Sensitivity of Cytokine and Cytokine Mediator Detection aiding in Diagnosis of Premature Coronary Artery Disease Patients

Abstract

, leading to dysfunctional coronary endothelium [4]. Samnegard et al. [5] demonstrated that the systemic concentrations of IL-18 and TNF alpha were higher in post myocardial patients as compared to the controls. Moreover, individuals with elevated levels of TNF alpha were at increased risk for acute myocardial infarction and CAD [6]. High sensitive C-reactive protein (hS CRP) is an established proinflammatory biomarker for the detection of individuals at a risk

The Role of MicroRNAs in Regulating Cytokines and Growth Factors in Coronary Artery Disease: The Ins and Outs

“…The ratio of IL-18/IL-10, as well as levels of C-reactive protein (CRP), a cytokine mediator, is considered diagnostic tools for premature CAD with high sensitivity and specificity. An elevated CRP represents more severe CAD [21].…”