Sensitivity Improved SPR Biosensor Based on the MoS2/Graphene–Aluminum Hybrid Structure

Wu, Leiming; Jia, Yue; Jiang, Leyong; Guo, Jun; Dai, Xiaoyu; Xiang, Yuanjiang; Fan, Dianyuan

doi:10.1109/jlt.2016.2624982

Cited by 186 publications

(75 citation statements)

References 39 publications

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“…4(a) and 4(b). The SPR angle (δθ SPR = 0.35 °) and SRF (δSRF = 0.36 THz) have been increased due to adding the graphene film which is caused for enhancing the sensitivity of this sensor [11][12][13][14]. The detecting attributor's δθ SPR and δSRF are shifting rightwards because of adding the graphene layer, as given in Table 3, as well as table data depicted in Figs.…”

Section: Numerical Resultsmentioning

confidence: 81%

“…In Fig. 6, it is observed that the normalized electric field can obtain greater absorption of light to have large SPW excitation, Md The addition of 2D material (graphene) over the gold layer can affect the field intensity which causes the sensitivity enhancement by increasing the mobility of electrons [11][12][13][14]. The electric field intensity approaches to its maximum value when the reflectance curve shows the minimum value of reflectivity.…”

Section: Photonic Sensors 76mentioning

confidence: 97%

“…Due to the addition of shDNA sequence (pDNA) on the sensing medium, RI increases because of increasing the concentration of the sensing medium followed by (14), and finally the θ SPR and SPRF curves shift as depicted in Fig 5. The sensing parameters R min , θ SPR , SRF, and T max are changing with different concentrated complementary mrDNAs and wtDNAs (ranging from 1 nm to 100 nm), which , table data have been extracted in Table 4. It is evidently decided that the significant right shift of θ SPR and SPRF curve is a sign of perfectly matched hybridization happening in 916delTT and 6174delT with pDNAs [7,22].…”

Section: Transmittance (T) [Db]mentioning

confidence: 99%

“…It shows many properties, such as high optical transparency, low reluctance, high carrier mobility, and tunability [12,13]. In literature [14], graphene was used to improve sensor performance (sensitivity) as biomolecular recognition elements (BRE). For the excitement and propagation of surface plasmons, graphene can be used that has been proved experimentally and theoretically [9].…”

Section: Introductionmentioning

confidence: 99%

“…Since graphene has prominent characteristics [15][16][17][18], a graphene monolayer is sandwiched between the gold film and sensing dielectric as an effective light absorption medium. We use θ SPR -R min (SPR angle-minimum reflectance), as detecting attributor, which enhances the sensitivity of 1+0.35×£ (where £ is the total of graphene coatings) and also use RFC-T max (resonance frequency characteristics-maximum transmittance) attributor, which enhances the sensitivity of 1+0.36×£ compared with the conventional SPR sensor in [19][20][21][22]. This sensor is put in to recognize perfectly matched hybridization event (between shDNA and mrDNA sequence of BRCA1 gene (named 916delTT) and BRCA2 gene (named 6174delT), respectively as shown in Figs.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection: a Numerical Design-Based Analysis

Hossain¹,

Islam

Abdulrazak

et al. 2019

Photonic Sens

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This paper provides a simple hybrid design and numerical analysis of the graphene-coated fiber-optic surface plasmon resonance (SPR) biosensor for breast cancer gene-1 early onset (BRCA1) and breast cancer gene-2 early onset (BRCA2) genetic breast cancer detection. Two specific mutations named 916delTT and 6174delT in the BRCA1 and BRCA2 are selected for numerical detection of breast cancer. This sensor is based on the technique of the attenuated total reflection (ATR) method to detect deoxyribonucleic acid (DNA) hybridization along with individual point mutations in BRCA1 and BRCA2 genes. We have numerically shown that momentous changes present in the SPR angle (minimum: 135 % more) and surface resonance frequency (SRF) (minimum: 136 % more) for probe DNA with various concentrations of target DNA corresponding to a mutation of the BRCA1 and BRCA2 genes. The variation of the SPR angle and SRF for mismatched DNA strands is quite negligible, whereas that for complementary DNA strands is considerable, which is essential for proper detection of genetic biomarkers (916delTT and 6174delT) for early breast cancer. At last, the effect of electric field distribution in inserting graphene layer is analyzed incorporating the finite difference time domain (FDTD) technique by using Lumerical FDTD solution commercial software. To the best of our knowledge, this is the first demonstration of such a highly efficient biosensor for detecting BRCA1 and BRCA2 breast cancer. Therefore, the proposed biosensor opens a new window toward the detection of breast cancers.

