H. pylori among children living in the Middle East.

Cited by 74 publications

References 32 publications

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection in Children

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of &lt;i&gt;Helicobacter pylori&lt;/i&gt; Infection in Children

Update on diagnostic value of breath test in gastrointestinal and liver diseases

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

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A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i> Infection in Children

A Retrospective Analysis of Three Non-Invasive Tests for Initial Diagnosis of <i>Helicobacter pylori</i> Infection in Children