2014
DOI: 10.1117/1.jbo.19.11.117001
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Sensitivity of coded aperture Raman spectroscopy to analytes beneath turbid biological tissue and tissue-simulating phantoms

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Cited by 10 publications
(5 citation statements)
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“…Measurements were taken of snoutto-vent length (SVL), head width (HW), body mass and tail length for all tadpoles; liver weights were also taken for tadpoles collected from CT and WH in 2013. After fixation, the following organs were excised: liver, kidney, heart, muscle, and skin, and slices (~0.5 mm thick) taken using a Stadie-Riggs tissue slicer; a technique previously employed for preparing tissue samples for spectroscopy studies (Maher et al, 2014;Obinaju et al, 2014;Taylor et al, 2011). Slices of each organ were mounted onto Low-E reflective glass slides (Kevley Technologies, Chesterland, OH, USA), dried overnight and stored in a desiccator before subsequent interrogation with ATR-FTIR spectroscopy.…”
Section: Tadpole Collectionmentioning
confidence: 99%
“…Measurements were taken of snoutto-vent length (SVL), head width (HW), body mass and tail length for all tadpoles; liver weights were also taken for tadpoles collected from CT and WH in 2013. After fixation, the following organs were excised: liver, kidney, heart, muscle, and skin, and slices (~0.5 mm thick) taken using a Stadie-Riggs tissue slicer; a technique previously employed for preparing tissue samples for spectroscopy studies (Maher et al, 2014;Obinaju et al, 2014;Taylor et al, 2011). Slices of each organ were mounted onto Low-E reflective glass slides (Kevley Technologies, Chesterland, OH, USA), dried overnight and stored in a desiccator before subsequent interrogation with ATR-FTIR spectroscopy.…”
Section: Tadpole Collectionmentioning
confidence: 99%
“…For ATR-FTIR spectroscopy measurements, a longitudinal slice (~0.5 mm thick) was taken from the ventral side of the tadpole using a Stadie-Riggs tissue slicer; a simple technique previously employed for preparing tissue samples for analysis with IR spectroscopy 31 63 64 . Slices were mounted skin side down onto Low-E slides, dried overnight and stored in a desiccator before interrogation with ATR-FTIR spectroscopy.…”
Section: Methodsmentioning
confidence: 99%
“…When measuring bone, confocal RS is primarily sensitive to the cortex, as the transport length of near‐infrared light in bone is only about 500 microns . Diffuse Raman measurements, such as those acquired with coded aperture spectrometers , can sense significantly deeper within the tissue, but provide much coarser resolution that may preclude the separation of signals from different bone layers. Spatially offset Raman spectroscopy (SORS) is another approach that was specifically developed to measure turbid, layered media .…”
Section: Introductionmentioning
confidence: 99%