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Section: Numerical Resultsmentioning

confidence: 81%

Section: Photonic Sensors 76mentioning

confidence: 97%

Section: Transmittance (T) [Db]mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection: a Numerical Design-Based Analysis

Hossain¹,

Islam

Abdulrazak

et al. 2019

Photonic Sens

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Computational Modeling for Intelligent Surface Plasmon Resonance Sensor Design and Experimental Schemes for Real‐Time Plasmonic Biosensing: A Review

Das,

Yang,

Yang

et al. 2023

Advcd Theory and Sims

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The spectacular physical phenomenon of surface plasmon resonance (SPR) is the essence of present‐day plasmonic sensors. Meanwhile, the unique properties of the interaction between light and matter have been carved out into the development of modern‐day diagnostic biosensors. Plasmons, in simple terms, are oscillating free electrons in metallic nano‐structures triggered by an incoming electromagnetic (EM) wave. With the advantages of real‐time and label‐free bio‐sensing, plasmonic sensors are being utilized in multiple diverse areas of food technology, the bio‐medical diagnostic sector, and even the chemical industry. Although this review will be brief, readers can gain a comprehensive picture of the essential elements by taking a broader look into the exploration of SPR sensor design via simulated studies and representative experimental plasmonic schemes developed for bio‐sensing. In short, the various SPR sensing schemes that researchers have explored to realize enhanced SPR sensitivity are reviewed and summarized. Different experimental plasmonic sensors are also examined in which new SPR excitation schemes have been adopted. These "unconventional" designs, specifically those involving hybrid localized surface plasmon resonance (LSPR)‐SPR excitation, may inspire those in the plasmonic field.

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Numerical Study of Silicon and Tungsten Diselenide Nanomaterial‐Based Surface Plasmon Resonance Sensor for Refractive Index Sensing

Yadav

Lohia

Singh³

et al. 2023

Physica Status Solidi (a)

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A Kretschmann configuration‐based surface plasmon resonance sensor has been proposed. The sensor is made up of calcium fluoride prism, silver, silicon, and tungsten di selenide nanolayer. The theoretical and numerical study of SPR sensor have been analyzed by angle interrogation method with the help of MATLAB 2017b. The transfer matrix method (TMM) is the foundation for simulation and a monochromatic light of wavelength 633nm is considered as source. In the proposed device structure, each layer has been arranged in vertical format to improve the electrical and optical properties. The refractive index for analyte is considered as 1.330 to 1.335. Silver (Ag) metal is used for generation of surface plasmons. It has good chemical properties like metallic conductivity, chemical stability, band gap, small work function and acts as an adhesive layer between calcium fluoride prism and silicon layer. To improve the molecular contact and absorption, the transition metal dichalcogenide nanofilm tungsten di selenide (WSe2) is applied at the top. The sensitivity of 367.4 deg/RIU, detection accuracy of 0.4169 deg‐1, quality factor of 193.58, and full‐width half maximum of 1.8985 deg. are obtained optimized performance parameter of the proposed device structure.This article is protected by copyright. All rights reserved.

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Sensitivity Improved SPR Biosensor Based on the MoS2/Graphene–Aluminum Hybrid Structure

Cited by 186 publications

References 39 publications

Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection: a Numerical Design-Based Analysis

Graphene-Coated Optical Fiber SPR Biosensor for BRCA1 and BRCA2 Breast Cancer Biomarker Detection: a Numerical Design-Based Analysis

Computational Modeling for Intelligent Surface Plasmon Resonance Sensor Design and Experimental Schemes for Real‐Time Plasmonic Biosensing: A Review

Numerical Study of Silicon and Tungsten Diselenide Nanomaterial‐Based Surface Plasmon Resonance Sensor for Refractive Index Sensing

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